A5007522469- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Microbial infections and disease research
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Oral and Maxillofacial Pathology
- Cutaneous Melanoma Detection and Management
- Virus-based gene therapy research
- Animal Virus Infections Studies
- AI in cancer detection
- Tumors and Oncological Cases
- Mast cells and histamine
- Platelet Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Bird parasitology and diseases
- Biomedical Text Mining and Ontologies
- Growth Hormone and Insulin-like Growth Factors
- Veterinary Equine Medical Research
- Viral gastroenteritis research and epidemiology
- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Viral Infections and Vectors
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
Michigan State University
2013-2023
University of Bern
2022
University of Veterinary Medicine Vienna
2022
North Carolina State University
2022
Technische Hochschule Ingolstadt
2022
Roche (Switzerland)
2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022
Ludwig-Maximilians-Universität München
2022
IDEXX Laboratories (Germany)
2022
Idiap Research Institute
2022
Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists institutional modifications make value highly questionable. To evaluate consistency microscopic among significance Patnaik system, 95 MCTs from dogs were graded in a blinded study 28 16 institutions. Concordance was 75% diagnosis grade 3 less than 64% 1 2 MCTs. improve concordance to...
Melanoma represents a significant malignancy in humans and dogs. Different from genetically engineered models, sporadic canine melanocytic neoplasms share several characteristics with human disease that could make dogs more relevant preclinical model. Canine melanomas rarely arise sun-exposed sites. Most occur the oral cavity, subset having intra-epithelial malignant melanocytes mimicking situ component of mucosal melanoma. The spectrum neoplasia includes benign lesions some analogy to nevi,...
Differentiating between inflammatory bowel disease (IBD) and small intestinal lymphoma in cats is often difficult, especially when only endoscopic biopsy specimens are available for evaluation. However, a correct diagnosis imperative proper treatment prognosis. A retrospective study was performed using surgical from 63 with history of chronic diarrhea or vomiting weight loss. inflammation based on microscopic examination hematoxylin eosin (HE)–stained sections alone, HE-stained plus results...
Oral melanoma is a common canine cancer with historically poor prognosis. Recent evidence suggests that subset of cases may have more favorable outcome, defined as long-term survival in the absence intervention other than initial surgery. Traditional histological parameters had prognostic significance some studies but not others, potentially due to interobserver variation. We evaluated utility Ki67 immunohistochemistry group 79 oral melanomas using technique easily applied veterinary...
Oral malignant melanoma (OMM) in the dog is often locally aggressive with a high metastatic potential and there are few treatment options that have been demonstrated to improve outcome of this disease. The purpose study was determine whether adjunctive Oncept vaccine affected dogs OMM had achieved loco-regional cancer control. Medical records from 45 presented Animal Cancer Imaging Center were reviewed, including 30 stage II III Dogs received did not achieve greater progression-free...
Definitive diagnosis of canine oral melanocytic neoplasms is often difficult because variability in pigmentation and cellular pleomorphism. These can resemble carcinomas, sarcomas, round cell neoplasms, which differ prognosis treatment. A variety immunohistochemical antibodies have been used for humans dogs; however, sensitivity specificity many markers not determined amelanotic dogs. The authors investigated a comprehensive panel 49 neoplasms—namely, Melan-A, PNL2, HMB-45, microphthalmia...
Neoplastic diseases are typically diagnosed by biopsy and histopathological evaluation. The pathology report is key in determining prognosis, therapeutic decisions, overall case management therefore requires diagnostic accuracy, completeness, clarity. Successful relies on collaboration between clinical veterinarians, oncologists, pathologists. To date there has been no standardized approach or guideline for the submission, trimming, margin evaluation, reporting of neoplastic specimens...
There is an increasing need for more accurate prognostic and predictive markers in veterinary oncology because of number treatment options, the increased financial costs associated with treatment, emotional stress experienced by owners association disease its treatment. Numerous studies have evaluated potential neoplastic diseases, but there are no established guidelines or standards conduct reporting medicine. This lack standardization has made evaluation comparison difficult. Most...
Mitotic count (MC) is an important element for grading canine cutaneous mast cell tumors (ccMCTs) and determined in 10 consecutive high-power fields with the highest mitotic activity. However, there variability area selection between pathologists. In this study, MC distribution effect of on were analyzed ccMCTs. Two pathologists independently annotated all figures whole-slide images 28 ccMCTs (ground truth). Automated image analysis was used to examine ground truth throughout tumor section...
Standardization of tumor assessment lays the foundation for validation grading systems, permits reproducibility oncologic studies among investigators, and increases confidence in significance study results. Currently, there is minimal methodological standardization assessing tumors veterinary medicine, with few attempts to validate published protocols schemes. The current article address these shortcomings by providing standard guidelines parameters evaluating specific types. More detailed...
The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intraobserver discrepancies due to difficulties in selecting the region interest (MC-ROI) identifying or classifying figures (MFs). Recent progress field artificial intelligence allowed development high-performance algorithms that may improve standardization MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists ensure...
Labrador Retrievers with elevated hepatic copper levels have been reported; however, it is unclear whether primary copper-associated hepatitis occurs in this breed. The objective of study was to determine could be identified Labradors by reviewing cases from the Diagnostic Center for Population and Animal Health, Michigan State University. Sixteen (3 male, 12 female, 1 undetermined sex) between 4 11 years old, had multifocal coalescing, centrilobular characterized macrophages abundant...
Background Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defects copper metabolism have exacerbated by increased environmental exposure. However, no broad epidemiological investigations performed to investigate quantitative hepatic concentrations ([Cu] H ) over time both dogs are (predisposed breed [PB]), not (non‐predisposed [NPB]), considered at‐risk for CAH. Objectives To [Cu] explore temporal, demographic, histologic...
Background Copper‐associated hepatitis ( CAH ) has been well described in Labrador Retrievers. However, the association of with proximal renal tubular dysfunction this breed not characterized. Objectives To report clinical features, hepatic and histopathologic findings, tissue copper concentrations, outcome Labradors disease. Animals Nine Retrievers glucosuria biopsy‐confirmed . Methods Clinical, clinicopathologic, light microscopic findings were retrospectively reviewed. Rhodanine staining...
Malignant melanomas are aggressive neoplasms that relatively common in penguins compared to other avian species. In this study, the clinical and pathologic characteristics of melanocytic five macaroni (Eudyptes chrysolophus), three rock hopper chrysocome), two Humboldt (Spheniscus humboldti) described. Tumors most commonly occurred skin foot or hock, were seen subcutaneous muscle, especially near beak/oral cavity. Gross lesions usually heavily pigmented, becoming raised ulcerated over time....
Cushing's syndrome in humans shares many similarities with its counterpart dogs terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. In both species, treatment pituitary- adrenal-dependent disease is met limitations. ATR-101, a selective inhibitor ACAT1 (acyl coenzyme A:cholesterol acyltransferase 1), novel small molecule therapeutic currently development for the adrenocortical carcinoma, congenital hyperplasia, humans. Previous studies healthy...
Abstract Background Hepatocellular carcinoma (HCC) is the most common primary liver tumor in dogs. Abnormalities hepatic copper, iron, zinc, and selenium concentrations increase risk for HCC development other species, but trace mineral have not been evaluated dogs with HCC. Objectives To investigate Animals Archived specimens from 85 control Methods Retrospective case‐control study. A histopathology database was searched to identify (test population) an age‐matched population. Demographic...
Canine oral malignant melanomas (OMMs) exhibit a variety of morphologic phenotypes, including spindloid variant. The microscopic diagnosis OMMs is based on junctional activity and/or the presence melanin pigment. In absence these features, are difficult to differentiate from soft tissue sarcomas (STS). An antibody cocktail (MDX) that includes Melan-A, PNL2, and tyrosinase-related proteins 1 2 (TRP-1 TRP-2) current gold standard for identifying amelanotic by immunohistochemistry (IHC)....
Nine juvenile ferrets (Mustela putorius furo) with a history of diarrhea were severely dehydrated and had distended abdomens thin-walled small intestines that contained gas fluid. Histologically, exhibited acute superficial atrophic enteritis. Transmission electron microscopy the intestine showed rotavirus-like particles within apical vacuoles. Reverse transcription polymerase chain reaction (RT-PCR) was negative for group A rotavirus. C rotavirus-specific RT-PCR assay developed using...
Abstract Background Based on results of earlier studies, brain, heart and kidney are most commonly used for West Nile virus (WNV) detection in avian species. Both monoclonal polyclonal antibodies have been the immunohistochemical diagnosis WNV these Thus far, no studies performed to compare sensitivity specificity detecting American crows ( Corvus brachyrhynchos ). Our objectives were determine 1) comparative sensitivities (IHC) infection free-ranging crows, 2) which organ(s) is/are suitable...
Immunolabeling for the critical lymphocyte survival factor, Bcl-2, of intestinal biopsies from cats with histologic evidence inflammatory bowel disease (IBD) or gastrointestinal (GI) lymphoma was evaluated to determine if expression differed significantly between these two processes. Bcl-2 performed on small endoscopic full thickness biopsy sections 55 cats. Diagnosis IBD, T-cell B-cell established previously. The percentage infiltrating lymphocytes that were positively labeled subjectively...