A5045972173- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Peripheral Nerve Disorders
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- MRI in cancer diagnosis
- Neurological Complications and Syndromes
- Spine and Intervertebral Disc Pathology
- Nerve Injury and Rehabilitation
- Ultrasound and Hyperthermia Applications
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Cervical and Thoracic Myelopathy
- Neurological disorders and treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Bone Tumor Diagnosis and Treatments
- Nanoplatforms for cancer theranostics
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016-2025
University of Milan
2013-2025
European Institute of Oncology
2018
Johns Hopkins University
2018
Neurological Surgery
2018
Fondazione IRCCS Istituto Nazionale dei Tumori
2018
Istituto Ortopedico Galeazzi
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
University of Virginia
2018
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2013
OBJECTIVE The purpose of this study was to assess the capability contrast-enhanced ultrasound (CEUS) identify residual tumor mass during glioblastoma multiforme (GBM) surgery, increase extent resection. METHODS authors prospectively evaluated 10 patients who underwent surgery for GBM removal with navigated guidance. Navigated B-mode and CEUS were performed prior resection, after complete Areas suspected tumors on studies localized within surgical field samples sent separately...
<b>Purpose:</b> Brain shift and tissue deformation during surgery for intracranial lesions are the main actual limitations of neuro-navigation (NN), which currently relies mainly on preoperative imaging. Ultrasound (US), being a real-time imaging modality, is becoming progressively more widespread neurosurgical procedures, but most neurosurgeons, trained axial computed tomography (CT) magnetic resonance (MRI) slices, lack specific US training have difficulties recognizing anatomic structures...
We have previously shown the usefulness of a new confocal endomicroscopy system (CONVIVO®) in providing quick and reliable method for intraoperative diagnosis ex vivo glioblastoma (GBM). In this study, we aimed to assess CONVIVO® an in-vivo setting, focusing on its capability explore presence residual tumor at resection margins Central Nervous System (CNS) tumors. consecutively enrolled patients submitted fluorescein-guided CNS-tumor removal (May 2020 December 2022). was used obtain images...
Contrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization flow distribution patterns different organs tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, thorough characterization cerebral glioma had never before.To perform the first using CEUS to possibly achieve an differentiation gliomas.We in off-label setting 69 patients undergoing surgery glioma. An qualitative analysis was...
Introduction: Glioma surgery is aimed at obtaining maximal safe tumor resection while preserving or improving patient's neurological status. For this reason, there growing interest for intra-operative imaging in neuro-oncological surgery. Intra-operative ultrasound (ioUS) provides the surgeon with real-time, anatomical and functional information. Despite this, neurosurgery ioUS mainly relies only on gray-scale brightness mode (B-mode). Many other modalities, such as Fusion Imaging...
Objective: Sodium fluorescein, a green, water soluble dye, is used as neurosurgical fluorescent tracer thanks to its property accumulate in cerebral regions of blood-brain barrier (BBB) disruption. The authors report the preliminary results prospective observational study regarding use fluorescein-guided technique for resection suspected malignant neoplasms central nervous system (CNS), contrast enhancing at preoperative magnetic resonance imaging (MRI), using dedicated filter on surgical...
Sonoelastography is an ultrasound imaging technique able to assess mechanical properties of tissues. Strain elastography (SE) a qualitative sonoelastographic modality with wide range clinical applications, but its use in brain tumor surgery has been so far very limited.To describe the first large-scale implementation SE oncological neurosurgery for lesions discrimination and characterization.We analyzed retrospective data from 64 patients aiming at (i) evaluating stiffness lesion surrounding...
OBJECTIVE Indocyanine green videoangiography (ICG-VA) is an intraoperative technique used to highlight vessels in neurovascular surgery. Its application the study of vascular pathophysiology CNS tumors and its role their surgical management are still rather limited. A recent innovation ICG-VA (i.e., FLOW 800 algorithm integrated microscope) allows a semiquantitative evaluation cerebral blood flow. The aim this was evaluate for first time systematic analysis during removal tumors. METHODS...
Confocal laser endomicroscopy (CLE) allowing intraoperative near real-time high-resolution cellular visualization is a promising method in neurosurgery. We prospectively tested the accuracy of new-designed miniatured CLE (CONVIVO® system) giving an first-diagnosis during glioblastoma removal.Between January and May 2018, 15 patients with newly diagnosed underwent fluorescein-guided surgery. Two biopsies from both tumor central core margins were harvested, dividing each sample into two...
OBJECTIVE This study investigated whether the selection of different dural substitutes and distinct repair techniques correlates with incidence rate postoperative CSF leak in a mixed population adults children Chiari type I malformation (CM-I) who underwent posterior fossa decompression enlargement duraplasty (PFDD) as first surgical approach. METHODS A retrospective analysis was conducted on all patients admitted to authors’ institution between 2006 2023 for PFDD treat syringomyelia and/or...
OBJECTIVE The best management of veins encountered during the neurosurgical approach is still a matter debate. Even if venous sacrifice were to lead devastating consequences, under certain circumstances, it might prove be desirable, enlarging surgical field or increasing extent resection in tumor surgery. In this study, authors present large series patients with vascular oncological entities, which they used indocyanine green videoangiography (ICG-VA) FLOW 800 analysis study patient-specific...
Despite the increasing popularity of flow diverters (FDs) as an endovascular option for intracranial aneurysms, treatment complex aneurysms still represents a challenge. Combined strategies using flow-preservation bypass could be considered in selected cases. In this study, we retrospectively reviewed our series patients with submitted to bypass. From January 2015 May 2022, 23 were selected. We identified 11 cases (47.8%) MCA, 6 (26.1%) ACA and ICA aneurysms. The mean maximal diameter was...
Hemangioblastomas are benign, highly vascularized intramedullary lesions that may also extend into the intradural space. Surgery represents standard therapy, with goal of obtaining complete resection even at risk neurological morbidity. MRI is gold for diagnosis and assessment tumors. Nevertheless, sometimes not accurately differentiate between different types tumors, in particular if they associated syringes or intra- peritumoral cysts. This could subsequently affect surgical strategies....