A5003225683- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Cancer Genomics and Diagnostics
- Epilepsy research and treatment
- Mathematical Biology Tumor Growth
- Medical Imaging Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- Advanced MRI Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Trigeminal Neuralgia and Treatments
- CAR-T cell therapy research
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Reconstructive Surgery and Microvascular Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Diversity and Career in Medicine
- Medical Malpractice and Liability Issues
- Migraine and Headache Studies
- Motivation and Self-Concept in Sports
Humanitas University
2021-2025
IRCCS Humanitas Research Hospital
2019-2025
University of Milan
2019
Fondazione IRCCS Istituto Neurologico Carlo Besta
2018-2019
Abstract Purpose: Current glioma diagnostic guidelines call for molecular profiling to stratify patients into prognostic and treatment subgroups. In case the tumor tissue is inaccessible, cerebrospinal fluid (CSF) has been proposed as a reliable DNA source liquid biopsy. We prospectively investigated use of CSF characterization newly diagnosed gliomas. Experimental Design: recruited two cohorts with glioma, one (n = 45) providing collected in proximity tumor, other 39) by lumbar puncture...
Abstract Background PET with radiolabeled amino acids is used in the preoperative evaluation of patients glial neoplasms. This study aimed to assess role [11C]methionine (MET) assessing molecular features, tumor extent, and prognosis newly diagnosed lower-grade gliomas (LGGs) surgically treated. Methods One hundred fifty-three a new diagnosis grade 2/3 glioma who underwent surgery at our Institution were imaged preoperatively using [11C]MET PET/CT retrospectively included. images...
Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor, bearing a survival estimate below 10% at five years, despite standard chemoradiation treatment. At recurrence, systemic treatment options are limited of care not well defined, with inclusion in clinical trials being highly encouraged. So far, use immunotherapeutic strategies GBM has proved to significantly improve patients’ prognosis newly diagnosed GBM, nor recurrent setting. Probably this do unique immune environment...
BACKGROUND AND OBJECTIVES: Understanding and managing seizure activity is crucial in neuro-oncology, especially for highly epileptogenic lesions like isocitrate dehydrogenase (IDH)-mutant gliomas. Advanced MRI techniques such as diffusion tensor imaging (DTI) neurite orientation dispersion density (NODDI) have been used to describe microstructural changes associated with epilepsy. However, their role tumor-related epilepsy (TRE) remains unclear. This study aims investigate the of DTI NODDI...
Purpose: To evaluate the role of tumor invasiveness profile in a homogeneous cohort patients with newly diagnosed GBM (2021 WHO) that underwent SUPR by RANO criteria, and to analyze its impact on survival outcomes. Methods: Patients diagnosed, histologically confirmed glial tumors featuring contrast-enhancing lesions, who surgery at our institution between January 2007 2024, were retrospectively reviewed. Preoperative total volume (T-TV), (CE), infiltrative FLAIR (FLAIR-TV) calculated cubic...
Abstract Background Differentiating radionecrosis from neoplastic progression after stereotactic radiosurgery (SRS) for brain metastases is a diagnostic challenge. Previous studies have often been limited by datasets lacking histologically confirmed diagnoses. This study aimed to develop automated models distinguishing disease on MRI, utilizing cases with definitive histopathological confirmation. Methods multi-center retrospective included patients who underwent surgical resection suspected...
OBJECTIVE Surgery is the mainstay of treatment for low-grade glioma (LGG)–related epilepsy. However, goal achieving both oncological radical resection and seizure freedom can be challenging. PET with [ 11 C]methionine (MET) has been recently introduced in clinical practice management patients LGGs, not only to monitor response treatments, but also as a preoperative tool define metabolic tumor extent predict grading, type, prognosis. Still, its role defining tumor-related epilepsy...
The operative microscope (OM) represents, to date, the standard for neurosurgical procedures. However, new technologies have been proposed during latest years overcome its limitations, from high-quality exoscopes complex robotised visualisation systems. We report our preliminary experience with a novel digital microscope, BHS RoboticScope (RS), minimally invasive spinal surgery.We employed RS in five consecutive patients who underwent bilateral lumbar spine decompression through monolateral...
We evaluate the feasibility of a single-stage posterior corpectomy and circumferential arthrodesis with aid spinal navigation for treatment traumatic thoracolumbar burst fractures. This was single-center, retrospective study. Demographics, clinical, radiologic data 19 patients who underwent surgery at our institution fractures between 2016 2019 were collected. All enrolled in present study by means fixation transpedicular an intraoperative image-guided neuronavigation system. Postoperative...
2065 Background: Glioblastoma (GBM) bears a survival estimate below 10% at 5 years, despite standard chemoradiation treatment. Trials evaluating immune checkpoint blockade (ICB) in gliomas have been disappointing so far, dealing with the unique immunosuppressive tumor microenvironment (TME) of brain. Nevertheless, we clinical evidence ICB efficacy for brain metastases (BrM) immunosensitive tumors. Even if both GBMs and BrM share same organ-specific microenvironment, it is clear that...
Over the past two decades, an increasing body of literature has supported validity and utility 2x2 Achievement Goal Framework (Elliot & McGregor, 2001) often applied in schools but also a sports context. In present study, this model been context particular with sample 96 professional swimmers medium to elite level. For aim, we used Questionnaire for Sport (AGQ-S) (Conroy, Elliot Hofer, 2003), analysed alongside other constructs such as orientation motivational climate sport, self-efficacy...