A5064115377- Thyroid Disorders and Treatments
- Child Nutrition and Water Access
- Thyroid Cancer Diagnosis and Treatment
- Veterinary Oncology Research
- Immune Response and Inflammation
- Viral gastroenteritis research and epidemiology
- Infant Nutrition and Health
- Health and Lifestyle Studies
- Neonatal Respiratory Health Research
- Parasites and Host Interactions
- Ubiquitin and proteasome pathways
- Pneumonia and Respiratory Infections
- Public Health and Environmental Issues
- Antimicrobial Peptides and Activities
- Protein Degradation and Inhibitors
- Antibiotic Resistance in Bacteria
- Research on Leishmaniasis Studies
- Obesity, Physical Activity, Diet
- Parasite Biology and Host Interactions
- Peptidase Inhibition and Analysis
- Blood properties and coagulation
- Child and Adolescent Health
- Global Maternal and Child Health
- Renal Transplantation Outcomes and Treatments
- Respiratory viral infections research
Northwestern University
2024-2025
Universidad Peruana Cayetano Heredia
2012-2024
University of Bern
2018-2023
École Nationale Vétérinaire d'Alfort
2019
Inserm
2019
Institut Mondor de Recherche Biomédicale
2019
Ghent University
2010-2017
Complejo Hospitalario Torrecárdenas
2017
VA Caribbean Healthcare System
2016
Hospital de São João
2001-2014
The innate immune system plays a critical role in the defense of areas exposed to microorganisms. There is an increasing body evidence indicating that antimicrobial peptides and proteins (APs) are one most important weapons this they make up protective front for respiratory tract. On other hand, it known pathogenic organisms have developed countermeasures resist these agents such as reducing net negative charge bacterial membranes. Here we report characterization novel mechanism resistance...
Several case series have shown that reconstruction of the anterior or posterior periprostatic tissues facilitates early return urinary continence after radical prostatectomy. We conducted a randomized clinical trial comparing rates in patients undergoing urethrovesical anastomosis with without reconstruction.A total 116 consecutive computer assisted (robotic) prostatectomy performed by 1 2 experienced surgeons were to single (without reconstruction) double layer (with tissue anastomosis....
Abstract Background Adjuvant therapy to ORT with probiotic bacteria for infants acute watery diarrhea has been under active investigation. Most studies have done in the developed world showing benefit only viral mild gastroenteritis. We evaluated effect of a milk formula containing one billion (10 9 ) cfu/ml Lactobacillus casei strain GG (LGG) upon duration and severity an environment more severe diarrhea, where etiologic agents other than rotavirus are involved frequently, mixed infections...
Bismuth subsalicylate is a common constituent of over-the-counter medications for diarrhea. However, it uncertain whether bismuth offers any more benefit than standard oral rehydration therapy with early feeding.We conducted placebo-controlled, randomized trial to evaluate the effect (100 or 150 mg per kilogram body weight day up 5 days) on duration and volume acute watery diarrhea in 275 male infants young boys (mean age, 13.5 months). Serum salicylate levels were monitored throughout study...
ABSTRACT Antimicrobial peptides (APs) impose a threat to the survival of pathogens, and it is reasonable postulate that bacteria have developed strategies counteract them. Polymyxins are becoming last resort treat infections caused by multidrug-resistant Gram-negative and, similar APs, they interact with anionic lipopolysaccharide. Given polymyxins APs share initial target, possible bacterial defense mechanisms against will be also effective host APs. We sought determine whether exposure...
Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein.To determine the effect of bovine LF on prevention first episode late-onset sepsis in Peruvian infants.We conducted pilot randomized placebo-controlled double blind study infants with birth weight (BW) less than 2500g 3 Neonatal Units Lima. Patients were to receive 200mg/kg/d or placebo for 4 weeks.One hundred ninety neonates BW 1591 ± 408 g gestational age 32.1 2.6 weeks enrolled. Overall, 33...
We conducted a randomized, double-blind, placebo-controlled trial comparing supplementation with bovine lactoferrin versus placebo for the prevention of diarrhea in children. Comparison overall incidence and prevalence rates found no significant difference between 2 groups. However, there was lower colonization Giardia species better growth among children group.
ABSTRACT Airway epithelial cells act as the first barrier against pathogens. These recognize conserved structural motifs expressed by microbial pathogens via Toll-like receptors (TLRs) on surface. In contrast to level of expression in lymphoid cells, TLR2 and TLR4 airway is low under physiological conditions. Here we explored whether Klebsiella pneumoniae upregulates TLRs human cells. We found that A549 primary was upregulated upon infection with K. . The increased resulted enhancement...
Background Prognostic markers for dogs with thyroid tumors are limited. Hypothesis/Objectives To identify clinical, pathologic, and immunohistochemical prognostic factors tumors. Animals Seventy neoplasia. Methods Retrospective study. Dogs neoplasia were included when follow‐up information formalin‐fixed paraffin‐embedded tumor samples available. Immunohistochemistry ( IHC ) was performed thyroglobulin, calcitonin, Ki‐67, E‐cadherin. Correlation of variables (diameter, volume, localization,...
Background Acute pancreatitis (AP) is associated with a high death rate in dogs, but accurate predictors of early are still lacking. Objectives To develop scoring system for prediction short‐term case fatality dogs AP. Animals One hundred sixty‐nine AP including 138 the training cohort and 31 validation cohort. Methods Multicenter, retrospective study. Survival analysis was used to assess associations (within 30 days after admission). Independent were identified by stepwise selection method...
Objective. To test the hypothesis that high-dose vitamin A supplements will enhance recovery of children hospitalized for treatment community-acquired pneumonia. Design. We conducted a randomized, double-blind, placebo-controlled clinical trial among 3 months to 10 years age (N = 95) admitted hospital with pneumonia in Lima, Peru. Children ≤1 year received 100 000 IU water-miscible on admission and an additional 50 next day. >1 200 Results. receiving (n 48) had lower blood oxygen...
The means by which airway epithelial cells sense a bacterial infection and intracellular signalling pathways are activated upon poorly understood. A549 human primary (NHBE) were used to investigate the response with Klebsiella pneumoniae. Infection of NHBE K. pneumoniae 52K10, capsule polysaccharide (CPS) mutant, increased surface levels ICAM-1 caused release IL-8. By contrast, wild-type strain did not elicit these responses. Consistent functional role for responses, there was correlation...
OBJECTIVES. This study was conducted to determine whether poor hygiene practices are owing difficulty in getting enough water and/or ignorance of sanitary principles. METHODS. In a water-scarce shantytown Lima, Peru, we observed 12-hour periods over 3 consecutive days the amount and soap used for personal domestic activities 53 families frequency with which direct fecal contamination hands interrupted by washing. We also surveyed women similar concerning their knowledge ascertain...
This paper presents the first published report of a national-level effort to implement Integrated Management Childhood Illness (IMCI) strategy at scale. IMCI was introduced in Peru late 1996, early implementation phase started 1997, with expansion starting 1998. Here we on retrospective evaluation designed describe and analyze process taking scale Peru, conducted as one five studies within Multi-Country Evaluation Effectiveness, Cost Impact (MCE) coordinated by World Health Organization....
Conventional small-molecule drugs primarily operate by inhibiting protein function, but this approach is limited when proteins lack well-defined ligand-binding pockets. Targeted degradation (TPD) offers an alternative harnessing cellular pathways to eliminate specific proteins. Recent studies have expanded the potential of TPD identifying additional E3 ligases, with DCAF16 emerging as a promising candidate for facilitating through both proteolysis-targeting chimera (PROTAC) and molecular...
Background Information on the genetic events leading to thyroid cancer in dogs is lacking. Hypothesis/Objectives Upregulation of PI3K/Akt pathway has an important role tumorigenesis carcinoma dogs. Animals Fifty‐nine with and 10 healthy controls. Methods Quantitative RT ‐ PCR was performed for VEGFR‐1 , VEGFR‐2 EGFR PIK3CA PIK3CB PDPK1 PTEN AKT1 AKT2 COX‐2 CALCA . Mutation analysis known hotspots RAS (N K H) BRAF RET entire coding region Results Forty‐three (73%) had follicular cell ( FTC )...
High protein diets shift the faecal microbiota into a more unfavourable composition in obese humans. In lean dogs, higher consumption is accompanied with increased production of putrefactive fermentation products, whereas dogs have different gut compared to dogs. Still, impact high dietary on remains unclear. The aim this study was investigate microbial changes and response two levels protein. Six healthy six Beagles were fed diet (HP) low (LP) for 28 days each crossover design. Denaturing...
A randomized, open, controlled clinical trial was designed to evaluate the efficacy, tolerance, and safety of sodium stibogluconate plus allopurinol alone as treatment patients with mucocutaneous leishmaniasis. In phase 1 study, all 22 severe disease had improvement their lesions, but only two cure (both these received alone). 2, which included 59 moderate disease, rate among recipients 75% (21 28) compared 63.6% (14 22) recipients. The rates adverse events were similar both groups....