A5060089335- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Virus-based gene therapy research
- Higher Education Governance and Development
- Microbial infections and disease research
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Reproductive Physiology in Livestock
- Acute Lymphoblastic Leukemia research
- Folate and B Vitamins Research
- Cancer and Skin Lesions
- Veterinary Equine Medical Research
- Pituitary Gland Disorders and Treatments
- Ruminant Nutrition and Digestive Physiology
- Cancer Research and Treatments
- Viral gastroenteritis research and epidemiology
- Tumors and Oncological Cases
- Animal Disease Management and Epidemiology
- Sarcoma Diagnosis and Treatment
- Hormonal and reproductive studies
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Higher Education Practises and Engagement
- Hedgehog Signaling Pathway Studies
- Herpesvirus Infections and Treatments
Purdue University West Lafayette
2015-2024
OhioHealth
2024
NHS Lothian
2023
University of Nevada, Reno
2023
Edith Cowan University
2022
University of California, Davis
2021
Center for Cancer Research
2018-2020
Janssen (United States)
2020
Minneapolis VA Health Care System
2020
Newcastle upon Tyne Hospital
2018
Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists institutional modifications make value highly questionable. To evaluate consistency microscopic among significance Patnaik system, 95 MCTs from dogs were graded in a blinded study 28 16 institutions. Concordance was 75% diagnosis grade 3 less than 64% 1 2 MCTs. improve concordance to...
A study was carried out to test the accuracy and consistency of veterinary pathologists, not specialists in hematopathology, applying World Health Organization (WHO) system classification canine lymphomas. This represents an initiative ACVP Oncology Committee, has been endorsed by Small Animal Veterinary Association (WASVA). Tissue biopsies from cases lymphoma were received oncologists, a pathologists given only signalment on 300 cases. Twenty reviewed these with each required choose...
A total of 340 cases cutaneous neoplasia were diagnosed in 3,564 cats that examined by biopsy or necropsy during a 41-month period from January 1, 1986 through May 31, 1989. Eighteen types tumor occurred, but four comprised 77% the cases. These basal cell tumor, 89 (26%, mean age 10.3); mast 72 (21%, 8.6); squamous carcinoma, 52 (15%, 11.6); and fibrosarcoma, 50 10.2). For each these tumors, peak number occurred older than 10 years. Mast was only younger 1 year. The head most common site for...
Immunohistochemistry (IHC) is routinely used in diagnostic pathology to detect infectious agents, immunophenotype neoplastic cells, and prognosticate diseases. Formalin fixation considered a limiting factor for IHC because formalin can cross-link antigens mask epitopes. Prolonged presumed result decreased antigen detection; however, this effect has only been evaluated with few antibodies. The goal of study was evaluate the prolonged on immunohistochemical detection 61 different antigens....
Multiple myeloma oncogene 1/interferon regulatory factor 4 (MUM1/IRF4) is involved in lymphoid cell differentiation, particularly the production of plasma cells. We examined immunoreactivity mouse monoclonal antibody Mum-1p to MUM1/IRF4 and compared it with expression CD79a CD20 109 plasmacytomas 107 dogs. Tissues had been fixed formalin embedded paraffin. One hundred one (93.5%) tumors were positive for MUM1/IRF4. The staining was nuclear weak cytoplasmic reaction. Fifty-nine 105 (56.2%)...
Neoplastic diseases are typically diagnosed by biopsy and histopathological evaluation. The pathology report is key in determining prognosis, therapeutic decisions, overall case management therefore requires diagnostic accuracy, completeness, clarity. Successful relies on collaboration between clinical veterinarians, oncologists, pathologists. To date there has been no standardized approach or guideline for the submission, trimming, margin evaluation, reporting of neoplastic specimens...
Twenty‐five dogs with naturally occurring mast cell tumors were treated daily oral prednisone (1 mg/kg) for 28 days. Five (20%) had reduction in tumor volume and considered responders. Four of these underwent partial remission one complete remission. Survival times the five responders 3, 5, 6, 7.5, greater than months, respectively. We therefore conclude that is effective some canine tumors. Further studies are indicated to determine most dose prednisone, appropriate duration treatment,...
Functional evaluation of the pars intermedia (PI) is required for early diagnosis equine pituitary PI dysfunction (PPID), yet most assays target hypothalamic-pituitary-adrenal axis, which regulates anterior. In contrast, regulated by dopaminergic tone from hypothalamic neurons. Loss inhibition hypothesized to cause hypertrophy and hyperplasia that result in clinical manifestations PPID. Domperidone, a dopamine receptor antagonist, should exacerbate loss horses with PPID increase release...
The goal of this study was to investigate whether treatment with bezafibrate improves glucose tolerance in non-insulin-dependent diabetes mellitus (NIDDM). included 37 NIDDM patients HbA1 concentrations >8.5% and normal kidney liver function who were being treated diet alone or together a sulfonylurea drug. One patient withdrew because constipation. At randomization after 3 mo treatment, given standard mixed-test-meal test (MTT; 500 cal) an overnight fast, plasma glucose, insulin,...
Abstract Mammary intraepithelial lesions (IEL) are nowadays frequently diagnosed as a result of the success mammographic screening, education programs, and awareness by women. Establishment an animal model for these to test treatment or preventive modalities is prerequisite human clinical trials. A spontaneous IELs, especially estrogen receptor (ER)-negative lesions, does not exist. This study describes histologic immunohistochemical similarity between canine mammary IELs. tumors from 200...
Breast cancer is the most frequently diagnosed in women. Intraepithelial lesions (IELs), such as usual ductal hyperplasia (UH), atypical (ADH), and carcinoma situ (DCIS) are risk factors that predict a woman's chance of developing invasive breast cancer. Therefore, comparative study establishes an animal model pre-invasive needed for development preventative measures effective treatment both mammary IELs tumors. The purpose this was to characterize histologic molecular features feline...
Postmortem findings in 241 equids admitted to a teaching hospital that were at least 15 years old autopsy reviewed (1) determine disease prevalence, (2) compare the cause of death (or euthanasia) 19 age (n = 116) with ≥20 125), and (3) catalog coexisting lesions pituitary pars intermedia dysfunction (PPID). Breed sex evenly distributed between groups. Death or euthanasia was attributed digestive system (41.5%), gland (12.9%), locomotor (10.0%), nervous (7.9%), cardiovascular (4.6%), urinary...
Standardization of tumor assessment lays the foundation for validation grading systems, permits reproducibility oncologic studies among investigators, and increases confidence in significance study results. Currently, there is minimal methodological standardization assessing tumors veterinary medicine, with few attempts to validate published protocols schemes. The current article address these shortcomings by providing standard guidelines parameters evaluating specific types. More detailed...
Thirteen uterine tumors were diagnosed in 13 cats and accounted for 0.29% of all feline neoplasms received during a 9.6-year period. Age at diagnosis ranged from 3 to 16 years; median 9 years. Six Domestic Shorthair cats, 7 purebred 5 different breeds. Eight adenocarcinomas 1 mixed Müllerian tumor (adenosarcoma) comprised the endometrial tumors. Myometrial included leiomyomas leiomyosarcoma. One developed stump an ovario-hysterectomized cat; other sexually intact. Concurrent mammary...
Several uncontrolled studies suggest octreotide is beneficial in thyroid-associated ophthalmopathy (TAO); however, the natural tendency of TAO to improve mandates randomized, controlled trials.