A5013184511- Cardiac Valve Diseases and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Mechanical Circulatory Support Devices
- Ubiquitin and proteasome pathways
- Lipid metabolism and disorders
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- ATP Synthase and ATPases Research
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Angiogenesis and VEGF in Cancer
- Infective Endocarditis Diagnosis and Management
- Radiomics and Machine Learning in Medical Imaging
- Hippo pathway signaling and YAP/TAZ
- Neurological disorders and treatments
- Connective tissue disorders research
- Restless Legs Syndrome Research
- Fibroblast Growth Factor Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac and Coronary Surgery Techniques
Humanitas University
2025
IRCCS Humanitas Research Hospital
2025
Albert Einstein College of Medicine
2022-2024
Montefiore Medical Center
2023
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, cardiovascular system function; despite these functional overlaps, little is known about Wnt/β-catenin-S1P cross-talk. In the vascular system, both Wnt/β-catenin S1P signals affect vessel maturation, stability, barrier function, but information regarding their potential coordination scant. We report an...
Abstract Background Differentiating radionecrosis from neoplastic progression after stereotactic radiosurgery (SRS) for brain metastases is a diagnostic challenge. Previous studies have often been limited by datasets lacking histologically confirmed diagnoses. This study aimed to develop automated models distinguishing disease on MRI, utilizing cases with definitive histopathological confirmation. Methods multi-center retrospective included patients who underwent surgical resection suspected...
<b>Abstract ID 56626</b> <b>Poster Board 156</b> Vascular remodeling is associated with target organ damage and fatal cardiovascular events. The molecular mechanisms that control vascular are still poorly understood, limiting effective therapeutic approaches. smooth muscle cells (SMCs), in part via activation of the Wnt/β-catenin signaling pathway, contribute importantly to remodeling. β-catenin C-terminal domain required SMCs for artery formation during embryogenesis, but its role adulthood...
Introduction: Vascular remodeling is associated with target organ damage and fatal cardiovascular events. The molecular mechanisms that control vascular are still poorly understood, limiting effective therapeutic approaches. β-catenin C-terminal domain required in smooth muscle cells (SMCs) for artery formation during embryogenesis, but its role adulthood unknown. Therefore, the objective of this study was to define importance SMCs remodeling. Hypothesis: signaling neointima after injury....
Vascular smooth muscle cells (SMCs), in part via activation of the Wnt/β-catenin signaling pathway, contribute importantly to vascular remodeling. While C-terminal domain β-catenin links pathway gene expression, how this and related molecular mechanisms are involved remodeling is unknown. Inhibitors targeting specifically have been developed, but their use obstructive disease not yet justified because gap knowledge. Our group has previously shown that SMCs essential for arterial wall...