A5011685200- Veterinary Oncology Research
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Cancer Research and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Microbial infections and disease research
- Hematopoietic Stem Cell Transplantation
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Oral and Maxillofacial Pathology
- Neuroendocrine Tumor Research Advances
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Neuroblastoma Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Animal Behavior and Welfare Studies
- Cancer, Hypoxia, and Metabolism
- Veterinary Medicine and Surgery
- Neutropenia and Cancer Infections
- Veterinary Orthopedics and Neurology
- Human-Animal Interaction Studies
- Head and Neck Surgical Oncology
- Hematological disorders and diagnostics
Sydney Hospital
2016
Tufts University
2002-2012
Hematology Oncology Consultants
2009-2011
The University of Sydney
2010
Cornell University
1992-2009
University of Georgia
2006-2009
New York State College of Veterinary Medicine
2009
Dartmouth–Hitchcock Medical Center
2006
Universidade Estadual de Londrina
2005
University of Minnesota
2005
Summary Long-term follow-up information pertaining to 162 dogs with appendicular osteosarcoma treated by amputation alone was collected from 17 veterinary institutions. The majority (72.5%) of died or were euthanatized because problems documented be related metastases. first clinically apparent sites metastasis the lungs (60.8% total), skeleton (5.2%), both (4.6%). A Kaplan-Meier survivorship distribution plotted on basis available survival time data in all dogs. mean and median times...
Paraffin-embedded, formalin-fixed tissue samples from 145 cats with lymphoma were analyzed for cluster of differentiation 3 (CD3, a surface antigen) immunoreactivity, argyrophilic nucleolar organizer region (AgNOR) frequency, and proliferating cell nuclear antigen labeling index (PCNA-LI). This information along signalment, anatomic site, feline leukemia virus (FeLV) status was used to determine the potential these indicators predict response therapy, remission, survival times, characterize...
A retrospective analysis was performed on the case records of 32 dogs with Stage I or II splenic hemangiosarcoma that were treated by splenectomy alone and survived seven-day postoperative period. Median survival time for these cases 86 days (mean, 116 days; range, 14 to 470 days), one-year rate estimated be 6.25%. Survival not influenced signalment, presenting signs, stage disease, clinicopathological findings. The data provides a basis from which evaluate adjuvant chemotherapy is confined...
To evaluate response rate and duration of malignant melanomas in dogs treated with carboplatin.Retrospective study.27 client-owned spontaneously occurring measurable melanomas.Records carboplatin from October 1989 to June 2000 were reviewed. Carboplatin was administered IV at doses 300 or 350 mg/m2 body surface area. Response treatment evidence drug toxicity determined.Response could be evaluated 25 dogs. Of those, overall 28%. One dog had a complete response, 6 (24%) partial (> 50%...
To evaluate response to chemotherapy in cats with alimentary lymphoma and determine factors associated survival time.Retrospective case series.28 that underwent chemotherapy.In all cats, the diagnosis had been established by means of cytologic or histologic examination ultrasound-guided aspirates biopsy specimens (18 cats), surgically obtained (7 endoscopically (3 cats). Clinical signs included anorexia, weight loss, vomiting, diarrhea. Twenty-seven were treated vincristine sulfate,...
Abstract Objective —To characterize the signalment, clinical signs, biological behavior, and response to treatment of carcinoma apocrine glands anal sac in dogs. Design —Retrospective study. Animals —113 dogs with histologically confirmed sac. Procedure —Data on staging were reviewed analyzed along modality for potential association survival time. Results —Sex distribution was approximately equal (54% female, 46% male). One hundred four underwent consisting surgery, radiation therapy,...
The efficacy and toxicity of CCNU (1-[2-chloroethyl]3-cyclohexyl-1-nitrosourea) were evaluated in 23 dogs with measurable mast cell tumors (MCT). Twenty-two had cutaneous MCT 1 dog an intranasal Nineteen (83%) biopsy their original mass performed 4 (17%) aspiration cytology masses. Of the 19 histologically graded, (5%) neoplasm was classified as grade I, 10 (53%) II, remaining 8 (42%) III. Dogs treated at a dosage 90 mg/m2 body surface area every 3 weeks. Response could be dogs. Eight...
Case information and histologic slides for 688 admissions of feline tissues from 12 veterinary institutions were assembled reviewed to determine obtained by biopsy or necropsy, age sex cat, tumor topography, leukemia viral antigen status, frequency mitoses, diagnosis, presence necrosis, degree sclerosis. Histologic sections examined place the lesions in one diagnostic categories National Cancer Institute working formulation (NCI WF) lymphomas lymphoid leukemia. Correlations between various...
Low-grade alimentary lymphoma (LGAL) was diagnosed by histological and immunohistochemical evaluation of full-thickness biopsies from multiple regions the gastrointestinal tract collected during exploratory laparotomy in 17 cats. The most common clinical signs were weight loss ( n=17) vomiting and/or diarrhoea n=15). Clinical chronic 11 cases. Abdominal palpation abnormal 12 cats, including diffuse intestinal thickening n=8), an abdominal mass due to mesenteric lymph node enlargement n=5) a...
There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of number treatment options, the increased financial costs associated with treatment, emotional stress experienced by owners association disease its treatment. Numerous studies have evaluated potential neoplastic diseases, but there are no established guidelines or standards conduct reporting medicine. This lack standardization has made evaluation comparison difficult. Most...
Forty‐three dogs with lymphoma that had relapsed or failed to achieve complete remission previous chemotherapy were treated lomustine (1‐(2‐chloroethyl)‐3‐cyclohexyl‐l‐nitrosourea [CCNU]) at a dosage of 90–100 mg/m 2 body surface area PO every 3 weeks. Durable partial responses occurred in 11 for median 86 days. The acutely dose‐limiting toxicosis was neutropenia 7 days after administration, resulting recommended 90 . Cumulative thrombocy‐topenia receiving continued CCNU treatment, and dose...
One hundred and fifty dogs with histopathologically confirmed intestinal disease were evaluated retrospectively. Sixty-one had enteritis 89 neoplasia. Ultrasonographic findings including the thickness distribution of lesion, integrity wall layering, regional lymph node thickness, location segment involved, motility evaluated. Dogs tumor (1.5 cm) significantly greater than NSE lesions (0.6 cm; p < 0.001). Ninety-nine percent loss layering while 88% normal or altered (p more likely to have...
The efficacy and toxicity of CCNU (1‐[2‐chloroethyl]3‐cyclohexyl‐l‐nitrosurea) were evaluated in 23 dogs with measurable mast cell tumors (MCT). Twenty‐two had cutaneous MCT 1 dog an intranasal Nineteen (83%) biopsy their original mass performed 4 (17%) aspiration cytology masses. Of the 19 histologically graded, (5%) neoplasm was classified as grade I, 10 (53%) II, remaining 8 (42%) III. Dogs treated at a dosage 90 mg/m 2 body surface area every 3 weeks. Response could be dogs. Eight...
Forty-three dogs with lymphoma that had relapsed or failed to achieve complete remission previous chemotherapy were treated lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea [CCNU]) at a dosage of 90-100 mg/m2 body surface area p.o. every 3 weeks. Durable partial responses occurred in 11 for median 86 days. The acutely dose-limiting toxicosis was neutropenia 7 days after administration, resulting recommended 90 mg/m2. Cumulative thrombocytopenia receiving continued CCNU treatment, and...
Oral squamous cell carcinoma (SCC) is a common malignancy in cats, but little currently known about its etiology. We examined the relationship between risk of oral SCC and factors such as environmental tobacco smoke, flea control products, diet 36 domestic cats with histologically confirmed 112 renal disease presented to large veterinary referral hospital 1994 2000. Questionnaires were mailed owners all study assess demographic characteristics, lifestyle factors, level chemical exposures 2...
Eighty-two dogs with lymphoma received a single 15-week course of chemotherapy, after which treatment was ceased until relapse. Fifty-six (68%) achieved complete remission for median 1st duration 20 weeks. Forty-eight relapsed, 30 repeated the induction cycle. In 22 these dogs, had been short, and they maintenance chemotherapy; other 8 2 or 3 cycles chemotherapy. Second rate 87% (26 dogs). Overall disease control 38 that remained on protocol 44 weeks, not markedly shorter than treated...
Ninety-eight dogs with lymphoma treated a 5-drug combination chemotherapy regimen (vincristine, L-asparaginase, cyclophosphamide, doxorubicin, prednisone [VELCAP-L]) were evaluated for pretreatment characteristics predictive response and remission duration. The complete rate was 69%, median duration of 55 weeks. Dogs advanced stage disease, constitutional signs, that older, dyspneic less likely to achieve remission. Once in remission, small without thrombocytopenia have longer Toxicoses...
Summary One hundred twenty-six dogs with histologically confirmed, measurable malignant tumors were evaluated in a prospective study to determine the response antineoplastic drug mitoxantrone. Ninety-five had been refractory one or more treatment modalities (surgery, n = 57; chemotherapy other than mitoxantrone, 37; radiation, 4; whole body hyperthermia, 1). The extent of neoplastic disease was determined immediately before each dose mitoxantrone administered (1 10 doses, 2.5 5 mg/m 2...
Background: Chemotherapy for multicentric canine lymphoma has favorable results. The gastrointestinal (GI) tract is the most common extranodal site of lymphoma, but there have been no prospective studies to determine outcome when dogs with GI are treated chemotherapy. Hypothesis: Treatment a multiagent chemotherapy protocol associated poor in lymphoma. Animals: Eighteen histologically confirmed Methods: Prospective clinical trial which were 20‐week combination consisting induction and...
Background: Histiocytic sarcoma (HS) is an aggressive neoplasm in dogs, and most instances, the disease localized, but not amenable to surgical removal, or disseminated. Affected patients usually die within 6 months. There have been no prospective studies determine efficacy of single-agent chemotherapy dogs with HS. Hypothesis: Single-agent CCNU [1-(2-chloroethyl)3-cyclohexyl-1-nitrosourea; lomustine] has antitumor activity against HS dogs. Animals: Twenty-one histologically confirmed,...
Thirty‐eight cats with lymphoma were treated vincristine, cyclophosphamide, and prednisone (COP). They randomized at entry to receive maintenance chemotherapy consisting of either single‐agent doxorubicin or continued COP therapy, starting on week 4 treatment continuing for 6 months until relapse. Eighteen achieved complete clinical remission after induction chemotherapy. The median duration 11 was 83 days, which significantly shorter than 7 that received (281 days). Thus, should be...
A chemotherapeutic protocol using cyclophosphamide, vincristine, prednisone, doxorubicin, and L-asparaginase (ACOPA II) was evaluated in dogs with lymphoma. The response rate for 68 treated ACOPA II (complete remission [CR] 65%, partial [PR] 10%) lower than that 41 a related previously I; CR 76%, PR 12%). Initial treatment doxorubicin prednisone did not decrease the prevalence or severity of toxicity during induction. mortality induction 22%. median duration 9 months, 40% still at 1 year 21%...
Six dogs with a median age of 7 years (range = 5–14 years) were presented for signs referable to thoracic or abdominal effusion associated neoplasia the body cavities. Intracavitary cisplatin was administered at 50 mg/m 2 every 4 weeks 2.5 treatments (mean 3, range 1–6). Three pleural mesothelioma had complete resolution 289, 129, and > 306 days without evidence tumor growth. Resolution occurred after one treatment in two dog. In three carcinomatosis unknown origin, responses seen 255 807...