A5100779706- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Herpesvirus Infections and Treatments
- Medicinal Plant Pharmacodynamics Research
- Animal Disease Management and Epidemiology
- Innovation and Socioeconomic Development
- Liver Disease and Transplantation
- Structural Response to Dynamic Loads
- Viral gastroenteritis research and epidemiology
- Pharmacology and Obesity Treatment
- Thyroid Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Berberine and alkaloids research
- Advanced MRI Techniques and Applications
- MicroRNA in disease regulation
- Concrete Corrosion and Durability
- Artificial Intelligence in Healthcare
- Research, Science, and Academia
- Vascular Malformations and Hemangiomas
- Ophthalmology and Eye Disorders
- Cytomegalovirus and herpesvirus research
- Advanced Photocatalysis Techniques
- Photodynamic Therapy Research Studies
Guizhou Provincial People's Hospital
2024
Tongji University
2006-2022
Shanghai Tenth People's Hospital
2014-2022
Hubei Cancer Hospital
2022
Affiliated Hospital of North Sichuan Medical College
2021
Northeastern University
2015-2019
Shanghai Pulmonary Hospital
2013-2018
Washington State University
2009-2012
Agricultural Research Service
2009-2012
Tongji Hospital
2011
Losartan and berberine (BBR) are often simultaneously used for the treatment of senile diabetic nephropathy in clinics. However, potential herb-drug interaction between losartan BBR is unknown.This study investigates influence on pharmacokinetics EXP3174, effects metabolic stability losartan.The pharmacokinetic profiles EXP3174 orally administered (10 mg/kg) with without pretreatment (20 within 24 h were determined Sprague-Dawley rats. The inhibitory investigated using rat liver...
Azithromycin (AZM), that is a macrolide antibiotic, has been found to treat diffuse panbronchiolitis (DPB) effectively. However, the mechanism of action underlying therapeutic effects remains unclear. We selected 64 patients with DPB from 305 who were diagnosed at outpatient clinic in Shanghai Pulmonary Hospital Jan 2010 Oct 2014. The primary PBLs, CD4 + T cells, and Jurkat cells treated AZM or erythromycin (EM), EM on IL-17A CXCL-2 production, proliferation, apoptosis autophagy evaluated....
Two cases of sheep-associated malignant catarrhal fever (MCF) in pigs were diagnosed on a small farm New York, and Kentucky. In both cases, the initial diagnosis was based histopathological changes representing typical lymphoproliferative vasculitis multiple tissues affected pigs. Ovine herpesvirus 2 (OvHV-2) DNA detected by polymerase chain reaction cases. The amplified sequences identical between clinically OvHV-2-infected sheep. Additional virological bacteriological examination showed...
A novel and facile photoelectrochemical method has been developed to detect H(2)S in water samples with high sensitivity selectivity. The protocol is based on the photocurrent generated by CdS nanoclusters which are deposited onto TiO(2) nanotubes exposing CdSO(4) solution gradual addition of Na(2)S, low-cost, environment-friendly, theoretical technical simplicity. shows a very broad linear range from 10(-8) M 10(-3) low detection limit 0.31 nM (9.92 ppt), far lower than ceiling value...
The co-administration of abemaciclib and astragaloside IV might occur in the treatment breast cancer.This study evaluates interaction between rats describes potential mechanism.Male Sprague Dawley were randomly divided into four groups: single dose (control), + 50 mg/kg/d IV, 100 150 IV. Abemaciclib orally administrated, was pre-administrated for 7 d co-administrated groups. pharmacokinetics transport assessed absence or presence In mechanism, activity CYP3A4 estimated human liver microsomes...
Virus entry is a multistep process that triggers various cellular pathways interconnect into complex network; yet the molecular complexity of this network remains largely elusive. Here, by employing systems biology approaches, we reveal systemic virus-entry initiated human cytomegalovirus (HCMV), widespread opportunistic pathogen. This contains ten functional modules (i.e., groups proteins) coordinately respond to HCMV entry. Functional activated (up- and downregulated) in dramatically...
This study was to evaluate the expression of miR-129-5p in non-alcoholic fatty liver (NAFLD) patients and its clinical value explore regulatory effect on insulin resistance (IR). A total 117 NAFLD 110 healthy controls were included. The levels detected by qRT-PCR. To assess diagnostic for NAFLD, receiver operating characteristic curve (ROC) established. C57Bl/6 mice supplied with high-fat diet establish model. Intraperitoneal tolerance test (IPITT) carried out IR animal highly expressed...
Acute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim this study is to investigate clinical significance TSH alteration patients with ACVD.Patients ACVD admitted our hospitals between January 2013 and September 2017 were enrolled (n = 245, including 176 cerebral infarctions 69 hemorrhages)....
Myocardial elastography (ME) is a strain imaging technique used to diagnose myocardial diseases. Axial and lateral displacement calculations are pre-conditions of image acquisition in ME. W.N. Lee et al. proposed normalized cross-correlation (NCC) recorrelation method obtain both axial displacements However, this not noise-resistant high computational cost. This paper proposes predicted fast NCC algorithm based on Lee's method, with the additions sum-table prediction algorithm, efficient...
A new method of experimental infection ovine progressive pneumonia virus (OPPV), aerosol nebulization (Nb), was compared to intravenous (IV) and oral (PO) methods infection. Seven month old lambs were given 3.5 × 107 TCID50 Dubois OPPV LMH19 isolate using IV, PO, or Nb monitored for cELISA quantitative (q) PCR 35 weeks. Four out four sheep in the IV group, six but only two PO group became infected by OPPV; whereas uninoculated controls (n = 2) a sentinel control 1) remained uninfected during...
This study aims to assess the value of ultrasound real-time shear wave elastography (US-SWE) for evaluation nonalcoholic fatty liver disease (NAFLD) in a rabbit model compared with multislice computed tomography (MSCT).Twenty-six rabbits were fed high-fat, high-cholesterol diet and six standard diet. All performed MSCT US-SWE at various time points measure changes parenchyma. The diagnostic efficiency was analyzed using receiver operating characteristics (ROC) curves based on pathology.The...
Recombinant human type II tumour necrosis factor receptor-antibody fusion protein (rh TNFR:Fc) is an immunosuppressant approved for treating rheumatoid arthritis (RA). This case report describes a of hepatitis B reactivation in patient with drug-induced acute-on-chronic liver failure. A 58-year-old woman history RA was treated rh TNFR:Fc; and then subsequently received 25 mg TNFR:Fc, twice week, as maintenance therapy. No anti-hepatitis virus (HBV) preventive treatment administered. Six...
Objective To study the changes of bone mineral density(BMD)and turnover in postmenopausal osteoporotic patients treated with salmon calcitonin nasal spray. Methods Sixty-seven were enrolled our trial. All them received calcium and vitamin D; 37patients spray for 12 months other 30 D only. Dual-energy X-ray absorptiometry(DEXA)and measurements a series indices performed before after medication 6 months. Results After treatment for6 months, BMD lumbar spine 2-4 increased but no change occurred...
To report a rare case of atypical histiocytic tumor the lung with review literature.The clinical materials were noted. Literature related to this condition from past 50 years was reviewed group tumors.Clinical manifestations non-specific. The imaging characteristics our infiltrative lesions multiple cysts in both lungs. Pathology showed nodular proliferation cells. Immunohistochemistry suggested origin infiltrating Because pathological findings did not fall into any particular category...
This paper was aimed to investigate the effects of icariin on expression p38 mitogen activated protein kinase(MAPK)protein in rat osteoblasts cultured vitro, elucidate signal transduction preventing and treating osteoporosis. The results showed that p38MAPK could be by within 5min, Cbfal also upregulated, SB203580, an inhibitor pathway, partly inhibit upregulation icariin. Key words: Icariin; p38MAPK; Cbfa1; Osteoblasts; Osteoporosis