A5068225519- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Microbial infections and disease research
- Toxic Organic Pollutants Impact
- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Veterinary Oncology Research
- Viral Infections and Vectors
- Toxoplasma gondii Research Studies
- Animal Disease Management and Epidemiology
- Mercury impact and mitigation studies
- Effects and risks of endocrine disrupting chemicals
- Virology and Viral Diseases
- Infectious Diseases and Tuberculosis
- Viral gastroenteritis research and epidemiology
- Bird parasitology and diseases
- Infectious Diseases and Mycology
- Mosquito-borne diseases and control
- Reproductive biology and impacts on aquatic species
- Vector-Borne Animal Diseases
- Rabies epidemiology and control
- Aquaculture disease management and microbiota
- Environmental Toxicology and Ecotoxicology
- Carcinogens and Genotoxicity Assessment
Michigan State University
2014-2024
Pacific Northwest National Laboratory
2019-2022
National Cancer Institute
2018
Cornell University
2018
DNA Diagnostic (Denmark)
2018
University of Florida
2017
North Carolina State University
2016
University of New Hampshire
2016
Animal and Plant Health Inspection Service
2016
Michigan Department of Agriculture and Rural Development
2016
Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists institutional modifications make value highly questionable. To evaluate consistency microscopic among significance Patnaik system, 95 MCTs from dogs were graded in a blinded study 28 16 institutions. Concordance was 75% diagnosis grade 3 less than 64% 1 2 MCTs. improve concordance to...
Abstract We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout United States during April 1‒July 21, 2022. Affected include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), fisher (Pekania pennanti), and gray fox (Urocyon...
A 4.5 yr-old male white-tailed deer (Odocoileus virginianus) killed by a hunter during the 1994 firearm hunting season in northeastern Michigan (USA) had lesions suggestive of tuberculosis and was positive on culture for Mycobacterium bovis causative agent bovine tuberculosis. Subsequently, survey 354 hunter-harvested conducted this area from 15 November 1995 through 5 January 1996. Heads and/or lungs were examined grossly microscopically Gross seen deer. Tissues 16 acid-fast bacilli...
A retrospective study was conducted to test the hypothesis that supplemental feeding of white-tailed deer (Odocoileus virginianus) from 1995 1997 associated with prevalence bovine tuberculosis (TB) in free-ranging northeastern Michigan. Bovine TB data were obtained an ongoing surveillance program, while relating and other risk factors collected via in-person interviews. multivariable Poisson regression modeling approach used stated controlling for factors. Of 389 potential participants, 59%...
The purpose of this study was to assess the effect humidity and packaging materials on stability iodine in typical salt samples from countries with tropical subtropical climates, under controlled climatic conditions. Initially we examined eight samples. In second phase expanded salts 18 sources attempted correlate observed impurities naturally present these High resulted rapid loss iodized potassium iodate, ranging 30% 98% original content. Solid low-density polyethylene protected a great...
Background and Purpose— An urgent need exists to develop therapies for stroke that have high efficacy, long therapeutic time windows, acceptable toxicity. We undertook preclinical investigations of a novel approach involving supplementation with carnosine, an endogenous pleiotropic dipeptide. Methods— Efficacy safety carnosine treatment was evaluated in rat models permanent or transient middle cerebral artery occlusion. Mechanistic studies used primary neuronal/astrocytic cultures ex vivo...
Abstract Fifty white leghorn chicken ( Gallus domesticus ) eggs per group were injected with 0.1, 1.0, 10.0, or 20.0 μg perfluorooctane sulfonate (PFOS)/g egg before incubation to investigate the effects of PFOS on developing embryo. Hatchlings weighed, examined for gross developmental abnormalities, and transferred a battery brooder, where they raised 7 d. Chicks then 20 birds treatment randomly chosen necropsy. The brain, heart, kidneys, liver removed weighed. Livers processed further...
During a survey of carnivores and omnivores for bovine tuberculosis conducted in Michigan (USA) since 1996, Mycobacterium bovis was cultured from lymph nodes pooled six coyotes (Canis latrans) (four adult female, two male), male raccoons (Procyon lotor), one red fox (Vulpes vulpes), 1.5-yr-old black bear (Ursus americanus). One adult, bobcat (Felis rufus) with histologic lesions suggestive negative on culture but positive organisms belonging to the complex when tested by polymerase chain...
This study was conducted with 3 objectives in mind: first, to identify the toxic fraction (aqueous or organic) leaves and flowers; second, diagnostic marker(s) of toxicosis cats; and, third, evaluate morphologic effects intoxication. The 2 phases. Phase 1 which extract, organic aqueous, nephrotoxic also determine appropriate dose for use phase studies. Results indicated that only aqueous extracts flowers were pancreotoxic. To proximate compound, cats orally exposed subfractions flower...
Parasites threaten human and animal health globally. It is estimated that more than 60% of people on planet Earth carry at least one parasite, many them several different species. Unfortunately, parasite studies suffer from duplications inconsistencies between investigator groups. Hence, groups need to collaborate in an integrated manner areas including control, improved therapy strategies, diagnostic surveillance tools, public awareness. Parasite will be better served if there coordinated...
Asiatic acid (AA) has been shown to attenuate cerebral infarction in a mouse model of focal ischemia and shows promise as neuroprotective stroke therapy. To facilitate translation these findings clinical studies, we determined pharmacokinetics, dose-response relationship, the therapeutic time window, efficacy using multiple models. We also explored potential mechanisms action.Escalating doses intravenous AA were administered serum concentrations measured at points for pharmacokinetic...
Egg injection studies were performed to confirm a proposed model of relative sensitivity birds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this model, species are classified as belonging one three categories based on amino acid substitutions in the ligand-binding domain aryl hydrocarbon receptor. Embryo lethality and potencies 2,3,7,8-tetrachlorodibenzofuran (TCDF) 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) compared with TCDD for Japanese quail (Coturnix japonica; least sensitive), Common...
Excessive unexplained mortality was observed in flocks of double-crested cormorants located at Snake Island Green Bay, Michigan, June 1992. Clinical signs included weakness, lethargy, diarrhea, respiratory distress, paralysis the wings and legs, torticollis, incoordination. The most significant consistent gross lesions edema eyelids periocular tissues, pulmonary congestion, marked splenomegaly, hepatic necrosis, scattered hemorrhages visceral organs. Histologically, principal alterations...
Descriptions of the anatomical distribution Mycobacterium bovis gross lesions in large samples white-tailed deer (Odocoileus virginianus) are lacking scientific literature. This report describes 58 that cultured positive for M. among 19,500 submitted tuberculosis testing Michigan (USA) 1999. For vast majority (19,348) those tested, only head was submitted; others, extracranial tissues (33) or both and (119) were available. Among positive, cranial noted most frequently medial retropharyngeal...
Since the initial report of West Nile virus in northeastern United States 1999, has spread rapidly westward and southward across country. In summer 2002, several midwestern states reported increased cases neurologic disease mortality associated with infection various native North American owl species. This summarizes clinical pathologic findings for 13 captive free-ranging owls. Affected species were all family Strigidae included seven snowy owls (Nyctea scandiaca), four great-horned (Bubo...
The Las Vegas Wash (LW) delivers tertiary-treated municipal wastewater effluent, nonpotable shallow groundwater seepage, and runoff from the urbanized Valley to Bay (LX) of Lake Mead. To investigate potential for contaminants in LW influent produce effects indicative endocrine disruption vivo, adult male female common carp (Cyprinus carpio) were exposed cages 42−48 d at four sites Mead: LW, LX, two reference locations lake. End points examined included gonadosomatic index; gonad histology;...
Bovine tuberculosis (bTb) was diagnosed in 22 cattle herds the northeast corner of Michigan's lower peninsula. Of these herds, 494 animals 7 were examined by gross necropsy, histopathologic exam, mycobacterial culture, and polymerase chain reaction (PCR) assay performed only on samples that histologically compatible for bTb. Results culture PCR interpreted parallel used as reference test calculation sensitivity 1) caudal fold (CFT), 2) comparative cervical skin tests series (CFTCCT SER ), 3)...