A5068333772- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- Trigeminal Neuralgia and Treatments
- Vascular Malformations Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Neurofibromatosis and Schwannoma Cases
- Surgical Simulation and Training
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neurosurgical Procedures and Complications
- Scoliosis diagnosis and treatment
- Pain Mechanisms and Treatments
- Medical Imaging and Analysis
- Global Health and Surgery
- Brain Metastases and Treatment
- Facial Trauma and Fracture Management
- Advanced Neuroimaging Techniques and Applications
- Anatomy and Medical Technology
- Advanced MRI Techniques and Applications
IRCCS Humanitas Research Hospital
2017-2025
Humanitas University
2017-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2022
Neurology, Inc
2020
Fondazione IRCCS Istituto Neurologico Carlo Besta
2018
University of Milan
2017
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2016
Queen Mary University of London
2012
OBJECTIVE Neurosurgical training is usually based on traditional sources of education, such as papers, books, direct surgical experience, and cadaveric hands-on courses. In low-middle income countries, standard education programs are often unavailable, mainly owing to the lack human economic resources. Introducing digital platforms in these settings could be an alternative solution for bridging gap between Western poor countries neurosurgical knowledge. METHODS The authors identified from...
BACKGROUND AND OBJECTIVES: Understanding and managing seizure activity is crucial in neuro-oncology, especially for highly epileptogenic lesions like isocitrate dehydrogenase (IDH)-mutant gliomas. Advanced MRI techniques such as diffusion tensor imaging (DTI) neurite orientation dispersion density (NODDI) have been used to describe microstructural changes associated with epilepsy. However, their role tumor-related epilepsy (TRE) remains unclear. This study aims investigate the of DTI NODDI...
Background/Objectives: Lumbopelvic fixation (LPF) is essential for stabilizing the lumbosacral junction (LSJ) in cases of trauma, tumors, and other pathologies. While minimally invasive percutaneous techniques are preferred when feasible, open LPF remains necessary direct sacral access required. This study describes a modified technique designed to minimize invasiveness while maintaining effective stabilization. Methods: We present case metastasis requiring LPF. The surgical involves linear...
Purpose: To evaluate the role of tumor invasiveness profile in a homogeneous cohort patients with newly diagnosed GBM (2021 WHO) that underwent SUPR by RANO criteria, and to analyze its impact on survival outcomes. Methods: Patients diagnosed, histologically confirmed glial tumors featuring contrast-enhancing lesions, who surgery at our institution between January 2007 2024, were retrospectively reviewed. Preoperative total volume (T-TV), (CE), infiltrative FLAIR (FLAIR-TV) calculated cubic...
OBJECTIVE Indocyanine green videoangiography (ICG-VA) is an intraoperative technique used to highlight vessels in neurovascular surgery. Its application the study of vascular pathophysiology CNS tumors and its role their surgical management are still rather limited. A recent innovation ICG-VA (i.e., FLOW 800 algorithm integrated microscope) allows a semiquantitative evaluation cerebral blood flow. The aim this was evaluate for first time systematic analysis during removal tumors. METHODS...
OBJECTIVE The best management of veins encountered during the neurosurgical approach is still a matter debate. Even if venous sacrifice were to lead devastating consequences, under certain circumstances, it might prove be desirable, enlarging surgical field or increasing extent resection in tumor surgery. In this study, authors present large series patients with vascular oncological entities, which they used indocyanine green videoangiography (ICG-VA) FLOW 800 analysis study patient-specific...
Acromegaly is commonly complicated by arthropathy and skeletal fragility with high risk of vertebral fractures (VFs).This study aimed to assess whether VFs may be associated sagittal spine deformities, arthropathy, impaired quality life (QoL), pain, disability.Thirty-eight patients acromegaly (median age: 55 years, 20 males) 38 matched control subjects were evaluated a low-dose coronal planes, X-ray imaging system (EOS®-2D/3D) for morphometric VFs, radiological signs deformities (Cobb...
Objective: The study aimed at evaluating the efficacy and ability of D-wave monitoring combined with somatosensory evoked potentials (SSEPs) motor (MEPs) to predict functional outcomes in intramedullary spinal cord tumor (IMSCT) surgery. Methods: Between December 2011 2020, all patients harboring IMSCT who underwent surgery our institution were prospectively collected a surgical registry retrospectively analyzed. Patient charts histological reports multimodal IONM included SSEPs, MEPs,...
Polycomb group proteins are essential regulators of stem cell function during embryonic development and in adult tissue homeostasis. Bmi1, a key component the Repressive Complex 1, is highly expressed undifferentiated neural cells (NSC) as well several human cancers including high-grade gliomas--highly aggressive brain tumors. Using conditional gene activation approach mice, we show that overexpression Bmi1 induces repressive epigenetic regulation promoter Survivin, well-characterized...
The operative microscope (OM) represents, to date, the standard for neurosurgical procedures. However, new technologies have been proposed during latest years overcome its limitations, from high-quality exoscopes complex robotised visualisation systems. We report our preliminary experience with a novel digital microscope, BHS RoboticScope (RS), minimally invasive spinal surgery.We employed RS in five consecutive patients who underwent bilateral lumbar spine decompression through monolateral...
Cranioplasty is a surgical intervention aiming to re-establish the integrity of skull defects. Autologous bone and different heterologous materials are used for this purpose, with various reported related complications. The aim study was evaluate complication rate in multicentric cohort patients underwent porous hydroxyapatite (PHA) cranioplasty implantation assess validity company post-market clinical analysis.Authors analyzed company-based register 6279 PHA implanted all over world. In...
OBJECTIVE Anaplastic gliomas (AGs) are an extremely heterogeneous group of primary brain tumors. More recently, new discoveries have indicated that isocitrate dehydrogenase (IDH) mutation status is the most important parameter predicting survival. The aim present analysis was to identify prognostic factors, other than IDH status, eventually impact METHODS Patients with available clinical, imaging, and molecular profile data who were amenable resection evaluated. extent (EOR) defined as...