A5061691552- Horticultural and Viticultural Research
- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- French Urban and Social Studies
- Diabetic Foot Ulcer Assessment and Management
- Oral microbiology and periodontitis research
- Bacterial biofilms and quorum sensing
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Social Sciences and Governance
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 and COVID-19 Research
- Body Contouring and Surgery
- Agriculture and Rural Development Research
- Antimicrobial Peptides and Activities
- Plant Pathogens and Fungal Diseases
- Fermentation and Sensory Analysis
- Nursing Roles and Practices
- RNA and protein synthesis mechanisms
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Forest Insect Ecology and Management
- Aging, Elder Care, and Social Issues
- Genomics and Phylogenetic Studies
- COVID-19 Clinical Research Studies
Comité Champagne
2018-2024
University of Toronto
2007-2024
Public Health Ontario
2022-2024
Access to Wholistic and Productive Living Institute
2022
Vanderbilt University
2022
St. Michael's Hospital
2016-2020
McMaster University
2006-2017
University of Rome Tor Vergata
2011
Policlinico Tor Vergata
2011
Hospital for Sick Children
2005-2007
Antibiotic resistance is an ancient problem, owing to the co-evolution of antibiotic-producing and target organisms in soil other environments over millennia. The environmental "resistome" collection all genes that directly or indirectly contribute antibiotic resistance. Many these determinants originate (where they serve mediate self-immunity), while others become only when mobilized over-expressed non-native hosts (like plasmid-encoded β-lactamases). modern resistome under selective...
Summary The induction of genetic competence is a strategy used by bacteria to increase their repertoire under stressful environmental conditions. Recently, Streptococcus pneumoniae has been shown co‐ordinate the uptake transforming DNA with fratricide via increased expression peptide pheromone responsible for induction. Here, we document that stress‐induced competence‐stimulating (CSP) in oral pathogen mutans . We showed CSP involved stress response and determined CSP‐induced regulon S....
Streptococcal competence-stimulating peptides (CSPs) were once thought to passively communicate population density in a process known classically as quorum sensing. However, recent evidence has shown that these may also be inducible 'alarmones,' capable of conveying sophisticated messages including the induction altruistic cellular suicide under stressful conditions. We have previously characterized alarmone response Streptococcus mutans, cariogenic resident oral flora, which novel...
Bacteria living in the human gut are implicated etiology of several diseases. Moreover, dozens drugs metabolized by elements microbiome, which may have further implications for health. Here, we screened a collection isolates their ability to inactivate widely used antineoplastic drug doxorubicin and identified strain Raoultella planticola as potent inactivator under anaerobic conditions. We demonstrate that R. deglycosylates metabolites 7-deoxydoxorubicinol 7-deoxydoxorubicinolone via...
No AccessJournal of UrologyAdult urology1 Feb 2006Systematic Review the Diagnosis and Management Malignant Extradural Spinal Cord Compression: The Cancer Care Ontario Practice Guidelines Initiative’s Neuro-Oncology Disease Site Group D.A. Loblaw, J. Perry, A. Chambers, N.J. Laperriere LoblawD.A. Loblaw More articles by this author , PerryJ. Perry ChambersA. Chambers LaperriereN.J. View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)00280-6AboutFull TextPDF ToolsAdd to...
In Streptococcus pneumoniae, competence and bacteriocin genes are controlled by two two-component systems, ComED BlpRH, respectively. mutans, both functions the system. Recent studies in S. mutans revealed a potential ComE binding site characterized 11 bp direct repeats shared each of responsive to competence-stimulating peptide (CSP). Interestingly, this sequence was not found upstream region CSP structural gene comC. Since comC is suggested be part CSP-responsive ComE-dependent...
Diabetic foot ulcers (DFUs) are a significant problem in an aging population. Fifteen percent of diabetics develop DFU over their lifetime, which can lead to potential amputation. The 5-year survival rate after amputation is 31%, greater than the lifetime risk mortality from cancer. Topical oxygen promising technique for adjunctive therapy chronic wounds including DFUs, but few controlled studies exist support its clinical adoption. aim this study was compare portable topical delivery system...
Abstract Quantifying healthy and degraded inner tissues in plants is of great interest agronomy, for example, to assess plant health quality monitor physiological traits or diseases. However, detecting functional in-vivo without harming the extremely challenging. New solutions are needed ligneous perennial species, which sustainability plantations crucial. To tackle this challenge, we developed a novel approach based on multimodal 3D imaging artificial intelligence-based image processing...
To assess potential function of each two-component signal transduction system in the expression Streptococcus mutans virulence properties.For (TCS), histidine kinase-encoding gene was inactivated by a polymerase chain reaction (PCR)-based deletion strategy and effects disruption on cell's ability to form biofilms, become competent, tolerate acid, osmotic, oxidative stress conditions were tested. Our results demonstrated that none mutations lethal for S. mutans. The TCS-2 (CiaRH) is involved...
People with diabetes are at risk for diabetic foot ulcers (DFUs), which can lead to limb loss and a significant decrease in quality of life. Evidence suggests that mHealth be an effective tool self-management. presents opportunity the prevention monitoring DFUs. However, there is paucity research explores its effectiveness DFU patient population, as well views attitudes these patients toward technology mHealth.This study aimed explore views, attitudes, experiences population or DFUs...
The intermediate protein nestin is expressed in proliferating embryonic tissues and adult undergoing repair. Recently this been identified rodent podocytes. Its role cell unknown, since podocytes are believed to be terminally differentiated nondividing. We report the first study of human kidney. Nestin expression normal mature glomeruli was confined In developing kidney, detected metanephric blastema podocytic cells at all stages glomerular development. co-localized with vimentin but not...
Bone marrow-derived stromal stem cells (BMSC) can differentiate along a variety of mesenchymal lines, including mesangial cells. For determining whether BMSC be induced to podocytic lines in vitro, canine were cultured on plastic, type I collagen, and NC1 hexamers IV collagen from normal Alport glomerular basement membrane. Results compared with mouse podocyte cell line. In the case line, differentiation occurred all three matrices as indicated by expression synaptopodin CD2-associated...
ABSTRACT The incidence of antibiotic resistance among pathogenic microorganisms is increasing at an alarming rate. Resistance against front-line therapeutics such as the glycopeptide vancomycin has emerged and spread to highly virulent pathogens, including Staphylococcus aureus . Glycopeptide antibiotics are natural products from Actinomycetes that have a characteristic heptapeptide core. chemical diversity class achieved through glycosylation, halogenation, methylation, acylation core,...
Background: Complications of the diabetic lower extremity (such as foot ulcers, DFUs) occur when monitoring is infrequent, and often result in serious sequelae like amputation or even death. Objective: To evaluate potential application mobile health (mHealth) to monitoring. We surveyed self-management routines a group patients, well patient clinician opinions on use mHealth this context. Methods: Patients with DFUs Toronto, Ontario, Canada completed 25-item questionnaire addressing their...
To identify the genes regulated by RR11, regulator of Streptococcus mutans HK/RR11 two-component system.The S. RR11-encoding gene was inactivated, and effects disruption on cell's ability to form biofilms under stresses acquire extracellular DNA were tested. Biofilm reduced in cells lacking RR11 following exposure oxidative stress. RR11-defective showed approx. 20-fold reduction transformation efficiency. Microarray used decipher RR11-regulated biofilm that 5% UA159 genome underwent a...