A5064450704- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Virus-based gene therapy research
- Oral and Maxillofacial Pathology
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Microbial infections and disease research
- T-cell and Retrovirus Studies
- Veterinary Orthopedics and Neurology
- Radiation Therapy and Dosimetry
- Safe Handling of Antineoplastic Drugs
- Cardiac pacing and defibrillation studies
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Cardiovascular Effects of Exercise
- Viral Infections and Vectors
- Autoimmune Bullous Skin Diseases
- Tumors and Oncological Cases
- Neurogenesis and neuroplasticity mechanisms
- Vector-borne infectious diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Neurological diseases and metabolism
- Vector-Borne Animal Diseases
- Complement system in diseases
VetAgro Sup
2015-2024
Université Claude Bernard Lyon 1
2012-2024
École Nationale Vétérinaire de Toulouse
2001-2020
University of the Americas
2017
École Normale Supérieure - PSL
2003-2010
Médecins du Monde
2006
Instituto de Cardiología y Cirugía Cardiovascular
2003
This study reports cytomorphological, histomorphological, and immunological characterization of 608 biopsy cases canine malignant lymphoma, with epidemiological clinical data, collected from 7 French veterinary pathology laboratories. It compares morphological characteristics lymphoma in canines, per the updated Kiel classification system, those reported humans, World Health Organization (WHO) system. Of tumors described, 24.5% 75.5% were classified as low- high-grade lymphomas,...
The aim of this study is to report 46 new cases canine T-cell lymphomas among a series 140 studied by immunophenotyping (incidence 32.8%). According the updated Kiel classification adapted species, 13 were classified as low-grade and 33 high-grade lymphomas. Among lymphomas, five small clear-cell three pleomorphic small-cell mycosis fungoides. cases, there 11 mixed-, small-, large-cell 6 lymphoblastic 5 unclassifiable plasmacytoid cytohistologic features highly suggestive phenotype on basis...
Background: The etiology of non‐Hodgkin's lymphomas (NHL) is multifactorial. Environmental and genetic factors are frequently incriminated both in humans dogs. Objectives: Our purpose was to study the geographic distribution canine NHL (CNHL) France evaluate environmental influences. Animals: Six hundred eight cases CNHL, diagnosed throughout over 1 year, were collected from 7 Veterinary Histopathologic Laboratories. Methods: Retrospective study. Breeds affected by compared with national...
Canine breeds may be considered good animal models for the study of genetic predisposition to cancer, as they represent clusters. From epidemiologic and case collection studies it emerges that some are more likely develop lymphoma or specific subtypes but available data variable geographically inconsistent. This was born in context European Lymphoma Network with aim investigating breed prevalence canine different countries possible risk overall and/or subtypes. A total 1529 nodal cases...
Squamous cell carcinoma represents 47.4% of all malignant canine digital lesions, but despite its frequency, there are few published studies available. Pathology submission records 154 cases and follow-up 49 animals were analyzed. On the cases, histological evaluation was performed differentiation degree, mitotic index, presence emboli, immunohistochemical expression vimentin E-cadherin. The mean (SD) age affected 10.2 (2.3) years; no sex predisposition recorded. Beauceron Briard 2 new...
Objectives The aim of the study was to describe clinical outcome 30 cats with non-ocular melanomas and evaluate association between or pathological parameters overall survival time. Methods database animal histopathological laboratory National Veterinary School Nantes (Oniris, Nantes, France) retrospectively searched identify cases feline December 2009 April 2014. For each case, data, including signalment, location primary tumour, staging, treatment outcome, were collected from medical...
The aim of this study is to determine the clinical, morphological, and immunophenotypical presentation 9 cases a particular type canine T-cell lymphoma/leukemia. morphological was diffuse infiltration small, medium-sized, or large blast cells with eccentric nuclei, hyperbasophilic cytoplasm, juxtanuclear, pale cytoplasmic area, giving plasmacytoid appearance suggesting B-cell morphology. Surprisingly, all were phenotype (CD3 + ). Among 7 immunophenotyped cases, 4 CD4 – /CD8 , 2 CD8 /CD4 1 ....
Abstract Specific data regarding outcome of cats with high‐grade and large granular lymphocyte alimentary lymphoma (HGAL LGL, respectively) treated multi‐agent chemotherapy are scarce. The aims this multi‐centric, retrospective study were to describe the HGAL LGL COP‐ or CHOP‐based identify potential prognostic factors. Cats a cytological histological diagnosis protocol as first‐line included. Data diagnosis, staging, treatment follow‐up collected. Fifty‐seven CHOP ( n = 37) COP 20)...
Abstract Background Myeloma‐related disorders (MRDs) are rare and poorly documented neoplasms of cats. Hypothesis/Objectives To describe clinical, clinicopathologic, imaging findings, response to treatment, survival time identify factors associated with shorter outcomes in cats MRD. Animals Fifty a diagnosis Methods Cats paraproteinemia confirmed by serum protein electrophoresis (SPE) either intramedullary plasmacytosis >10%, marked cytonuclear atypia that ranged between 5% 10%, or...
Dogs with lymphoma are established as good model for human non-Hodgkin studies. Canine cell lines derived from lymphomas may be valuable tools testing new therapeutic drugs. In this context, we a canine T-cell line, PER-VAS, primary aggressive large granular morphology. Flow cytometric analysis revealed stable immunophenotype: PER-VAS cells were positively labelled CD5, CD45, MHC II and TLR3, negative CD3, CD4 CD8 expression. Although unstable along the culture process, IL-17 MMP12 proteins...
A case of presumed primary muscular lymphoma in an 8-year-old, intact, male Newfoundland dog is reported. The was presented for evaluation infiltrating ventral cervical mass, respiratory distress, and anorexia 1-month duration. Fine-needle aspiration the mass revealed anaplastic large cell lymphoma. Despite chemotherapy, health status declined animal euthanized a few weeks later. At necropsy, infiltrated muscles extended ventrally to left forelimb cranially tongue laryngeal musculature....
Glioblastoma is the most aggressive primary brain tumor leading to death in of patients. It comprises almost 50–55% all gliomas with an incidence rate 2–3 per 100,000. Despite its rarity, overall mortality glioblastoma comparable frequent tumors. The current standard treatment combines surgical resection, radiotherapy and chemotherapy temozolomide. In spite this multimodality protocol, prognosis poor median survival remains about 12–14.5 months. regard, new therapeutic approaches should be...
Previous studies in humans with breast, colorectal or liver cancer showed that neoplasia was associated a modification of the blood ratio between 65 Cu and 63 (∂Cu). The aim present study to compare ∂Cu dogs healthy controls non-oncologic disease. One hundred seventeen were included (35 cancer, 33 non-neoplastic disease, 49 controls). significantly lower than (P < 0.0001) but not different from Six lymphoma also evaluated after they achieved clinical remission five out six had an increase...
To prospectively describe the clinical and biological impact of vector-borne haemopathogens in anaemic dogs France occurrence haemolysis.This prospective descriptive cohort study includes 134 client-owned that were on admission at Veterinary Teaching Hospital VetAgro Sup, Lyon, France. They underwent comprehensive screening with PCR to detect a panel haemopathogens, SNAP Leishmania 4Dx Plus (IDEXX).Vector-borne haemopathogen-associated anaemia accounted for 17·2% (23/134) cases. Babesia...