A5000144881- Glioma Diagnosis and Treatment
- Scoliosis diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Spinal Fractures and Fixation Techniques
- Minimally Invasive Surgical Techniques
- Wireless Power Transfer Systems
- Ultrasound Imaging and Elastography
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Spine and Intervertebral Disc Pathology
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
Fondazione IRCCS Istituto Neurologico Carlo Besta
2022-2025
University of Milan
2022-2024
Focused Ultrasound Foundation
2024
Fluorescein-mediated sonodynamic therapy (FL-SDT) is an extremely promising approach for glioma treatment, resulting from the combination of low-intensity focused ultrasound (FUS) with a sonosensitizer. In present study, we evaluated efficacy and immunomodulation SDT fluorescein as sonosensitizer in immunocompetent GL261 mice first time. vitro studies demonstrated that exposure cells to FL-SDT induced immunogenic cell death relevant upregulation MHC class I, CD80 CD86 expression. vivo were...
The blood–brain barrier (BBB) poses a significant challenge to drug delivery the brain. A promising approach involves low-frequency, low-intensity pulsed ultrasound (US) waves combined with intravenously injected microbubbles (MB) temporarily and non-invasively open BBB. However, current technologies cannot easily integrate this procedure US imaging. Passive cavitation detection, tracing harmonic emissions of MB during sonication, has been preferred method for real-time monitoring...