A5067400065- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Spine and Intervertebral Disc Pathology
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Epilepsy research and treatment
- Anatomy and Medical Technology
- Vagus Nerve Stimulation Research
- MRI in cancer diagnosis
- Surgical Simulation and Training
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Neuroblastoma Research and Treatments
- Neurosurgical Procedures and Complications
- Head and Neck Surgical Oncology
- Immune cells in cancer
- Advanced Neuroimaging Techniques and Applications
- Spinal Dysraphism and Malformations
FHU Neurovasc
2021-2025
Institut de Psychiatrie et Neurosciences de Paris
2021-2025
Université Paris Cité
2021-2025
Inserm
2021-2025
Centre Hospitalier Sainte-Anne
2020-2025
Sorbonne Paris Cité
2021-2025
Délégation Paris 5
2024-2025
GHU Paris psychiatrie & neurosciences
2021-2024
Fondation Ophtalmologique Adolphe de Rothschild
2023
Collège de France
2023
BACKGROUND AND OBJECTIVES: We assessed the impact of ventricular opening on postoperative complications and survival carmustine wafer implantation during surgery newly diagnosed supratentorial glioblastomas, isocitrate dehydrogenase ( IDH )-wildtype in adults. METHODS: performed an observational, retrospective, single-center cohort study at a tertiary surgical neuro-oncological center between January 2006 December 2021. RESULTS: One hundred ninety-four patients who benefited from first-line...
BACKGROUND AND OBJECTIVES: The risk-to-benefit ratio of transopercular awake resection for recurrent insular diffuse gliomas is poorly studied. We assessed feasibility, safety, and efficacy surgical in patients with previous treatments (resection and/or radiotherapy chemotherapy combination). METHODS: Observational, retrospective, single-institution cohort analysis (2010-2023) 123 consecutive adult operated on an glioma (2021 World Health Organization classification) under conditions....
Abstract Objective Vagus nerve stimulation (VNS) is an established therapy for drug‐resistant epilepsy (DRE) and indicated implantation on the left vagus nerve‐only. In rare cases right‐sided VNS may be only option. With seven published in literature, data safety effectiveness of very limited. Methods An anonymous 38‐item questionnaire was sent to expert surgeons implanting DRE. The questions covered demographics clinical characteristics, reason both neurological surgical outcomes VNS....
Abstract BACKGROUND Maximizing extent of resection (EOR) and reducing residual tumor volume (RTV) while preserving neurological functions is the main goal in surgical treatment gliomas. Navigated intraoperative ultrasound (N-ioUS) combining advantages conventional neuronavigation (NN) allows for overcoming limitations latter. OBJECTIVE To evaluate impact real-time NN ioUS preoperative magnetic resonance imaging (MRI) on maximizing EOR glioma surgery compared to standard NN. METHODS We...
OBJECTIVE The 2021 WHO classification of CNS tumors has refined the definition adult-type diffuse gliomas without 1p19q codeletion. Nevertheless, aggressiveness is based exclusively on histomolecular criteria performed a limited sample tumor. authors aimed to assess whether spontaneous radiographic tumor growth rate associated with and allows preoperative identification malignancy grade METHODS retrospectively reviewed records adult patients harboring newly diagnosed supratentorial glioma...
<h3>Background and Objectives</h3> The association between levetiracetam survival with isocitrate dehydrogenase (<i>IDH</i>) wild-type glioblastomas is controversial. We investigated whether the duration of use during standard chemoradiation protocol affects overall (OS) patients <i>IDH</i> glioblastoma. <h3>Methods</h3> In this observational single-institution cohort study (2010–2018), inclusion criteria were (1) age ≥18 years; (2) newly diagnosed supratentorial tumor; (3) histomolecular...
Failure in achieving a function-based resection related to the insufficient patient's participation is drawback of awake surgery.To assess preoperative parameters predicting risk patient intraoperative cooperation leading arrest resection.Observational, retrospective, multicentric cohort analysis enrolling 384 (experimental dataset) and 100 (external validation surgeries.In experimental data set, an occurred 20/384 patients (5.2%), surgery failure 3/384 (ie, no resection, 0.8%), precluded...
Tumor-related epilepsy is a well-known symptom of glioblastoma. However, the particular characteristics epileptic seizures related to glioblastoma,
Although awake resection using intraoperative cortico-subcortical functional brain mapping is the benchmark technique for diffuse gliomas within eloquent areas, it still rarely proposed IDH-wildtype glioblastomas. We have assessed feasibility, safety, and efficacy of Observational single-institution cohort (2012-2018) 453 adult patients harboring supratentorial glioblastomas who benefited from resection, asleep or a biopsy. Case matching (1:1) criteria between group group: gender, age,...
Insular diffuse glioma resection is at risk of vascular injury and postoperative new neurocognitive deficits.To assess safety efficacy surgical management insular gliomas.Observational, retrospective, single-institution cohort analysis (2005-2019) 149 adult patients surgically treated for an glioma: transcortical awake with intraoperative functional mapping (awake subgroup, n = 61), asleep without (asleep 50), stereotactic biopsy (biopsy 38). All cases were histopathologically assessed...
BACKGROUND: Robot-assisted stereotactic biopsy is evolving: 3-dimensional intraoperative imaging tools and new frameless registration systems are spreading. OBJECTIVE: To investigate the accuracy effectiveness of a procedure. METHODS: Observational, retrospective analysis consecutive robot-assisted biopsies using Neurolocate (Renishaw) system O-Arm (Medtronic) performed at single institution in adults (2019-2021) comparison with historical series from same (2006-2016) not nor O-Arm. RESULTS:...
Glioblastomas are among the deadliest human cancers and highly vascularized. Angiogenesis is dynamic during brain development, almost quiescent in adult but reactivated vascular-dependent CNS pathologies, including tumors. The oncofetal axis describes reactivation of fetal programs tumors, its relevance endothelial perivascular cells vasculature glial tumors unexplored. Nucleolin a regulator cell proliferation angiogenesis, roles remain unknown. Here, we studied expression neurovascular unit...
Background: Radiological parameters predicting the postoperative neurological outcome after resection of a spinal meningioma (SM) are poorly studied, with controversial results. Methods: Observational multicenter cohort (2011–2018) adult patients undergoing surgery for SM. Tumor-canal volume ratio (TCR), areas related to cord and tumor occupancy at maximum compression, presence dural tail, calcifications, signs myelopathy, expansion were compared modified McCormick scale (mMCS) preoperative...