A5086578757- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Pregnancy and preeclampsia studies
- Cardiovascular and Diving-Related Complications
- Birth, Development, and Health
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Coronary Artery Anomalies
- Vestibular and auditory disorders
- Cardiovascular Health and Disease Prevention
- Delphi Technique in Research
- Neurological Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Infective Endocarditis Diagnosis and Management
- Workplace Health and Well-being
- Cardiovascular Syncope and Autonomic Disorders
- EEG and Brain-Computer Interfaces
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Diseases and Tuberculosis
Radboud University Nijmegen
2015-2025
Radboud University Medical Center
2017-2025
University Medical Center
2024
Medisch Spectrum Twente
2022
University Medical Center Utrecht
2015
Background: Identification of risk factors and causes stroke is key to optimize treatment prevent recurrence. Up one-third young patients with have a cryptogenic according current classification systems (Trial ORG 10172 in Acute Stroke Treatment [TOAST] atherosclerosis, small vessel disease, cardiac pathology, other causes, dissection [ASCOD]). The aim was identify leads for (new) ischemic adults, using the pediatric system from IPSS study (International Pediatric Study). Methods: This...
Importance Cause of ischemic stroke in young people is highly variable; however, the risk recurrence often presented with all subtypes grouped together classification systems such as Trial ORG (danaparoid sodium [Orgaran]) 10172 Acute Stroke Treatment (TOAST) criteria, which limits ability to individually inform patients about their recurrence. Objective To determine short-term and long-term recurrent vascular events after at a age by cause identify factors associated Design, Setting,...
Limited data exist on cognitive performance and return to work after ischemic stroke, especially in patients under 50 years. We investigated whether the subacute phase stroke young adults was associated with unemployment inability retain their jobs among those who returned work. conducted a multicenter prospective cohort study between 2013 2021, enrolling aged 18-49 years first-ever stroke. Cognitive assessments were performed within 6 months following index event, covering seven domains....
Cerebral small vessel disease (SVD) is a common in older adults and major contributor to vascular cognitive impairment dementia. White matter network damage potentially important mechanism by which SVD causes impairment. Earlier studies showed that higher degree of white damage, indicated lower global efficiency (a graph-theory measure assessing information transfer), was associated with scores on performance independent MRI markers for SVD. However, it unknown whether this index the...
Cognitive impairment is a well-known result of stroke, but for cerebellar stroke in young patients detailed knowledge on the nature and extent cognitive deficits limited. This study examined prevalence course large cohort with stroke.
Causes of stroke in young adults differ from those the elderly individuals, and a larger percentage, no cause can be determined. To gain more insight into etiology (cryptogenic) population, we investigated whether trigger factors, such as short-lasting exposure to toxins or infection, may play role.Patients aged 18-49 years with first-ever ischemic intracerebral hemorrhage (ICH) 17 participating centers Netherlands completed questionnaire about 9 potential factors hazard periods on regular...
Background Limited data exists on cognitive recovery in young stroke patients. We aimed to investigate the longitudinal course of performance during first year after at age and identify predictors for recovery. Methods conducted a multicentre prospective cohort study between 2013 2021, enrolling patients aged 18–49 years with first-ever ischaemic stroke. Cognitive assessments were performed within 6 months 1 following index event, covering seven domains. Composite Z-scores using normative...
Introduction: We aimed to investigate the prevalence of cognitive impairment in subacute phase after transient ischemic attack (TIA) and stroke (IS), factors associated with a vascular disorder, subjective complaints their relation objective performance. Patients methods: In this multicenter prospective cohort study, we recruited patients first-ever TIA IS, aged 18–49 years, between 2013 2021 for assessment up 6 months index event. calculated composite Z-scores seven domains. defined as...
Patent foramen ovale (PFO) is a congenital anatomical variant which associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, PFO present from birth. However, it completely unknown how an structure that already at birth large proportion of the population can convert into causes stroke few. Recent studies reported significant association between certain trigger ischemic This study aims investigate these triggers PFO-associated stroke.
Introduction Post-stroke fatigue is frequently present in young adults, but its underlying mechanism still unclear. The aim of the study was to investigate association between lesion location, network efficiency and chronic post-stroke based on voxel-based lesion-symptom mapping structural connectivity analysis. Patients Methods One hundred thirty five patients, aged 18–50 years, with a first-ever transient ischemic attack or cerebral infarction from Follow-Up Transient stroke patients...
Approximately 1 in 10 young stroke patients (18-50 years) will develop post-stroke epilepsy, which is associated with cognitive impairment. While previous studies have shown altered brain connectivity little however known about the changes functional epilepsy and their relationship Therefore, we aimed to investigate whether ischaemic networks this alteration related We included 164 participants a first-ever cerebral infarction at age years), along 77 age- sex-matched controls, from Follow-Up...
This study aims at facilitating counselling by providing clinical data about the outcome of isolated severe IUGR before 24 weeks gestational age. Retrospective cohort in two tertiary referral centers Netherlands from 2008–2014. Inclusion: fetal growth restriction (abdominal circumference and/or estimated weight < p3) without structural anomalies diagnosed between 18–23 We included 218 cases weeks. Mean maternal age was 31 years and 92/218 (42%) nulligravid. Perinatal is presented figure 1....
This study aims at describing the frequency of pre-eclampsia and HELLP syndrome in women diagnosed with isolated severe fetal growth restriction before viability. Retrospective descriptive cohort two tertiary referral centers for prenatal diagnosis Netherlands. Inclusion: singleton pregnancies (fetal abdominal circumference and/or estimated weight < 3rd percentile) between 2008–2014, without structural anomalies. We included 218/225 (97%) consecutive pregnancies, that were complicated by...