A5029578078- Influenza Virus Research Studies
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Zoonotic diseases and public health
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Microbial infections and disease research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Data-Driven Disease Surveillance
- Vector-Borne Animal Diseases
- Species Distribution and Climate Change
- Wildlife Ecology and Conservation
Animal and Plant Health Inspection Service
2021-2024
United States Department of Agriculture
2022-2024
Collins College
2021-2023
Life Services (United States)
2023
Universidade de São Paulo
2023
University of Arkansas System
2023
National University of San Marcos
2023
University of Arkansas at Fayetteville
2023
National Wildlife Research Center
2022
National Wildlife Health Center
2016
Widespread human SARS-CoV-2 infections combined with human-wildlife interactions create the potential for reverse zoonosis from humans to wildlife. We targeted white-tailed deer (Odocoileus virginianus) serosurveillance based on evidence these have angiotensin-converting enzyme 2 receptors high affinity SARS-CoV-2, are permissive infection, exhibit sustained viral shedding, can transmit conspecifics, social behavior, and be abundant near urban centers. evaluated 624 prepandemic postpandemic...
We report the spillover of highly pathogenic avian influenza A(H5N1) into marine mammals in northeastern United States, coincident with H5N1 sympatric wild birds. Our data indicate monitoring both coastal birds and will be critical to determine pandemic potential A viruses.
We detected Eurasian-origin highly pathogenic avian influenza A(H5N1) virus belonging to the Gs/GD lineage, clade 2.3.4.4b, in wild waterfowl 2 Atlantic coastal states United States. Bird banding data showed widespread movement of within Flyway and between neighboring flyways northern breeding grounds.
Highly pathogenic avian influenza viruses (HPAIVs) of the A/goose/Guangdong/1/1996 lineage H5 clade 2.3.4.4b continue to have a devastating effect on domestic and wild birds. Full genome sequence analyses using 1369 H5N1 HPAIVs detected in United States (U.S.) birds, commercial poultry, backyard flocks from December 2021 April 2022, showed three phylogenetically distinct virus introductions U.S. by Unreassorted Eurasian genotypes A1 A2 entered Northeast Atlantic states, whereas genetically...
Abstract We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout United States during April 1‒July 21, 2022. Affected include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), fisher (Pekania pennanti), and gray fox (Urocyon...
Abstract SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of from humans to free-ranging white-tailed deer ( Odocoileus virginianus ) poses unique public health risk due the potential for reservoir establishment where variants may persist evolve. We collected 8,830 respiratory samples across Washington, D.C. 26 states in United States November 2021 April 2022. obtained 391 sequences identified 34 Pango lineages including...
Abstract The zoonotic origin of the COVID-19 pandemic virus highlights need to fill vast gaps in our knowledge SARS-CoV-2 ecology and evolution non-human hosts. Here, we detected that was introduced from humans into white-tailed deer more than 30 times Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds kilometers. Newly developed Bayesian phylogenetic methods quantified how is not only three-times faster...
The host tropism expansion of SARS-CoV-2 raises concern for the potential risk reverse-zoonotic transmission emerging variants into rodent species, including wild rat species. In this study, we present both genetic and serological evidence exposure to New York City population, these viruses may be linked that were circulating during early stages pandemic.
Abstract The recent incursion of Highly Pathogenic Avian Influenza A (H5N1) virus into North America and subsequent dissemination across the continent, has had significant adverse impacts on domestic poultry, led to widespread mortality in many wild bird species. Here we report spillover H5N1 marine mammals northeastern United States, with associated a regional scale. This is coincident second wave sympatric birds also experiencing events. Viral sequences derived from both seal avian hosts...
While SARS-CoV-2 has sporadically infected a wide range of animal species worldwide1, the virus been repeatedly and frequently detected in white-tailed deer North America2â€"7. The zoonotic origins this pandemic highlight need to fill vast gaps our knowledge ecology evolution non-human hosts. Here, we was introduced from humans into more than 30 times Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2-8 months, which disseminated across...
Abstract Broad-scale data show SARS-CoV-2 occurrence in white-tailed deer throughout much of their range the conterminous United States and reinforce findings considerable infection exposure. Results shed light on both current infections prior exposure, with prevalence decreasing over time seroprevalence increasing. One-Sentence Summary White-tailed are infected with, have been exposed to, US.
The ongoing panzootic of highly pathogenic H5 clade 2.3.4.4b avian influenza (HPAI) spread to North America in late 2021, with detections HPAI viruses Alaska beginning April 2022. have since across the state, affecting many species wild birds as well domestic poultry and mammals. To better understand dissemination spatiotemporally among hosts adjacent regions, we compared genomes 177 confirmed detected during April-December Results suggest multiple viral introductions into between November...
Abstract Widespread human SARS-CoV-2 infections combined with human-wildlife interactions create the potential for reverse zoonosis from humans to wildlife. We targeted white-tailed deer ( Odocoileus virginianus ) serosurveillance based on evidence these have ACE2 receptors high affinity SARS-CoV-2, are permissive infection, exhibit sustained viral shedding, can transmit conspecifics, and be abundant near urban centers. evaluated 624 pre- post-pandemic serum samples wild four U.S. states...
Highly pathogenic avian influenza viruses (HPAIVs) of subtype H5 the Gs/GD/96 lineage remain a major threat to poultry due endemicity in wild birds. H5N1 HPAIVs from this were detected 2021 United States (U.S.) and since then have infected many domestic We evaluated pathobiology an early U.S. HPAIV (clade 2.3.4.4b, 2021) two H5N8 previous outbreaks 2.3.4.4c, 2014) Europe 2016) chickens turkeys. Differences clinical signs, mean death times (MDTs), virus transmissibility found between The bird...
Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans human animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal Plant Health Inspection Service State Natural Resources Agencies to quantify the outbreak dynamics SARS-CoV-2 North American white-tailed deer (Odocoileus virginianus; WTD) throughout its range States. Local epidemics WTD were well approximated...
Rabbit hemorrhagic disease virus 2 (RHDV2) is a highly infectious, often fatal viral that affects both domestic and wild lagomorph species. In the United States (U.S.), first was detected in populations southwest March 2020 has continued to be native North American species over several years. The susceptibility of host exact mechanisms environmental transmission across U.S. landscape remain poorly understood. Our study aims increase understanding RHDV2 by providing history detection. We...
The global outbreak of highly pathogenic avian influenza (HPAI) H5N1 Eurasian lineage goose/Guangdong clade 2.3.4.4b virus that was detected in North America 2021 is the largest history and has significantly impacted wild bird populations domestic poultry across continent. Synanthropic birds may play an important role transmitting laterally to other species poultry. Understanding dynamics HPAI atypical, or nonreservoir, hosts help inform management decisions potential risk factors both...
The introduction of HPAI H5N1 clade 2.3.4.4b viruses to North America in late 2021 resulted avian influenza outbreaks poultry, mortality events many wild bird species, and spillovers into mammalian species. Reassortment with American low-pathogenic virus were identified as early February 2022 over 100 genotypes have been characterized. Such diversity increases the complexity time required for monitoring evolution. Here, we performed ordination clustering analyses on sequence data from...
Abstract Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans human animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal Plant Health Inspection Service state natural resources agencies to quantify infection SARS-CoV-2 North American white-tailed deer ( Odocoileus virginianus ; WTD) using hierarchical epidemiological model the eastern half States. Our found...
Millions of Norway rats (Rattus norvegicus) inhabit New York City (NYC), presenting the potential for transmission SARS-CoV-2 from humans to and other wildlife. We evaluated exposure among 79 captured NYC during fall 2021. Results showed that 13 (16.5%) tested IgG or IgM positive, partial genomes were recovered four qRT-PCR positive. Using a virus challenge study, we also Alpha, Delta, Omicron variants can cause robust infections in wild-type Sprague Dawley (SD) rats, including high level...
ObjectiveThe USGS National Wildlife Health Center in conjunction with federal, state, tribal partners proposed an event reporting system current and historic information on wildlife morbidity mortality events North America.The vehicle to accomplish this goal is WHISPers, the Information Sharing Partnership system.This depicts laboratory confirmed using geospatial mapping capability.Data are collected by multiple collectively enhance understanding of disease populations.
Abstract Eurasian-origin highly pathogenic avian influenza A(H5N1) belonging to the Gs/GD lineage, clade 2.3.4.4b, was detected in two Atlantic states wild waterfowl United States January 2022. Bird banding data show widespread movement of both within Flyway and between neighboring flyways northern breeding grounds.
Abstract Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans human animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal Plant Health Inspection Service state natural resources agencies to quantify outbreak dynamics SARS-CoV-2 North American white-tailed deer ( Odocoileus virginianus ; WTD) throughout its range the States. Local epidemics WTD were well...
Abstract Understanding pathogen emergence in new host species is fundamental for developing prevention and response plans human animal health. We leveraged a large-scale surveillance dataset coordinated by United States Department of Agriculture, Animal Plant Health Inspection Service state natural resources agencies to quantify outbreak dynamics SARS-CoV-2 North American white-tailed deer ( Odocoileus virginianus ; WTD) throughout its range the States. Local epidemics WTD were well...