A5091714695- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Spinal Fractures and Fixation Techniques
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurofibromatosis and Schwannoma Cases
- Vascular Malformations Diagnosis and Treatment
- Surgical Simulation and Training
- Intraoperative Neuromonitoring and Anesthetic Effects
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Nanoplatforms for cancer theranostics
- Advanced Radiotherapy Techniques
- Neurological disorders and treatments
- Anatomy and Medical Technology
- Fetal and Pediatric Neurological Disorders
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
Neurological Surgery
2018-2025
Focused Ultrasound Foundation
2017-2025
University of Virginia Health System
2019-2025
Fondazione IRCCS Istituto Neurologico Carlo Besta
2015-2024
University of Virginia
2017-2024
Aziende Socio Sanitarie Territoriali di Lecco
2021
Alessandro Manzoni Hospital
2021
Johns Hopkins University
2018-2019
Medical University of Vienna
2019
Austrian Center for Medical Innovation and Technology
2019
Abstract The updated version of the EFSUMB guidelines on application non-hepatic contrast-enhanced ultrasound (CEUS) deals with use microbubble contrast outside liver in many established and emerging applications.
Abstract The updated version of the EFSUMB guidelines on application non-hepatic contrast-enhanced ultrasound (CEUS) deals with use microbubble contrast outside liver in many established and emerging applications.
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a dynamic and continuous modality that offers real-time, direct view of vascularization patterns tissue resistance for many organs. Thanks to newer contrast agents, CEUS has become well-established, live-imaging technique in contexts, but it never been used extensively brain imaging. The use intraoperative (iCEUS) imaging neurosurgery limited. OBJECTIVE: To provide the first iCEUS evaluation variety lesions. METHODS: We evaluated 71 patients...
OBJECTIVE The purpose of this study was to assess the capability contrast-enhanced ultrasound (CEUS) identify residual tumor mass during glioblastoma multiforme (GBM) surgery, increase extent resection. METHODS authors prospectively evaluated 10 patients who underwent surgery for GBM removal with navigated guidance. Navigated B-mode and CEUS were performed prior resection, after complete Areas suspected tumors on studies localized within surgical field samples sent separately...
<b>Purpose:</b> Brain shift and tissue deformation during surgery for intracranial lesions are the main actual limitations of neuro-navigation (NN), which currently relies mainly on preoperative imaging. Ultrasound (US), being a real-time imaging modality, is becoming progressively more widespread neurosurgical procedures, but most neurosurgeons, trained axial computed tomography (CT) magnetic resonance (MRI) slices, lack specific US training have difficulties recognizing anatomic structures...
Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization flow distribution patterns different organs tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, thorough characterization cerebral glioma had never before.To perform the first using CEUS to possibly achieve an differentiation gliomas.We in off-label setting 69 patients undergoing surgery glioma. An qualitative analysis was...
Introduction: Glioma surgery is aimed at obtaining maximal safe tumor resection while preserving or improving patient's neurological status. For this reason, there growing interest for intra-operative imaging in neuro-oncological surgery. Intra-operative ultrasound (ioUS) provides the surgeon with real-time, anatomical and functional information. Despite this, neurosurgery ioUS mainly relies only on gray-scale brightness mode (B-mode). Many other modalities, such as Fusion Imaging...
Purpose To compare contrast material enhancement of glioblastoma multiforme (GBM) with intraoperative contrast-enhanced ultrasonography (US) versus that preoperative gadolinium-enhanced T1-weighted magnetic resonance (MR) imaging by using real-time fusion imaging. Materials and Methods Ten patients GBM were retrospectively identified routinely collected, anonymized data. Navigated US was performed after intravenous administration before tumor resection. All underwent excision navigated...
Sonoelastography is an ultrasound imaging technique able to assess mechanical properties of tissues. Strain elastography (SE) a qualitative sonoelastographic modality with wide range clinical applications, but its use in brain tumor surgery has been so far very limited.To describe the first large-scale implementation SE oncological neurosurgery for lesions discrimination and characterization.We analyzed retrospective data from 64 patients aiming at (i) evaluating stiffness lesion surrounding...
Fluorescein-mediated sonodynamic therapy (FL-SDT) is an extremely promising approach for glioma treatment, resulting from the combination of low-intensity focused ultrasound (FUS) with a sonosensitizer. In present study, we evaluated efficacy and immunomodulation SDT fluorescein as sonosensitizer in immunocompetent GL261 mice first time. vitro studies demonstrated that exposure cells to FL-SDT induced immunogenic cell death relevant upregulation MHC class I, CD80 CD86 expression. vivo were...
Object. A grading system, called the Clinical—Radiological Grading System (CRGS), has been developed to standardize surgical indications in elderly patients harboring intracranial meningiomas. Patients with a score lower than 10 had bad prognosis regardless of treatment, those between and 12 positively influenced by surgery, higher good treatment. The authors performed prospective cross-sectional study validate further use CRGS as clinical tool orientate decision making explore prognostic...
Abstract BACKGROUND Maximizing extent of resection (EOR) and reducing residual tumor volume (RTV) while preserving neurological functions is the main goal in surgical treatment gliomas. Navigated intraoperative ultrasound (N-ioUS) combining advantages conventional neuronavigation (NN) allows for overcoming limitations latter. OBJECTIVE To evaluate impact real-time NN ioUS preoperative magnetic resonance imaging (MRI) on maximizing EOR glioma surgery compared to standard NN. METHODS We...