A5035057482- Virus-based gene therapy research
- Veterinary Oncology Research
- Ultrasound and Hyperthermia Applications
- Fibroblast Growth Factor Research
- RNA Interference and Gene Delivery
- Tendon Structure and Treatment
- Amphibian and Reptile Biology
- Environmental DNA in Biodiversity Studies
- Sarcoma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- Species Distribution and Climate Change
- Silk-based biomaterials and applications
- Nanoparticle-Based Drug Delivery
- Healthcare and Venom Research
- Advanced MRI Techniques and Applications
- Insect symbiosis and bacterial influences
- Cancer Research and Treatments
Virginia Tech
2023-2025
Gettysburg College
2022-2025
Virginia–Maryland College of Veterinary Medicine
2023
Symbiosis is a commonly occurring phenomenon, with most plants and animals being holobionts, comprising of host its corresponding symbionts. It is, however, less common to have symbiont only under specific life stage even more so between photosynthesizing organism vertebrate animal. One such relationship found the unicellular green algae Oophila amblystomatis North American yellow‐spotted salamander Ambystoma maculatum , which far known endosymbiotic an alga vertebrate. In this study we...
Osteosarcoma (OS) is a malignant bone tumor treated by limb amputation or salvage surgeries and chemotherapy. Histotripsy non-thermal, non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. Recent ex vivo in pilot studies have demonstrated the ability of histotripsy for ablating OS but were limited scope. This study expands on these initial findings more fully characterize effects tumors, particularly tumors with different...
Purpose Feline soft tissue sarcoma (STS) and injection site (fISS) are rapidly growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. In this study, we investigated the in vivo safety feasibility of histotripsy treat fISS custom 1 MHz transducer.Materials Methods Three cats naturally-occurring STS were treated before surgical removal tumor...
Background Osteosarcoma (OS) is the most frequently occurring primary bone tumor in dogs and people innovative treatment options are profoundly needed. Histotripsy an emerging ablation modality, it essential for clinical translation of histotripsy to gain knowledge about outcome nonablated cells that could remain postablation. The objective this study was characterize cell death genetic signature proliferation response canine OS post a near complete (96% ± 1.5) evaluate signatures associated...
Osteosarcoma (OS) is the most common primary bone tumor in dogs and humans considered an immunologically "cold" tumor. OS exerts devastating impacts on patients has not seen significant improvements survival outcomes decades, with resistant metastatic disease remaining a main cause of death. Innovative therapies are profoundly needed to improve treatment OS. Canine shares striking similarities human but occurs at greater prevalence, allowing dog serve as valuable comparative oncology...
Objective Brain tumors represent some of the most treatment refractory cancers, and there is a clinical need for additional treatments these tumors. Domesticated dogs are only other mammalian species which commonly develop spontaneous brain tumors, making them an ideal model investigating novel therapies. Histotripsy non-thermal ultrasonic ablation method that emulsifies tissue through acoustic cavitation. The primary objectives this prospective study were to assess feasibility safety...
Abstract Background: Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, known for its aggressive nature high potential metastasis. Despite standard of care, 5-year survival rate OS patients remains at 60%-70%, with cause death being metastatic disease. Histotripsy, an emerging non-invasive, non-thermal, non-ionizing ablation technique, uses high- intensity focused ultrasound to mechanically destroy tissues. This process can release...
Abstract Background: Osteosarcoma (OS) is the most common primary malignant bone tumor in humans primarily occurring children and adolescents. OS an aggressive cancer typically classified as “immunologically cold” with microenvironment (TME) characterized immune desert. In a similar fashion to other cancers, lack of recognition allows disease progress eventually resulting metastatic disease. Prognosis for human patients without at time diagnosis who undergo definitive standard care 70%...
<p>Feline soft tissue sarcoma (STS) and injection site (fISS) are rapidly growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. In this study, we investigated the <em>in vivo</em> safety feasibility of histotripsy treat fISS custom 1 MHz transducer. Three cats naturally-occurring STS were treated before surgical removal...
<p>Feline soft tissue sarcoma (STS) and injection site (fISS) are rapidly growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. In this study, we investigated the <em>in vivo</em> safety feasibility of histotripsy treat fISS custom 1 MHz transducer. Three cats naturally-occurring STS were treated before surgical removal...
<p>Feline soft tissue sarcoma (STS) and injection site (fISS) are rapidly growing tumors with low metastatic potential, but locally aggressive behavior. Histotripsy is a non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. In this study, we investigated the <em>in vivo</em> safety feasibility of histotripsy treat fISS custom 1 MHz transducer. Three cats naturally-occurring STS were treated before surgical removal...
Abstract Osteosarcoma (OS) is the most common primary bone cancer in humans and dogs. Canine OS shares many biological similarities with human a valuable comparative oncology research model. In both species, metastasis remains major hurdle against improved survival, thus warranting novel therapeutic approach such as histotripsy, non-thermal, non-invasive, focused ultrasound ablation modality. Histotripsy can mechanically disintegrate gross tumor potentially induces an anti-tumor immune...
Abstract Osteosarcoma (OS), the most commonly occurring primary bone tumor in dogs and humans, has deficient treatment options dismal survival outcomes. Spontaneously OS shares numerous similarities with humans greater prevalence, allowing dog to serve as an informative comparative oncology model. The objective of this study was investigate non-thermal focused ultrasound technique histotripsy innovative option for OS. Histotripsy potential both ablate stimulate antitumor immune response...