A5058723984- Veterinary Oncology Research
- Virus-based gene therapy research
- Sarcoma Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Cancer Research and Treatments
- Infectious Diseases and Mycology
- Oral and Maxillofacial Pathology
- Microbial Inactivation Methods
- Tumors and Oncological Cases
- Hedgehog Signaling Pathway Studies
- Pulsed Power Technology Applications
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Histiocytic Disorders and Treatments
- Microbial infections and disease research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Extracellular vesicles in disease
- Microfluidic and Bio-sensing Technologies
- TGF-β signaling in diseases
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Cancer Treatment and Pharmacology
Virginia–Maryland College of Veterinary Medicine
2013-2025
Virginia Tech
2014-2025
Purdue University West Lafayette
2025
Carilion Clinic
2021-2023
University of Wisconsin–Madison
2022
Colorado State University
2013-2020
Universidade de São Paulo
2018
Michigan State University
2004-2017
IVDiagnostics (United States)
2013
Texas Oncology
2008
There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of number treatment options, the increased financial costs associated with treatment, emotional stress experienced by owners association disease its treatment. Numerous studies have evaluated potential neoplastic diseases, but there are no established guidelines or standards conduct reporting medicine. This lack standardization has made evaluation comparison difficult. Most...
Abstract Objective —To evaluate and compare the outcomes of dogs with periarticular histiocytic sarcoma (PAHS) other anatomic locations (non-PAHS) identify factors associated outcome for PAHS. Design —Retrospective cohort study. Animals —19 PAHS 31 non-PAHS. Procedures —Medical records that underwent definitive local treatment (surgery or radiation), chemotherapy, a combination these were reviewed. Patient signalment, clinical signs, staging test results, clinicopathologic data, type...
Abstract Canine histiocytic sarcoma ( HS ) is an aggressive neoplasia with variable clinical course and fatal outcome. The goals of this study were to evaluate a large cohort canine patients immunohistochemically confirmed identify prognostic factors. Biopsy submissions the Michigan State University tentative diagnoses histologically confirmed, medical records collected, interviews relevant veterinary clinics conducted. Of 1391 histopathology diagnosis containing word ‘histiocytic’, 335...
Standardization of tumor assessment lays the foundation for validation grading systems, permits reproducibility oncologic studies among investigators, and increases confidence in significance study results. Currently, there is minimal methodological standardization assessing tumors veterinary medicine, with few attempts to validate published protocols schemes. The current article address these shortcomings by providing standard guidelines parameters evaluating specific types. More detailed...
Abstract Purpose: The mTOR pathway has been identified as a key nutrient signaling hub that participates in metastatic progression of high-grade osteosarcoma. Inhibition is biologically achievable with sirolimus, and might slow the outgrowth distant metastases. In this study, pet dogs appendicular osteosarcoma were leveraged high-value biologic models for pediatric osteosarcoma, to assess inhibition therapeutic strategy attenuating disease progression. Patients Methods: A total 324 diagnosed...
Histiocytic sarcoma is an uncommon malignancy in both humans and veterinary species. Research exploring the pathogenesis of this disease scarce; thus, diagnostic therapeutic options for patients are limited. Recent publications have suggested a role NLR, NLRX1, acting as tumor suppressor. Based on these prior findings, we hypothesized that NLRX1 would function to inhibit tumorigenesis thus development histiocytic sarcoma. To test this, utilized Nlrx1-/- mice model urethane-induced...
The current standard of care for treatment intermediate–large B-cell lymphoma in dogs is a CHOP-based chemotherapy protocol. On-protocol disease progression reported to be temporally associated with cyclophosphamide administration. objectives this prospective pilot clinical trial were describe the adverse event profile and identify early signal efficacy novel cyclophosphamide-free protocol consisting temozolomide, doxorubicin, vincristine, prednisone (THOP) as first-line diffuse large cell...
Abstract Background: High-Frequency Irreversible Electroporation (H-FIRE) is a non-thermal tissue ablation technique that induces cell death by destabilizing the membrane. This innovative approach has demonstrated significant potential in cancer treatment and been associated with modulation of tumor microenvironment both vivo vitro settings. Recent findings from our lab reveal extracellular vesicles (EVs) released cells lethally treated H-FIRE exhibit unique proteomic profile. These EVs may...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Introduction:</i> Histotripsy is a non-invasive focused ultrasound therapy that uses controlled acoustic cavitation to mechanically disintegrate tissue. To date, there are no reports investigating histotripsy for the treatment of soft tissue sarcoma (STS). xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> This study aimed investigate xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i>...
Abstract Objective —To compare results of treatment with temozolomide or dacarbazine, in combination an anthracycline, dogs relapsed refractory lymphoma. Design —Nonrandomized, controlled clinical trial. Animals —63 Procedures —Chemotherapy was administered 21-day cycles. A and anthracycline (doxorubicin dactinomycin) to 21 a dacarbazine 42 dogs. Efficacy toxicoses were assessed. Results —Thirteen the 18 (72%) treated temozolomide-anthracycline 25 35 (71%) dacarbazine-anthracycline had...
Hemangiosarcoma (HSA) is an aggressive disease that fairly common in the dog. The authors evaluated a doxorubicin, dacarbazine, and vincristine (DAV) combination protocol dogs with nonresectable stage II III HSA. Twenty-four were enrolled this prospective, phase 2 study. Doxorubicin dacarbazine administered on day 1 while was days 8 15. repeated every 21 for maximum of six cycles or until progression. Toxicity efficacy assessed by clinical laboratory evaluation questionnaires completed...
Objectives: To review the presenting clinical signs, treatment and survival of dogs with tonsillar squamous cell carcinoma and, if possible, to identify useful prognostic indicators. Methods: Medical records 44 were reviewed retrospectively. Clinical stage, time diagnosis, outcome recorded. Data analysed using Kaplan-Meier, log-rank, Student's t test, Kruskal-Wallis test Chi-square/Fisher Exact as appropriate. Results: The most frequent signs cough (12 dogs, 27%), enlarged lymph nodes (11...
An image-guided robotic stereotactic radiosurgery (SRS) system can be used to deliver curative-intent radiation in either single fraction or hypofractionated doses. Medical records for 19 dogs with nonlymphomatous nasal tumors treated body radiotherapy (SBRT), without adjunctive treatment, were retrospectively analyzed survival and prognostic factors. Median time (MST) was evaluated using Kaplan-Meier curves. Age, breed, tumor type, stage, size, prescribed dose, heterogeneity index...
Background: Response and adverse reactions to combined gemcitabine (GEM) carboplatin (CARBO) therapy in dogs with carcinomas are not documented. Hypothesis: GEM CARBO safe for the treatment of carcinomas. Animals: Thirty‐seven histologically or cytologically confirmed Methods: Prospective clinical trial. Dogs were treated (2 mg/kg, 20–30‐minute infusion IV) on Days 1 8 4 hours later, (10 mg/kg Day 1. The cycle was repeated 22. Results: (29 measurable tumor) received a median 2 cycles (range...
To characterize the expression of P-glycoprotein (Pgp) and p53 in different histologic grades canine multicentric lymphosarcoma (LSA), 31 cases LSA without prior treatment were studied. The levels Pgp proteins evaluated for their clinicopathologic significance among standard evaluation. Immunohistochemistry (IHC) was performed on formalin-fixed, paraffin-embedded archival samples previously untreated to detect p53. All dogs subsequently treated with a combination chemotherapy protocol....
This study was performed to determine the toxicity of gemcitabine-carboplatin doublet therapy in cats with carcinomas.Gemcitabine and carboplatin are safe tumor-bearing cats.Twenty spontaneously occurring carcinomas.A cohort 6 received gemcitabine (2 mg/kg IV) on days 1, 8, 15 (10 immediately after day 1 a 21-day cycle. A 2nd 14 4 hours 8 but not 15. The cycles were repeated every 21 days.Cats 1st median 3.75 per animal (range, 1-6). Two (33.3%) developed grade 3 or neutropenia, (16.7%)...
Purpose To investigate the safety, feasibility, and outcomes of High-Intensity Focused Ultrasound (HIFU) for treatment solid tumors in a spontaneous canine cancer model.Methods Dogs diagnosed with subcutaneous were recruited, staged pretreatment biopsies obtained. A single HIFU was delivered to result partial tumor ablation using commercially available unit. Tumors resected 3–6 days post samples obtained histopathology immunohistochemistry. Total RNA isolated from paired pre treated FFPE...
Purpose Feline soft tissue sarcoma (STS) and injection site (fISS) are rapidly growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. In this study, we investigated the in vivo safety feasibility of histotripsy treat fISS custom 1 MHz transducer.Materials Methods Three cats naturally-occurring STS were treated before surgical removal tumor...
The purpose of this study was to describe abdominal ultrasonographic findings present at diagnosis osteosarcoma (OSA) in dogs and investigate for associations with treatment outcome. Medical records from 118 diagnosed OSA that had ultrasonography performed as part their initial evaluation were reviewed. Fifty-seven percent abnormalities identified. organ the highest frequency changes spleen. While most sonographic considered be either benign or unknown clinical consequences, metastases...