A5017565900- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- Cardiomyopathy and Myosin Studies
- Nuclear Structure and Function
- Acute Ischemic Stroke Management
- Muscle Physiology and Disorders
- Cardiovascular Health and Disease Prevention
- Cellular transport and secretion
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- RNA Research and Splicing
- Hearing, Cochlea, Tinnitus, Genetics
- Traumatic Brain Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience of respiration and sleep
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Eye Disorders
Radboud University Nijmegen
2020-2025
Radboud University Medical Center
2020-2025
University Medical Center
2021-2024
University of Duisburg-Essen
2022
Guy's and St Thomas' NHS Foundation Trust
2021-2022
St Thomas' Hospital
2021-2022
King's College London
2021-2022
National Institute of Neurological Disorders and Stroke
2021
Amsterdam Neuroscience
2021
Essen University Hospital
2021
Background: High visit-to-visit blood pressure variability (BPV) has been associated with cognitive decline and cerebral small vessel disease (cSVD), in particular cerebrovascular lesions. Whether day-to-day BPV also relates to cSVD not investigated. Objective: To investigate the cross-sectional association between total MRI burden older memory clinic patients. Methods: We included outpatients referred our clinic, who underwent as part of their diagnostic assessment. determined validated...
Cognitive impairment is a well-known result of stroke, but for cerebellar stroke in young patients detailed knowledge on the nature and extent cognitive deficits limited. This study examined prevalence course large cohort with stroke.
To characterize the spectrum of clinical features in a cohort X-linked myotubular myopathy (XL-MTM) carriers, including prevalence, genetic features, symptoms, and signs, as well associated disease burden.We performed cross-sectional online questionnaire study among XL-MTM carriers. Participants were recruited from patient associations, medical centers, registries United Kingdom, Germany, Netherlands. We used custom-made questionnaire, Checklist Individual Strength (CIS), Frenchay Activities...
Centronuclear myopathy (CNM) is a genetically heterogeneous congenital characterized by muscle weakness, atrophy, and variable degrees of cardiorespiratory involvement. The clinical severity largely explained genotype (DNM2, MTM1, RYR1, BIN1, TTN, other rarer genetic backgrounds), specific mutation(s), age the patient. histopathological hallmark CNM presence internal centralized nuclei on biopsy. Information phenotypical spectrum, subtype prevalence, phenotype-genotype correlations limited....
X-linked myotubular myopathy (XL-MTM) is an early-onset congenital characterized by mild to severe muscle weakness in male individuals. The objective was characterize the clinical spectrum of neuromuscular features carriers.We performed a nationwide cross-sectional study focusing on unselected cohort Dutch XL-MTM carriers. Participants were recruited from centers Netherlands and through European patient associations. Genetic results collected. Carriers classified based ambulatory status...
Abstract Cognitive and affective sequelae of cerebellar disease are receiving increased attention, but their actual rate occurrence remains unclear. Complaints may have a significant impact on patients, affecting social behavior psychological well-being. This study aims to explore the extent subjective cognitive symptoms in patients with degenerative ataxias Netherlands. An explorative was set up heterogeneous group ataxia patients. Self-reported cognition evaluated terms executive...
Abstract Background The cerebellar cognitive affective syndrome (CCAS) encompasses and symptoms in patients with disorders, for which no proven treatment is available. Objectives Our primary objective was to study the effect of anodal transcranial direct current stimulation (tDCS) on performance CCAS patients. Secondary effects ataxia severity, mood, quality life were explored. Methods We performed a randomized, double‐blind, sham‐controlled trial. Thirty‐five included received 10 sessions...
Objective: High visit-to-visit blood pressure variability (BPV) has been associated with cognitive decline and cerebral small vessel disease (cSVD), in particular cerebrovascular lesions. It is likely that the causes consequences of high BPV depend on which temporal resolution investigated. Day-to-day related to function, but not investigated relation cSVD. Therefore, we aimed investigate cross-sectional association between day-to-day total cSVD MRI burden, older memory clinic patients....