A5085192633- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Genomics and Rare Diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ocular Infections and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genetics, Aging, and Longevity in Model Organisms
- Chronic Disease Management Strategies
- Genetic factors in colorectal cancer
- Atherosclerosis and Cardiovascular Diseases
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- RNA Research and Splicing
- Nutrition, Genetics, and Disease
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- High Altitude and Hypoxia
- Advanced Glycation End Products research
- Substance Abuse Treatment and Outcomes
- Cancer therapeutics and mechanisms
- Frailty in Older Adults
University of Maryland, College Park
2019-2025
University of Maryland, Baltimore
2015-2024
Kermanshah University of Medical Sciences
2005-2023
Government Medical College and Hospital
2023
University of Washington
2022
Faculty of Public Health
2020
Yenepoya University
2017-2018
Tabriz University of Medical Sciences
2018
Alzahra Medical and Education Center
2018
Tehran University of Medical Sciences
2007-2016
Animal models of human cytomegalovirus (CMV) infections have not been available to study pathogenesis or evaluate antiviral drugs. Severe combined immunodeficient mice implanted with fetal tissues (SCID-hu) were found support CMV replication and may provide a model for this species-specific virus. When conjoint implants thymus liver inoculated low-passage-number isolate CMV, strain Toledo, consistent high-level viral was detected 5, 12, 15, 28, 35 days after inoculation virus continued up 9...
Impairment in glomerular endothelial function likely plays a major role the development of albuminuria and CKD progression. Glomerular dysfunction may reflect systemic microvascular dysfunction, accounting part for greater cardiovascular risk patients with albuminuria. Prior studies vascular have focused on conduit artery or those ESRD, not examined We conducted cross-sectional study among older hypertensive male veterans stage 1–4 CKD, controls without CKD. Microvascular was quantified by...
<b>Introduction:</b> Postpartum depression is a common mental health problem that associated with maternal suffering. The aim of this double-blind clinical trial was to compare safety and efficacy saffron fluoxetine in treatment mild moderate postpartum depression. <b>Methods:</b> This 6-week, double-blind, randomized trial. Subjects were women aged 18–45 years who had Hamilton Depression Rating Scale (HDRS 17-item) score≤18. Eligible participants receive either capsule (15 mg capsule) or...
The rate of decline renal function varies significantly among individuals with CKD. To understand better the contribution genetics to CKD progression, we performed a genome–wide association study participants in Chronic Renal Insufficiency Cohort Study. Our outcome interest was progression measured as change eGFR over time 1331 blacks and 1476 whites We stratified all analyses by race subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed significance threshold...
Abstract Several cloned lines of natural suppressor (NS) cells were studied for their expression the TCR complex. Almost all bore CD3+CD4-CD8- surface phenotype with alpha, beta as judged by immunofluorescent staining. Immunoprecipitation experiments showed a spot on two-dimensional gels which is characteristic heterodimer, but neither gamma- nor delta-chains could be precipitated appropriate antibodies. NS stimulated to proliferate in vitro anti-CD3 antibodies and PMA presence irradiated...
Objectives To examine the hypothesis that inflammatory state of aging is a risk factor for accelerated renal function ( RF ) decline using biomarkers and measures collected over 9 years follow‐up in relatively healthy individuals enrolled Invecchiare Chianti study. Design Longitudinal. Setting Community. Participants Individuals aged 60 older with baseline estimated glomerular filtration rate eGFR mL /min per 1.73 m 2 greater no diabetes mellitus DM (N = 687). Measures , as proxy was...
A bilateral simultaneous cataract surgery (BSCS) was performed on a 67-year-old man. The surgeon had not changed the surgical settings in between two procedures for eyes. patient developed fulminant endophthalmitis day following BSCS. Intravitreal culture grew Pseudomonas aeruginosa . source of infection found. Immediate vitrectomy and intravitreal, subconjunctival, topical systemic antibiotic did save Patient ended up with visual loss.
Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed nations. Bearing mind paucity effective treatment for DN and progressive CKD, novel targets are sorely needed. We previously reported that increased activity tonicity-responsive enhancer-binding protein (TonEBP) monocytes was associated with early humans. now extend these findings by testing hypotheses TonEBP macrophages promotes hyperglycemia-mediated proinflammatory activation chronic renal inflammation to...
Abstract Objective To determine the impact of sumatriptan prophylaxis on acute mountain sickness (AMS) and altitude headache development within 24 hours ascent, we designed a double‐blind, randomized, clinical trial. Methods A prospective, placebo‐controlled trial was conducted in Tochal Mountain Hotel at an 3,500 meters above sea level during October 2006 to November 2006. total 102 Iranian adults were assigned receive either succinate (50mg) or placebo 1 hour ascent. AMS incidence measured...
To evaluate the effect of topical antiglaucoma medications on lacrimal drainage system.In a prospective controlled blind observational case series, 627 eyes 384 patients (219 males, 165 females) were screened. Data recording (demographics and history taking), allocation in (on medications) control (no glaucoma) groups, examinations (eye examination dye disappearance test) performed by senior ophthalmology resident. Exclusion criteria epiphora prior to onset treatment with medication (only...
In the west, men are twice as likely women to develop a drug problem, but female users have higher rates of morbidity than male users. Iran has world highest per capita opiate consumption, little is known about 2007, we established free methadone clinic with ancillary services for in South Tehran. The aim was explore characteristics seeking treatment heroin dependence Iran. Clients were interviewed demographic characteristics, use and history, drug-related health problems. Urine blood...
BackgroundGenetic factors that influence kidney traits have been understudied for low frequency and ancestry-specific variants.MethodsWe combined whole genome sequencing (WGS) data from 23,732 participants 10 NHLBI Trans-Omics Precision Medicine (TOPMed) Program multi-ethnic studies to identify novel loci estimated glomerular filtration rate (eGFR). Participants included European, African, East Asian, Hispanic ancestries. We applied linear mixed models using a genetic relationship matrix the...
In general, information about women who use drugs comes from studies performed in the West. Whether countries such as Iran are likely to enter drug treatment or how they will respond is not known.To examine short-term impact of methadone maintenance (MMT) on use, dependence, social functioning, crime, and human immunodeficiency virus (HIV) hepatitis C (HCV) risk behavior seroincidence female users Iran.Women were eligible for inclusion study if assessed dependent opiates according...
AEOL 10150 is a catalytic metalloporphyrin superoxide dismutase mimic being developed as medical countermeasure for radiation-induced lung injury (RILI). The efficacy of against RILI through reduction oxidative stress, hypoxia and pro-apoptotic signals has been previously reported. goal this study was to determine the most effective dose (daily subcutaneous injections, day 1-28) in improving 180-day survival CBA/J mice after whole-thorax irradiation (WTLI) 14.6 Gy. Functional...
To determine the association of intimate partner violence with maternal cigarette smoking before and during pregnancy.
<b><i>Background:</i></b> Leukocytosis is a powerful predictor of incident chronic kidney disease (CKD) and related outcomes. However, the association between periodontitis measures increased leukocytosis in context CKD has not been well described. We sought to identify which individual periodontal may best associate with reduced estimated glomerular filtration rate (eGFR) albuminuria, test if these were associated subjects established CKD....
E-selectin mediates the rolling of circulating leukocytes during inflammatory processes. Previous genome-wide association studies in European and Asian individuals have identified ABO locus associated with levels. Using Trans-Omics for Precision Medicine whole genome sequencing data 2249 African Americans (AAs) from Jackson Heart Study, we examined associations soluble In addition to replicating known signals at ABO, a novel common loss-of-function, missense variant Fucosyltransferase 6...
Headache is the most prevalent symptom of acute mountain sickness. We conducted a pilot clinical trial at an altitude 3500 m to evaluate efficacy gabapentin in treatment high-altitude headache (HAH). Twenty-four adult HAH patients (10 female, 14 male; age 18-50 years) were randomly assigned receive either 300 mg capsule or identical placebo. After 1 h presence and need supplementary analgesic assessed. The duration HAH-free phase after taking additional was also registered. Four group asked...