A5055711003- Veterinary Oncology Research
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Sarcoma Diagnosis and Treatment
- Microbial infections and disease research
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- dental development and anomalies
- Neuroblastoma Research and Treatments
- Surgical Sutures and Adhesives
- Lymphoma Diagnosis and Treatment
- Tracheal and airway disorders
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Neutropenia and Cancer Infections
- Immunodeficiency and Autoimmune Disorders
- Neuroendocrine Tumor Research Advances
- Genomics, phytochemicals, and oxidative stress
- Cutaneous lymphoproliferative disorders research
- Lymphatic System and Diseases
- Chronic Lymphocytic Leukemia Research
- Vascular Malformations and Hemangiomas
- Shoulder and Clavicle Injuries
Oregon State University
2017-2025
Texas A&M University
2024
The Ohio State University
2024
Colorado State University
2014-2018
Veterinary Medical Teaching Hospital
2018
University of Wisconsin–Madison
2018
Centre de Recherche en Sciences Animales de Deschambault
2018
University of Valley Forge
2018
University of Illinois Urbana-Champaign
2018
Colby College
2014
The updated VCOG-CTCAE v2 guidelines contain several important updates and additions since the last update (v1.1) was released in 2011 published within Veterinary Comparative Oncology 2016. As Cooperative Group (VCOG) is no longer an active entity, original authors contributors to v1.0 v1.1 were consulted for input, additional co-authors sought expansion refinement of adverse event (AE) categories. includes expanded neurology, cardiac immunologic AE sections, addition procedural-specific...
Standard of care treatment dogs with multicentric lymphoma includes combination chemotherapy cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP); however, owners may be hesitant to commit the resources necessary complete a lengthy, multi-drug protocol. One hundred thirty-four client-owned were treated 15-week CHOP The overall response rate was 98% 104 experiencing (CR). median progression-free survival (PFS) time for all 176 days, disease-specific 311 days. Prognostic factors...
Abstract Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition is biologically achievable with sirolimus, and might slow the outgrowth distant metastases. In this study, pet dogs appendicular osteosarcoma were leveraged high-value biologic models for pediatric osteosarcoma, to assess inhibition therapeutic strategy attenuating disease progression. Patients Methods: A total 324 diagnosed...
Objectives To report the clinical presentation, treatment and prognosis of dogs with low‐grade gastrointestinal lymphoma. Materials Methods Cases were solicited from American College Veterinary Internal Medicine Oncology Diplomate listserv. Medical records lymphoma diagnosed via a combination histology immunohistochemistry or without analysis polymerase chain reaction for antigen receptor rearrangement included. Signalment, signs, diagnostic test results, chemotherapy protocol, response to...
Myxosarcomas are known to be classified as soft tissue sarcomas. However, there is limited clinical characterization pertaining specifically canine cutaneous myxosarcomas in the literature. The objective of this study evaluate local recurrence rate, metastatic rate and prognosis myxosarcoma.A total 32 dogs diagnosed with myxosarcoma via histopathology were included retrospective study. All had surgical resection. No adjunct treatments performed 9 dogs, while 22 also received either radiation...
Abstract Lymphangiosarcomas are uncommon vascular neoplasms that arise from lymphatic endothelial cells (LECs). They efface and replace normal subcutaneous tissue characterised by arborising, channels lined a single layer of pleomorphic paucity erythrocytes. architecturally similar to hemangiosarcomas, common malignancy origin arising blood cells. Common immunohistochemical markers for endothelium, such as Factor VIII ‐related antigen (F8RA) CD31 , have traditionally been used confirm the...
Abstract Lymphangiosarcoma ( LAS ) is an uncommon malignant neoplasia arising from lymphatic endothelium; little information exists regarding therapy. Single institutional retrospective review for canine histopathology diagnoses over a 15‐year period yielded 12 dogs. Ten dogs were presented mass and/or swelling at cervical, trunk or limb regions. Prior to diagnosis, 10 received empiric wound Cytology performed in consisted of mild inflammation. Survival ranged 60, 168 and 876 days three with...
Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common haematopoietic malignancy in dogs. Recently, MYC and BCL2 expression levels determined with immunohistochemistry (IHC) were found to be prognostic people DLBCL. We hypothesized that canine DLBCL can similarly subdivided into subtypes based on of BCL2. Cases treated CHOP chemotherapy retrospectively collected 43 dogs had available histologic tissue complete clinical follow‐up. Median values percent immunoreactive versus...
Report clinical outcomes of dogs with surgically excised mast cell tumors (MCT) and soft tissue sarcomas (STS).Prospective study.Fifty-three 52 MCT (50 low grade, 2 high grade) 19 STS (12 grade I, 6 II, 1 III).All were examined at 3, 6, 12, 18, 24 months postoperatively, cytologic or histopathologic evaluation suspected local recurrences. Dogs euthanized because study tumor-related causes underwent necropsy.Median intraoperative margins 20 mm 30 wide for STS, respectively, fascial plane...
Abstract Background Dogs with lymphoma that fail cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (CHOP) before completion of their protocol are commonly thought to have poor long‐term outcome, but no previous studies evaluated the effect early relapse on progression‐free interval (PFI) or overall survival time (OST) for patients undergoing rescue chemotherapy. Objective Correlate treatment outcomes in dogs multicentric after 1st‐line CHOP Methods Data were collected...
Abstract Background B‐cell chronic lymphocytic leukemia (BCLL) in dogs generally is considered an indolent disease, but previous studies indicate a wide range survival times. Objectives We hypothesized that BCLL has heterogeneous clinical course, similar to humans. aimed assess presentation and outcome with evaluate the prognostic relevance of flow cytometric factors. Animals One hundred twenty‐one diagnosed by cytometry. Three breed groups were represented: small (n = 55) because increased...
A doxorubicin (DOX)-based chemotherapy protocol, CHOP, is the most effective treatment for canine high-grade B-cell lymphoma; however, cost and time requirements associated with this protocol are not feasible many pet owners. An alternative option use of DOX, drug, in combination prednisone. Prior studies single-agent DOX included dogs T-cell lymphoma, a known negative prognostic factor, which may have resulted shorter reported survival times than if lymphoma were analyzed separately. The...
Abstract Objective —To compare bursting pressures in canine jejunum, measured by use of an vitro and situ pressure technique. Study Population —Cadavers 3 healthy adult dogs. Procedures —54 enterotomies were performed on cadavers immediately after euthanasia. After completion enterotomy closure, was 9 jejunal segments technique for each cadaver. Bursting testing time recorded both techniques. Techniques compared means randomized block ANOVA. Results —The mean ± SE 93.63 24.10 mm Hg 141.19...
The role of epigenetic alterations during cancer has gained increasing attention and resulted in a paradigm shift our understanding mechanisms leading to susceptibility. Sulforaphane (SFN) is naturally occurring isothiocyanate derived from the precursor glucosinolate, glucoraphanin (GFN), which found cruciferous vegetables such as broccoli. been shown suppress tumour growth by several including inhibiting histone deacetylases. objective this study was provide detailed analysis sulforaphane...
While current lymphoma therapies induce remission in most dogs, drug-resistant relapse is common, creating a need for novel agents. Rabacfosadine (RAB), double prodrug of the acyclic nucleotide phosphonate 9-(2-phosphonylmethoxyethel) guanine (PMEG), preferentially targets cells with reduced systemic toxicity compared PMEG. Previous studies evaluating RAB administered every 21 days have suggested efficacy both naïve and relapsed subjects; however, no large as single agent been reported...
To determine the feasibility and agreement of margin assessment by imprint cytology, shaved histopathology, radial section histopathology in canine cutaneous subcutaneous mast cell tumors (MCT) soft tissue sarcomas (STS).Prospective clinical study.Three hundred forty margins from 72 excised (52 MCT 20 STS) 54 client-owned dogs.Imprint cytology samples were acquired pressing glass slides to cut surgical freshly specimen. Shaved obtained patient wound bed using a scalpel immediately prior...
Quantify changes in the circumferential lengths of surgical margins resected canine mast cell tumors (MCT) and soft tissue sarcomas (STS) between time collection histopathology.Prospective, hypothesis-driven, clinical study.Two hundred thirty-seven from 69 excised (50 MCT 19 STS) 51 client-owned dogs.The were recorded (eg, cranial, caudal, dorsal, ventral) for each tumor at 5 points: intraoperatively (in vivo), immediately after excision (ex formalin fixation (postfixation), once mounted on...
Lymphocytosis is relatively common in cats, but few studies describe lymphocyte populations or the clinical course associated with different immunophenotypic expansions.We hypothesized that cats frequently develop non-neoplastic lymphocytosis and neoplastic immunophenotypes have variable prognoses. We aimed to characterize expansions a large population of assess presentation outcome subset.Three cohorts older than 1 year (>6000/μL) were examined define categories (n = 146), evaluate 94),...
Abstract A 9‐year‐old spayed female Curly Coated Retriever was referred for evaluation of generalized peripheral lymphadenomegaly. The dog clinically healthy on presentation with no anomalies detected complete blood count, serum biochemistry, urinalysis, or three‐view thoracic radiographs. Fine‐needle aspiration ( FNA ) and cytology the lymph nodes were consistent lymphoma an intermediate‐sized lymphoid population. Flow cytometry a homogeneous population CD 4 + T cells that had lost...
Abstract Background Metastasis of appendicular osteosarcoma is most common to the lungs and generally considered a terminal event in dogs. Behavior prognosis associated with cutaneous or subcutaneous metastases (CSM) poorly defined. Objective Describe population gather prognostic information regarding CSM Animals Twenty dogs CSM. Methods Retrospective case series. Medical records were searched identify diagnosed that developed Demographic data, order metastatic events, clinical features...
Abstract Fasting has been shown to decrease chemotherapy‐associated adverse events (AEs), in part through insulin‐like growth factor (IGF‐1) reduction, and may induce a protective effect on normal cells during chemotherapy treatment mice people. The purpose of this study was evaluate the fasting constitutional, bone marrow gastrointestinal (GI) AEs, serum glucose, IGF‐1 insulin levels dogs receiving vincristine. prospective, crossover clinical trial tumour‐bearing dogs. Dogs were randomized...