A5048278348- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Spinal Fractures and Fixation Techniques
- Fetal and Pediatric Neurological Disorders
- Bone Tumor Diagnosis and Treatments
- Nanoplatforms for cancer theranostics
- Vascular Malformations Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Sinusitis and nasal conditions
- Intracranial Aneurysms: Treatment and Complications
- Teratomas and Epidermoid Cysts
- Advanced MRI Techniques and Applications
- Spinal Dysraphism and Malformations
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Spine and Intervertebral Disc Pathology
- Cerebrovascular and Carotid Artery Diseases
- Vascular Tumors and Angiosarcomas
- Global Health and Surgery
- Radiomics and Machine Learning in Medical Imaging
- Cervical and Thoracic Myelopathy
Ospedale Policlinico San Martino
2024-2025
Fondazione IRCCS Istituto Neurologico Carlo Besta
2014-2023
Istituto delle Scienze Neurologiche di Bologna
2020-2023
University of Bologna
2020-2023
University of Milan
2012-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
New York Hospital Queens
2018
Presbyterian Hospital
2018
NewYork–Presbyterian Hospital
2018
Cornell University
2018
Abstract Purpose: Sodium fluorescein is a dye that, intravenously injected, selectively accumulates in high-grade glioma (HGG) tissue through damaged blood–brain barrier. In this article, the final results of multicentric prospective phase II trial (FLUOGLIO) on fluorescein-guided HGG resection dedicated filter surgical microscope were reported. Methods: Patients with suspected HGGs considered suitable for removal eligible to participate trial. Fluorescein was injected at dose 5 10 mg/kg....
Object Fluorescein, a dye that is widely used as fluorescent tracer, accumulates in cerebral areas where the blood-brain barrier damaged. This quality makes it an ideal for intraoperative visualization of high-grade gliomas (HGGs). The authors report their experience with new fluorescein-guided technique resection HGGs using dedicated filter on surgical microscope. Methods initiated prospective Phase II trial (FLUOGLIO) September 2011 objective evaluating safety surgery and obtaining...
OBJECTIVE Anterior skull base meningiomas are benign lesions that cause neurological symptoms through mass effect on adjacent neurovascular structures. While traditional transcranial approaches have proven to be effective at removing these tumors, minimally invasive involve using an endoscope offer the possibility of reducing brain and nerve retraction, minimizing incision size, speeding patient recovery; however, appropriate case selection results in large series lacking. METHODS The...
OBJECT The Milan Complexity Scale—a new practical grading scale designed to estimate the risk of neurological clinical worsening after performing surgery for tumor removal—is presented. METHODS A retrospective study was conducted on all elective consecutive surgical procedures resection between January 2012 and December 2014 at Second Division Neurosurgery Fondazione IRCCS Istituto Neurologico Carlo Besta Milan. prospective database dedicated reporting complications radiological data...
The endoscopic endonasal approach (EEA) provides a minimally invasive corridor through which the cervicomedullary junction can be decompressed with reduced morbidity rates compared to those classic transoral approaches. limit of EEA is its inferior extent, and preoperative estimation reach vital for determining suitability. aim this study was evaluate actual in surgical series patients develop an accurate reliable predictor that used planning odontoidectomies.The extent surgery determined 6...
BACKGROUND: The endoscopic endonasal approach (EEA) has developed as an emerging surgical corridor to the craniovertebral junction (CVJ). In addition understanding its indications and anatomy, ability predict inferior limit is vital for optimal planning. OBJECTIVE: To develop a method that accurately predicts of EEA on CVJ radiologically compare this with other currently used methods. METHODS: Predissection computerized tomographic scans 9 cadaver heads were delineate novel line, naso-axial...
Surgical treatment of orbital lesions is challenging because complex approaches with a high risk postoperative sequelae are required. Recently, minimally invasive endoscopic through endonasal (EEA) and transpalpebral (ETP) routes have been proposed. The objective this study was to assess outcomes EEA ETP in the authors' series patients lesions.
Despite the increasing popularity of flow diverters (FDs) as an endovascular option for intracranial aneurysms, treatment complex aneurysms still represents a challenge. Combined strategies using flow-preservation bypass could be considered in selected cases. In this study, we retrospectively reviewed our series patients with submitted to bypass. From January 2015 May 2022, 23 were selected. We identified 11 cases (47.8%) MCA, 6 (26.1%) ACA and ICA aneurysms. The mean maximal diameter was...
OBJECTIVE Epidermoid cysts (ECs) commonly extend to involve the ventral cisterns of cranial base. When present, symptoms arise due progressive mass effect on brainstem and adjacent nerves. Historically, a variety open microsurgical approaches have been used for resection ECs in this intricate region. In recent years, endoscopic endonasal approach (EEA) has proposed as an alternative corridor that avoids crossing plane To date, there is paucity data literature regarding safety efficacy EEA...
Surgery of brainstem lesions is increasingly performed despite the fact that surgical indications and techniques continue to be debated. The deep pons, in particular, continues a critical area which specific risks related different strategies examined. With intention bringing new knowledge into this important arena, authors systematically examined results surgeries have been through lateral infratrigeminal transpontine window.Between 1990 2013, 29 consecutive patients underwent surgery...
Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied chordomas. Our aim to investigate chordoma behavior the role of ceramides. Ceramides were extracted evaluated by liquid chromatography mass spectrometry cohort patients with skull chordoma. Clinical data also collected correlated ceramide levels. Linear regression correlation analyses conducted. Analyzing association between...
Abstract Purpose Longstanding overt ventriculomegaly in adults (LOVA) represents a form of chronic adulthood hydrocephalus with symptomatic manifestation late adulthood. Based on the patency aqueduct, two different subcohorts LOVA can be distinguished. Surgical treatments this condition are also debated. Therefore, we analyzed preoperative characteristics and clinical outcome after surgical subgroup patients patent aqueduct. Methods Eighteen aqueduct consecutively treated at our institution...
It is commonly reported that maximizing surgical resection of contrast-enhancing regions in patients with glioblastoma improves overall survival. Efforts to achieve an improved rate have included several tools: among those, the recent widespread fluorophores. Sodium fluorescein unspecific, vascular dye which tends accumulate areas altered blood–brain barrier. In this retrospective analysis prospectively enrolled FLUOCERTUM study, we aimed assess role fluorescein-guided surgery on radicality,...
Thalamic gliomas represent a heterogeneous subset of deep-seated lesions for which surgical removal is advocated, although clear prognostic factors linked to advantages in performance status or overall survival are still lacking. We reviewed our Institutional Cancer Registry, identifying patients who underwent surgery thalamic between 2006 and 2020. Associations possible such as tumor volume, grade, the extent resection (PS), (OS) were evaluated using univariate multivariate analyses. found...