A5009810651- Parkinson's Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Dysphagia Assessment and Management
- Urinary Bladder and Prostate Research
- Healthcare innovation and challenges
- Mental Health and Patient Involvement
- COVID-19 and healthcare impacts
- Pelvic floor disorders treatments
- Healthcare professionals’ stress and burnout
- COVID-19 Clinical Research Studies
- Nutrition and Health in Aging
- Child Nutrition and Feeding Issues
- Stress and Burnout Research
- Long-Term Effects of COVID-19
- Migraine and Headache Studies
- COVID-19 and Mental Health
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Amyotrophic Lateral Sclerosis Research
- Healthcare Operations and Scheduling Optimization
- Cardiovascular Disease and Adiposity
- Blood groups and transfusion
- Obesity, Physical Activity, Diet
- Dietetics, Nutrition, and Education
University of Bristol
2020-2025
Royal United Hospital Bath NHS Trust
2021-2025
Royal United Hospital
2022-2024
North Bristol NHS Trust
2022
Institute of Population and Public Health
2022
Rowan University
2021
At Bristol
2019
Providing informal care for a person with Parkinson's disease (PD) can be demanding process affecting several dimensions of caregiver's life and potentially causing caregiver burden. Despite the emerging literature on burden in people PD, little is known about inter-relationship between quantitative qualitative findings. Filling this knowledge gap will provide more holistic approach to develop design innovations aiming at reducing or even preventing This study aimed characterize determinants...
Parkinson's disease is the second most common neurodegenerative condition after Alzheimer's disease. The number of patients will rise dramatically due to ageing population and possibly also environmental issues. It widely recognised that current models care for people with or a form atypical parkinsonism lack continuity, are reactive problems rather than proactive, do not adequately support individuals self-manage. Integrated have been developed other chronic conditions, range positive...
People living with Parkinson's disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life can lead to an increased risk hospitalisation. It is increasingly recognised that the current care models are not suitable for needs people parkinsonism whose evolve change as progresses. This trial aims evaluate whether a complex innovative model integrated will increase individual's ability achieve their personal goals, have positive health...
Abstract Background In Parkinson’s disease (PD), the propensity to fall and higher risk of osteoporosis converge yielding a high fracture risk. Updated National Osteoporosis Guideline Group (NOGG) guidance recommends that PD should trigger assessment, for example using FRAX tool, yet clinical pathways remain sub-optimal. To address this, we generated an algorithm assessment management bone health specifically in PD. Methods Within Proactive Integrated Management Empowerment Disease...
Abstract Background Culminating evidence shows that current care does not optimally meet the needs of persons with parkinsonism, their carers and healthcare professionals. Recently, a new model was developed to address limitations usual care: Proactive Integrated Management Empowerment in Parkinson’s Disease (PRIME Parkinson). From 2021 onwards, PRIME Parkinson will replace well-defined region The Netherlands. utility be evaluated on single primary endpoint (parkinsonism-related...
Introduction The PRIME-UK randomised controlled trial (RCT) aims to establish whether a model of care that seeks be proactive, integrated and empower participants, caregivers healthcare professionals can improve outcomes in people with parkinsonism. Given this intervention is novel complex, understanding how the will acceptable, implementable, cost-effective scalable across contexts are key questions beyond ‘it works’. We describe an embedded process evaluation answer these questions, which...
Abstract Introduction This paper provides a critical reflection from both the researcher and public contributor (PC) perspective on benefits learnings taken involving PCs in research related to Parkinson's. Approach Patient Public Involvement (PPI) reports how shaped design development of PRIME‐UK programme study materials through input into information leaflets, consent forms other patient‐facing documents used across three studies within programme. The is designed improve quality life...
People with parkinsonism who are older, living in a care home, frailty, multimorbidity or impaired capacity to consent under-represented research, limiting its generalisability. We aimed evaluate more inclusive recruitment strategies.
People with parkinsonism are a highly heterogeneous group and the disease encompasses spectrum of motor non-motor symptoms which variably emerge manifest across course, fluctuate over time negatively impact quality life. While is not directly result ageing, it condition that mostly affects older people, who may also be living frailty multimorbidity. This study aims to describe broad range health needs for people their carers in relation symptomatology, disability, stage, comorbidities...
<h3>Abstract</h3> Hospital medicine in the UK is under unprecedented pressure, with increasing demand on physicians as well challenges recruiting new doctors into physicianly specialties. We sought to assess prevalence of afternoon ward round and its effect those undertaking them. sampled each hospital within our postgraduate region, surveying junior working inpatient medical wards. surveyed roughly two-thirds eligible doctors, finding that 30% juniors had some commitment, varying...
Abstract Background Bladder symptoms are common in Parkinson’s disease (PD), affecting half of all individuals. These have significant impact on quality life as well implications for morbidity, contributing to falls and hospital admission. The treatment bladder can be complicated by the tendency side-effects people with PD including cognitive impairment gait instability anti-muscarinics. development new, better treatments is therefore warranted. Tibial nerve stimulation a form...
Abstract Background Patients with parkinsonism are more likely than age‐matched controls to be admitted hospital. It may possible reduce the cost and negative impact by identifying patients at highest risk intervening hospital‐related costs. Predictive models have been developed in nonparkinsonism populations. Objectives The aims were (1) describe reasons for admission, (2) rates of hospital admission/emergency department attendance over time, (3) use routine data stratify unplanned people...
Abstract Background In Parkinson’s disease (PD) the propensity to fall and higher risk of osteoporosis converge yielding a high fracture risk. Updated National Osteoporosis Guideline Group (NOGG) guidance recommends that PD should trigger assessment, for example using FRAX tool, yet clinical pathways remain sub-optimal. To address this, we generated an algorithm assessment management bone-health specifically in PD. Methods Within Proactive Integrated Management Empowerment Disease randomised...
In the absence of disease-modifying therapies for Parkinson's disease, much research focuses on improving quality life, health and wellbeing. It is important to evaluate potential treatments innovative care models in a robust standardised way. Disease-specific outcomes have limitations older people, those with cognitive impairment, multimorbidity, disability or short life expectancy. We aimed select, adapt as needed, primary outcome multicomponent intervention people parkinsonism.
Introduction The PRIME-UK randomised controlled trial (RCT) aims to establish whether a model of care that seeks be proactive, integrated and empower participants, caregivers healthcare professionals can improve outcomes in people with parkinsonism. Given this intervention is novel complex, understanding how the will acceptable, implementable, cost effective scalable across contexts are key questions beyond ″ it works ″. We describe an embedded process evaluation answer these questions,...
Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare, life-threatening disease, characterised by episodes of microangiopathic haemolytic anaemia (MAHA), thrombocytopenia and small vessel thrombosis. We describe case cTTP first diagnosed at age 70 years in female presenting with an acute ischaemic stroke thrombocytopenia, whom A Disintegrin And Metalloproteinase Thrombospondin type 1 Motif, member 13 (ADAMTS13) levels were <10%, suggestive thrombocytopaenic (TTP). The patient...