A5052993017- Eicosanoids and Hypertension Pharmacology
- Metabolomics and Mass Spectrometry Studies
- Virus-based gene therapy research
- Pharmacogenetics and Drug Metabolism
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Inflammatory mediators and NSAID effects
- melanin and skin pigmentation
- Hair Growth and Disorders
- Herpesvirus Infections and Treatments
- Biomedical and Engineering Education
- Respiratory viral infections research
- Receptor Mechanisms and Signaling
- Microbial infections and disease research
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Animal Disease Management and Epidemiology
- Gut microbiota and health
Washington State University
2009-2024
Agricultural Research Service
2009
Animal and Plant Health Inspection Service
2009
United States Department of Agriculture
2009
Abstract We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout United States during April 1‒July 21, 2022. Affected include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), fisher (Pekania pennanti), and gray fox (Urocyon...
Rabbit hemorrhagic disease virus 2 (RHDV2) causes an often-fatal of rabbits that has resulted in outbreaks rabbitries Europe, Africa, Australia, and Asia. RHD historically been characterized as a foreign animal the United States. In July 2019, RHDV2 was detected on Orcas Island along northwestern coast Washington (WA) State following reports deaths multiple feral domestic rabbits. We document highlight here unique clinical presentation gross histologic lesions observed this recent WA...
A caprine arthritis-encephalitis virus (CAEV)/maedi-visna (MVV) indirect enzyme-linked immunosorbent assay (iELISA) was validated with samples from U.S. sheep and by the use of radioimmunoprecipitation as standard for comparison. The sensitivity specificity were 86.0% (+ or - 5.8%) 95.9% 2.9%), respectively. iELISA format phylogenetic differences based on MVV gag sequence contribute to reduced sensitivity.
Prediction and early detection of kidney damage induced by nonsteroidal anti-inflammatories (NSAIDs) would provide the best chances maximizing anti-inflammatory effects while minimizing risk damage. Unfortunately, biomarkers for detecting NSAID-induced in cats remain to be discovered. To identify potential urinary monitoring NSAID-based treatments, we applied an untargeted metabolomics approach urine collected from treated repeatedly with meloxicam or saline up 17 days. Applying multivariate...
Non-steroidal anti-inflammatories (NSAIDs), such as meloxicam, are the mainstay for treating painful and inflammatory conditions in animals humans; however, repeated administration of NSAIDs can cause adverse effects, limiting long-term these drugs to some patients. The primary aim this study was determine effects meloxicam on feline plasma urine lipidome. Cats (n = 12) were treated subcutaneously with either saline solution or 0.3 mg/kg body weight daily up 31 days. Plasma lipidome...
Abstract Repeated administration of meloxicam to cats is often limited by the potential damage multiple organ systems. Identifying molecules that predict adverse effects would help monitor and individualize its administration, maximizing meloxicam's beneficial effects. The objectives this study were (a) determine if repeated alters plasma metabolome (b) identify metabolites may serve during in cats. Purpose bred young adult ( n = 12) treated with at 0.3 mg/kg or saline subcutaneously once...
Abstract Repeated administration of meloxicam can cause kidney damage in cats by mechanisms that remain unclear. Metabolomics and lipidomics are powerful, noninvasive approaches used to investigate tissue response drug exposure. Thus, the objective this study was assess effects on feline using untargeted metabolomics approaches. Female young‐adult purpose‐breed were allocated into control ( n = 4) groups. Cats groups treated daily with saline at 0.3 mg/kg subcutaneously for 17 days,...
A new method of experimental infection ovine progressive pneumonia virus (OPPV), aerosol nebulization (Nb), was compared to intravenous (IV) and oral (PO) methods infection. Seven month old lambs were given 3.5 × 107 TCID50 Dubois OPPV LMH19 isolate using IV, PO, or Nb monitored for cELISA quantitative (q) PCR 35 weeks. Four out four sheep in the IV group, six but only two PO group became infected by OPPV; whereas uninoculated controls (n = 2) a sentinel control 1) remained uninfected during...
Serum symmetric dimethylarginine (SDMA) and creatinine are commonly used biomarkers of renal function in cats. We hypothesize that the serum analytes SDMA equally effective at detecting impaired caused by meloxicam-induced injury Our primary objective was to compare concentrations cats before, during, after induction from repeated dosages meloxicam context a small pilot study.
Hair quality is an important indicator of health in humans and other animals. Current approaches to assess hair are generally non-quantitative or low throughput due technical limitations 'splitting hairs'. We developed a deep learning-based computer vision approach for the high quantification individual fibers at resolution. Our innovative tool can distinguish extract overlapping multivariate features including length, width, color generate single-hair phenomes (shPhenome) diverse conditions...