A5057369372- Veterinary Equine Medical Research
- Advanced Chemical Sensor Technologies
- Cardiovascular Conditions and Treatments
- Olfactory and Sensory Function Studies
- Biosensors and Analytical Detection
- Hemodynamic Monitoring and Therapy
- Veterinary Oncology Research
- SARS-CoV-2 and COVID-19 Research
- Sports Performance and Training
- Frailty in Older Adults
- Veterinary Medicine and Surgery
- Nutrition and Health in Aging
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Spine and Intervertebral Disc Pathology
- SARS-CoV-2 detection and testing
- HIV Research and Treatment
- Cardiovascular Effects of Exercise
- Infectious Diseases and Mycology
- Agriculture and Rural Development Research
- Mechanics and Biomechanics Studies
- Congenital Heart Disease Studies
- Ultrasound in Clinical Applications
- HIV/AIDS drug development and treatment
École Nationale Vétérinaire d'Alfort
2016-2025
Institut Mondor de Recherche Biomédicale
2018-2025
Inserm
2005-2024
Université Paris-Est Créteil
2015-2024
Paris-Est Sup
2014-2018
Mécanismes Adaptatifs et Evolution
2013-2018
Centre National de la Recherche Scientifique
2015-2018
Structure et Instabilité des Génomes
2015
Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
2014
AgroParisTech
2010-2012
Taking into account a continuous exposure in regression models by using categorization, when non-linear dose-response associations are expected, have been widely criticized. As one alternative, restricted cubic spline (RCS) functions powerful tools (i) to characterize association between and an outcome, (ii) visually and/or statistically check the assumption of linearity association, (iii) minimize residual confounding adjusting for exposure. Because their implementation with SAS® software...
Background. Older healthy and HIV-infected adults exhibit physiological similarities. Frailty is a clinical syndrome associated with aging that identifies subset of older at high risk mortality other outcomes. We investigated whether HIV infection increases the prevalence frailty-related phenotype (FRP) approximates definition frailty.
Immunological similarities have been noted between HIV-infected individuals and older HIV-negative adults. Immunologic alterations with aging in frailty adults, a clinical syndrome of high risk for mortality other adverse outcomes. Using frailty-related phenotype (FRP), we investigated the Multicenter AIDS Cohort Study whether progressive deterioration immune system among HIV-positive independently predicts onset FRP.FRP was evaluated semiannually 1046 men from 1994 to 2005. CD4 T-cell count...
The health benefits of chronic caloric restriction resulting in lifespan extension are well established many short-lived species, but the effects humans and other primates remain controversial. Here we report most advanced survival data associated follow-up to our knowledge age-related alterations a cohort grey mouse lemurs (Microcebus murinus, lemurid primate) exposed moderate (30%) restriction. Compared control animals, extended by 50% (from 6.4 9.6 years, median survival), reduced...
The aim of this proof-of-concept study was to evaluate if trained dogs could discriminate between sweat samples from symptomatic COVID-19 positive individuals (SARS-CoV-2 PCR positive) and those asymptomatic negative individuals. conducted at 2 sites (Paris, France, Beirut, Lebanon), followed the same training testing protocols, involved six detection (three explosive dogs, one search rescue dog, two colon cancer dogs). A total 177 were recruited for (95 82 individuals) five hospitals,...
Background.In the general population, frailty, a late stage of aging process, predicts mortality. We investigated whether manifesting previously defined frailty-related phenotype (FRP) before initiating highly active antiretroviral therapy (HAART) affects likelihood developing clinical AIDS or mortality after HAART initiation.
French Bulldog (FB) has significantly gained in popularity over the last few years, and seems to be frequently affected by various neurological conditions. The purpose of this retrospective study was report prevalences diseases a large population FB, presented with signs between 2002 2016, for which definitive diagnosis established. A secondary objective identify epidemiological characteristics regarding specific singular breed. During period, 533 FBs were signs, representing 18.7% all...
Background Furosemide is the only loop diuretic recommended by ACVIM consensus guidelines for treatment of congestive heart failure (CHF) in dogs related to degenerative mitral valve disease (DMVD). Torasemide another potent with a longer half‐life and higher bioavailability. Objectives (1) To demonstrate that torasemide given once day (q24h) noninferior furosemide twice (q12h) treating CHF; (2) compare effect 2 drugs on time reach composite cardiac endpoint “spontaneous death, euthanasia...
Background Clinical assessment of intravascular volume status is challenging. In humans, ultrasonographic the inferior vena cava diameter, directly or as a ratio to aortic diameter used estimate status. Objectives To ultrasonographically obtain reference values (RV) for caudal (CVC D ), area ) and ratios using 3 views in awake healthy dogs. Animals One hundred twenty‐six adult dogs from clients, students, faculty, staff. Methods Prospective, multicenter, observational study. Two observer...
OBJECTIVE To define a frailty-related phenotype-a clinical syndrome associated with the aging process in humans-in aged dogs and to investigate its association time death. ANIMALS 116 guide dogs. PROCEDURES Dogs underwent geriatric assessment (CGA) were followed either of death or study cutoff date. A 5-component definition frailty phenotype was derived from items included health evaluation scoresheet completed by veterinarians during CGA. Univariate (via Kaplan-Meier curves) multivariate...
Objective To estimate scent dogs’ diagnostic accuracy in identification of people infected with SARS-CoV-2 comparison reverse transcriptase polymerase chain reaction (RT-PCR). We conducted a randomised triple-blinded validation trial, and real-life study at the Helsinki-Vantaa International Airport, Finland. Methods Four dogs were trained to detect COVID-19 using skin swabs from individuals tested for by RT-PCR. Our controlled comprised four identical sets 420 parallel samples (from 114...
To evaluate the evolution of corneal sensitivity in healthy beagle puppies during first weeks life, compare these results with adult sensitivity, and determine age at which levels are reached. Twelve five females. Corneal was assessed weekly from 2 to 7 their mothers by measuring touch threshold (CTT) central cornea using a Cochet-Bonnet esthesiometer. Hygrometric temperature measurements were recorded throughout study period. In puppies, esthesiometry indicated progressive decrease age....
Objective: With the current increase in sexually transmitted infections industrialized countries, we assessed characteristics and plasma viral load of HIV-1-infected patients reporting sexual behaviour at risk for HIV transmission (SBR). Design: The study population consisted 223 with primary HIV-1 infection who were enrolled French PRIMO cohort between 1996 2001 had least 3 months follow-up. Patients interviewed on condom use each visit according to partner (gender, steady versus casual...
Summary Reasons for performing study: Although beach training is commonly used in horses, limb loading on sand has never been investigated. A dynamometric horseshoe (DHS) well adapted this purpose. Objectives: To compare ground reaction force (GRF) and fetlock kinematics measured harness trotters 2 tracks of with different water content. Methods: Two linear were compared: firm wet (FWS, 19% moisture) vs. deep (DWS, 13.5% moisture). Four French (550 ± 22 kg) used. Their right forelimb was...
Background Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early are still lacking. Objectives To develop scoring system for prediction short‐term case fatality dogs AP. Animals One hundred sixty‐nine AP including 138 the training cohort and 31 validation cohort. Methods Multicenter, retrospective study. Survival analysis was used to assess associations (within 30 days after admission). Independent were identified by stepwise selection method...
Osteoarthritis is a significant and costly cause of pain for both humans horses. The horse has been identified as suitable model human osteoarthritis. Regenerative therapy with allogeneic mesenchymal stem cells (MSCs) promising treatment, but the safety this procedure continues to be debated. aim study evaluate intra-articular injections MSCs on healthy joints by comparing two different dosages tissue sources, namely, bone marrow umbilical cord blood, placebo treatment same individuals. We...
This study aimed to develop and validate a pain assessment scale for guinea pigs be performed in clinics by veterinarians. The was established using pre-existing scales from other species based on signs expressed already identified the literature. consists of 14 descriptors grouped into four categories: appearance, functional, physiological behavioral. Each item assigned score observation handling animals. total obtained ranged 0 26, with more intense scoring higher. Fifty-eight adult...
To evaluate the clinical and visual outcomes following intensive medical therapy for keratomalacia in dogs.Medical records were screened to identify dogs with corneal ulcers keratomalacia. All patients given same topical treatment protocol frequent administrations of tobramycin combination equine serum. Surgical during first 15 days follow-up was considered as failure.We report on 57 from 53 dogs. Medical successful 31 a median healing time 5 (range 2 days). At 60 after epithelialisation,...