A5034100239- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Neurological disorders and treatments
- HIV/AIDS drug development and treatment
- Parkinson's Disease Mechanisms and Treatments
- Nutrition and Health in Aging
- HIV-related health complications and treatments
- Health disparities and outcomes
- Frailty in Older Adults
- Autism Spectrum Disorder Research
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Pharmacy and Medical Practices
- Immunodeficiency and Autoimmune Disorders
- Cerebral Venous Sinus Thrombosis
- Histone Deacetylase Inhibitors Research
- Pharmaceutical Practices and Patient Outcomes
- Neonatal Respiratory Health Research
- Hormonal Regulation and Hypertension
- Acute Ischemic Stroke Management
Radboud University Medical Center
2020-2023
Radboud University Nijmegen
2020-2023
Amsterdam University Medical Centers
2018-2023
University of Amsterdam
2013-2021
Metropolitan University
2015
Amsterdam UMC Location University of Amsterdam
2013-2015
Abstract Numerous clinical trials of anti‐amyloid beta (Aβ) immunotherapy in Alzheimer's disease have been performed. None these provided convincing evidence for beneficial effects. Using traditional frequentist meta‐analysis, the conclusion is that there absence a therapeutic effect, with point estimate effect size 0.05 (95% confidence interval −0.00 to 0.10, P = .055). In addition, this non‐significant equates 0.4 points per year on cognitive subscale Disease Assessment Scale. This well...
Summary Despite advances in our understanding of the mechanisms underlying progression chronic kidney disease and development fibrosis, only limited efficacious therapies exist. The calcium binding protein S100A8/A9 is a damage-associated molecular pattern which can activate Toll-like receptor (TLR)-4 or for advanced glycation end-products (RAGE). Activation these receptors involved renal fibrosis; however, role herein remains unknown. Therefore, we analysed expression patients mice with...
Low values of blood pressure, body mass index (BMI), and non-high-density lipoprotein (HDL) cholesterol have all been associated with increased dementia risk in late life, but whether these factors an additive effect is unknown. This study assessed a combination late-life low for systolic pressure (SBP), BMI, non-HDL higher than individual factors.This post hoc analysis based on observational extended follow-up the Prevention Dementia by Intensive Vascular Care (preDIVA) trial, including...
Introduction Literature on prevalence of symptomatic internal carotid artery stenosis is scarce and heterogeneous. Prevalence may have decreased in recent years due to improved management cardiovascular risk factors. We aim estimate current identify factors ipsilateral patients with hemispheric transient ischaemic attack or stroke the Netherlands. Patients methods included consecutive adult admitted two large hospitals Netherlands 2014 who suffered from amaurosis fugax, retinal ischaemia,...
Serum HIV-1 RNA and p24 antigen levels were examined in 28 seropositive asymptomatic individuals participating a trial on the efficacy of zidovudine. Sixteen remained until 4 years after onset trial, whereas 12 diagnosed with an AIDS-defining event. The serum load determined before therapy during first 8 weeks to establish whether patterns change predictive clinical outcome. Among participants 43% had measurable pretreatment concentrations antigen. Initiation zidovudine was followed by...
Importance High visit-to-visit blood pressure variability (BPV) in late life may reflect increased dementia risk better than mean systolic (SBP). Evidence from midlife to could be crucial understanding this association. Objective To determine whether BPV at different ages was differentially associated with lifetime incident community-dwelling individuals. Design, Setting, and Participants This cohort study analyzed data the Adult Changes Thought (ACT) study, an ongoing population-based...
Currently available treatment options for Parkinson's disease are symptomatic and do not alter the course of disease. Recent studies have raised possibility that cardiovascular risk management may slow progression disease.We estimated effect baseline factors on disease, using measures PD-specific motor signs cognitive functions.We used data from 424 de novo patients 199 age-matched controls observational, multicenter Progression Markers Initiative (PPMI) study, which included follow-up up to...
Abstract Background High visit‐to‐visit blood pressure variability (BPV) is associated with an increased risk of cardiovascular disease. However, for incident dementia, conflicting results are reported. Our objective was to assess the association very long‐term BPV and all‐cause dementia in community‐dwelling individuals. Method Community‐dwelling individuals aged 65 years or older free from were randomly sampled 1994 onwards Kaiser Permanente Washington (KPW), Seattle, USA, included Adult...
Jurhaans, S.; Weverling, G. J.; Goudsmit, Boogaard, Brok, M.; van Strijp, D.; Koot, Gemen, B. Author Information