A5084154095- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Respiratory viral infections research
- Connexins and lens biology
- Immunotherapy and Immune Responses
- Dermatological and COVID-19 studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Renal and related cancers
- Cervical Cancer and HPV Research
- Silk-based biomaterials and applications
- Hereditary Neurological Disorders
- Urticaria and Related Conditions
- RNA regulation and disease
- Infection Control and Ventilation
- Endometriosis Research and Treatment
- Pesticide Residue Analysis and Safety
- Antimicrobial Peptides and Activities
- Viral-associated cancers and disorders
- Health, Environment, Cognitive Aging
- Herpesvirus Infections and Treatments
- Trace Elements in Health
- Oral and Maxillofacial Pathology
- Bacterial Infections and Vaccines
University of California, Davis
2018-2025
Michigan State University
2018
CD4 T follicular helper (Tfh) cells are important for the generation of durable and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates Tfh stimulates germinal center (GC) response is an question as we investigate vaccine induced immunity COVID-19. Here, report that in rhesus macaques, either infused with convalescent plasma, normal or receiving no infusion, resulted transient accumulation pro-inflammatory monocytes proliferating a Th1...
Introduction Lung diseases are widespread worldwide. Pulmonary immunity plays a vital role against lung pathogens, including SARS-CoV-2 infection. Understanding the pathogenesis, development of local immune responses to infection, is fundamental for developing interventions control viral Methods Using immunohistochemistry, we investigated distribution cells in lungs rhesus macaques experimentally infected with and euthanized 11–14 days later. Results Tertiary lymphoid tissue was found all...
Canine oral papillomavirus (CPV1, also known as COPV), the most common cause of non-neoplastic papillomas, has not been shown to squamous cell carcinomas (SCC). Furthermore, malignant transformation benign papillomas SCC only reported in a single group dogs with severe combined immunodeficiency infected CPV2. Here, we report series 7 CPV1-associated histologic evidence CPV1 causing carcinoma situ and ultimately SCC. Expression p53 p16 proteins CPV1-infected cells within lesions that...
Abstract Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent blunt disease. Here, we examine the efficacy of aerosol mAb delivery to and disease in rhesus macaques inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant via intranasal intratracheal routes. SARS-CoV-2 human mAbs a directed syncytial virus (RSV) are nebulized delivered using positive airflow facemask sedated pre- post-infection. Nebulized...
Background Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defects copper metabolism have exacerbated by increased environmental exposure. However, no broad epidemiological investigations performed to investigate quantitative hepatic concentrations ([Cu] H ) over time both dogs are (predisposed breed [PB]), not (non‐predisposed [NPB]), considered at‐risk for CAH. Objectives To [Cu] explore temporal, demographic, histologic...
The U.S. Food and Drug Administration only gave emergency use authorization of the BNT162b2 mRNA-1273 SARS-CoV-2 vaccines for infants 6 months older in June 2022. Yet questions regarding durability vaccine efficacy, especially against emerging variants, this age group remain. We demonstrated previously that a two-dose regimen stabilized prefusion Washington S-2P spike (S) protein encoded by mRNA encapsulated lipid nanoparticles (mRNA-LNP) or purified mixed with 3M-052, synthetic Toll-like...
Abstract In March 2017, 26 American goldfinches ( Spinus tristis ) were found dead following a drench application of imidacloprid in California (USA). Identical seed fragments present the digestive tracts. Imidacloprid was detected 4 separate pooled samples from 18 birds, crop/gizzard contents (4.8 ± 1.3 ppm; range 2.2–8.5 ppm) and liver tissues (3.9 0.6 2.1–4.8 ppm). We suspect that fallen elm Ulmus sp.) seeds contaminated with during subsequently ingested, resulting acute toxicity death....
There is an urgent need for effective therapeutic interventions against SARS-CoV-2, including new variants that continue to arise. Neutralizing monoclonal antibodies have shown promise in clinical studies. We investigated the efficacy of a combination two potent antibodies, C135-LS and C144-LS carry half-life extension mutations, rhesus macaque model COVID-19. Twelve young adult macaques (three groups four animals) were inoculated intranasally intra-tracheally with high dose SARS-CoV-2 24...
Human clinical studies investigating use of convalescent plasma (CP) for treatment coronavirus disease 2019 (COVID-19) have produced conflicting results. Outcomes in these may vary at least partly due to different timing CP administration relative symptom onset. The mechanisms action include neutralizing antibodies but extend beyond virus neutralization normalization blood clotting and dampening inflammation. Unresolved questions the minimum therapeutic titer units or recipient as well...
Early in the SARS-CoV-2 pandemic, there was a high level of optimism based on observational studies and small controlled trials that treating hospitalized patients with convalescent plasma from COVID-19 survivors (CCP) would be an important immunotherapy. However, as more data became available, results disappointing, at best moderate evidence efficacy when CCP titers neutralizing antibodies used early infection. To better understand potential therapeutic CCP, to further validate infection...
Abstract Introduction The majority of new HIV infections occur through mucosal transmission. availability readily applicable and accessible platforms for anti‐retroviral (ARV) delivery is critical the prevention acquisition sexual transmission in both women men. There a compelling need developing topical systems that have advantages over pills, gels rings, which currently fail to guarantee protection against viral vulnerable populations due lack user compliance. silk fibroin (SF) platform...
Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication both upper lower respiratory tracts aged, type 2 diabetic rhesus macaques. infusion dramatically curtails severe acute syndrome (SARS-CoV-2)-mediated...
ABSTRACT CD4 T follicular helper (T fh ) cells are important for the generation of long-lasting and specific humoral protection against viral infections. The degree to which SARS-CoV-2 infection generates stimulates germinal center response is an question as we investigate vaccine options current pandemic. Here report that, following with SARS-CoV-2, adult rhesus macaques exhibited transient accumulation activated, proliferating in their peripheral blood on a transitory basis. cell responses...
A geropathology grading platform (GGP) for assessing age-related lesions has been established and validated in inbred strain of mice. Because nonhuman primates (NHPs) share significant similarities aging spontaneous chronic diseases with humans, they provide excellent translational value correlating histopathology biological pathological events associated increasing age. Descriptive age-associated pathology described rhesus macaques marmosets, but a similar to the mouse GGP does not exist....
CD4 T follicular helper (T
Progressive neurologic signs without a known underlying etiology have been observed in managed gibbon populations housed at institutions North America. In 2018, the Gibbon Species Survival Plan initiated veterinary survey to evaluate clinical histories among gibbons displaying signs. The results of this as well centralized histologic review brain samples from 5 species are outlined here. Reported deficits surveyed included tremors (12/12, 100%), ataxia/incoordination (11/12, 92%), fine motor...
ABSTRACT Early in the SARS-CoV-2 pandemic, there was a high level of optimism based on observational studies and small controlled trials that treating hospitalized patients with convalescent plasma from COVID-19 survivors (CCP) would be an important immunotherapy. However, as more data became available, results disappointing, at best moderate evidence efficacy when CCP titers neutralizing antibodies used early infection. To better understand potential therapeutic CCP, to further validate...
Lymphoproliferative disorders of natural killer (NK)-cell lineage are well documented in humans but have yet to be non-human primates (NHPs). Here we describe a case NK-cell lymphoproliferative disorder/leukemia 20-y-old captive female rhesus macaque ( Macaca mulatta). The animal clinically had mild splenomegaly and marked lymphocytosis with small-to-medium lymphocytes blood smears. By flow cytometry cluster differentiation, the were CD3-negative, CD8-positive, CD4-negative, CD20-negative...
Abstract Pulmonary immunity against SARS-CoV-2 infection has not been well studied. This study investigated the distribution of immune cells int lungs 8 rhesus macaques experimentally infected with SARS-CoV-2, and euthanized 11-14 days later. Using immunohistochemistry, inducible bronchus-associated lymphoid tissue was found in all animals. The tissues were composed B cells, T follicular dendritic evidence lymphocyte priming differentiation. suggests local plays an important role infection....
<b><i>Introduction:</i></b> Open fetal surgery requires a hemostatic hysterotomy that minimizes membrane separation. For over 30 years, the standard of care for in gravid uterus has been AutoSuture Premium Poly CS*-57 stapler. <b><i>Objective:</i></b> In this study, we sought to test feasibility rhesus monkey model with Harmonic ACE®+7 Shears. <b><i>Methods:</i></b> A underwent midgestation at approximately 90 days...
Abstract The global spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and its associated coronavirus disease (COVID-19) has led to a pandemic unprecedented scale. An intriguing feature the infection is minimal in most children, demographic at higher risk for respiratory viral diseases. To elucidate age-dependent effects SARS-CoV-2 pathogenesis, we inoculated two rhesus macaque monkey dam-infant pairs with conducted virological transcriptomic analysis tract evaluated...
The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease (COVID-19) has led to a pandemic unprecedented scale. An intriguing feature the infection is minimal in most children, demographic at higher risk for other viral diseases. To investigate age-dependent effects SARS-CoV-2 pathogenesis, we inoculated two rhesus macaque monkey dam-infant pairs with conducted virological transcriptomic analyses tract evaluated systemic cytokine Ab...
Abstract This report describes the clinical and histological findings, genetic study, treatment in a 1.3‐year‐old rhesus macaque with bilateral cataracts unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased intraocular pressure from 56 to <2 mm Hg. A putative cause was not identified.