A5018252321- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Tracheal and airway disorders
- Antibiotic Resistance in Bacteria
- Restless Legs Syndrome Research
- Antimicrobial Peptides and Activities
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Vitamin D Research Studies
- RNA modifications and cancer
- Yersinia bacterium, plague, ectoparasites research
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thyroid Disorders and Treatments
- Breastfeeding Practices and Influences
- Bacterial biofilms and quorum sensing
- Inflammatory Biomarkers in Disease Prognosis
- Forensic and Genetic Research
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- Bacillus and Francisella bacterial research
- MicroRNA in disease regulation
- Sleep and related disorders
Health Research Institute of the Balearic Islands
2018-2025
Hospital Universitario Son Espases
2017
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2008-2011
Universitat de les Illes Balears
2006
ABSTRACT Antimicrobial peptides (APs) impose a threat to the survival of pathogens, and it is reasonable postulate that bacteria have developed strategies counteract them. Polymyxins are becoming last resort treat infections caused by multidrug-resistant Gram-negative and, similar APs, they interact with anionic lipopolysaccharide. Given polymyxins APs share initial target, possible bacterial defense mechanisms against will be also effective host APs. We sought determine whether exposure...
Rationale: Obstructive sleep apnea (OSA) is associated with increased cardiovascular disease (CVD) risk. Conversely, OSA has not been shown to increase recurrent events in patients acute coronary syndrome (ACS). This lack of homogeneity could suggest that the deleterious effect and its contribution CVD depend on specific patient profiles.Objectives: To evaluate risk for different ACS phenotypes.Methods:Post hoc analysis ISAACC (Continuous Positive Airway Pressure Patients OSA) study,...
A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other absence of OmpA. Our data suggest that OmpA is implicated in activation yet-unknown systems dedicated ameliorating AP cytotoxicity.
Obstructive sleep apnea (OSA) is common during pregnancy and linked to adverse outcomes. While oxidative stress a proposed pathogenic mechanism, evidence in pregnant populations remains limited. This multicenter, prospective study evaluated through protein carbonyl levels 171 women 86 cord blood samples. Polysomnography (PSG) performed categorized participants with the apnea–hypopnea index (AHI) OSA, rapid eye movement (REM) supine OSA. Protein were measured by dinitrophenyl hydrazine (DNPH)...
Rationale: Obstructive sleep apnea (OSA) during pregnancy is linked to negative maternal and neonatal outcomes. Diagnosing OSA in this population particularly challenging. Portable monitoring devices (PMD) present a potential alternative polysomnography (PSG), but their effectiveness pregnant women uncertain. Objective: To evaluate diagnostic accuracy of PMD detect women. Methods: A prospective study 136 middle-aged (34 ± 4 years) third trimester 3 weeks) who underwent laboratory type III...
Rationale: Obstructive sleep apnea (OSA) is prevalent in patients with acute coronary syndrome (ACS) and a cause of secondary hypertension. Objectives: To explore the long-term effects OSA continuous positive airway pressure (CPAP) treatment on blood (BP) ACS. Methods: Post hoc analysis ISAACC study (Continuous Positive Airway Pressure Patients Acute Coronary Syndrome Sleep Apnea; NCT01335087) included 1,803 admitted for (apnea–hypopnea index [AHI], ⩾15 events/h) were randomly assigned to...
Background: Obstructive sleep apnea (OSA) is prevalent in pregnancy and it associated with adverse pregnancy-related outcomes such as gestational diabetes, pre-eclampsia, low birth weight. Maternal systemic inflammation proposed to be one of the main intermediate mechanisms. However, effects OSA on are unknown normal pregnancy. Methods: Women 3rd trimester underwent hospital polysomnography evaluate whether increases its potential association fetal outcomes. was defined an apnea-hypopnea...
Red cell distribution width (RDW) is a parameter included in the complete blood count which informs about size of circulating red population and its distribution. In adults, an increase RDW was shown to be associated both with obstructive sleep apnoea (OSA) cardiovascular mortality. The aim this study determine whether potential biomarker for screening children moderate-severe OSA.An observational snoring patients performed. All underwent were classified either as simple snorers...
Prevalence of obstructive sleep apnea (OSA) in pregnancy is high and it has a significantly higher risk preeclampsia, hypertension, gestational diabetes adverse fetal outcomes. It been proposed that increased inflammation the main intermediate mechanism. However, there are no data on effect OSA systemic normal pregnancy. The aim was to investigate whether increases its potential association with 33 women 3rd trimester underwent hospital polysomnography. defined when apnea-hypopnea index...
OSA is common during pregnancy and associated with adverse perinatal consequences, but it not known whether can also modulate fetal development processes Methods. was identified by polysomnography defined as an apnea-hypopnea index ≥5 h-1. We included 5 non-OSA women. Cord blood RNA expression analyzed microarrays. To detect differentially expressed genes, a Gene Set Enrichment Analysis (GSEA) performed using GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes Genomes) WikiPathways...
<b>Introduction:</b> The obstructive sleep apnoea syndrome (OSA) is a multifactorial condition. It has been suggested as an independent risk factor for cardiovascular events and other cell death related diseases. However, the pathophysiological mechanisms underlying such relationships are not clear to date. During death, intracellular components leaked into bloodstream, so measurement of nucleosomes free double-stranded DNA (dsDNA) in serum could help understand this molecular high seen...
<b>Introduction:</b> Subjects with obstructive sleep apnea (OSA) have an increased risk of type 2 diabetes, hyperinsulinemia and metabolic syndrome. Pregnancy increases body weight, upper airway edema the OSA, however relationship between OSA gestational diabetes (GD) is unclear. <b>Objectives:</b> To determine if during pregnancy a factor for GD we performed case-control study. <b>Methods:</b> 177 women (89 GD, 88 controls) in third trimester underwent hospital polysomnography. was...