A5056465662- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Assisted Reproductive Technology and Twin Pregnancy
- Fetal and Pediatric Neurological Disorders
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Spinal Dysraphism and Malformations
- Urological Disorders and Treatments
- Parvovirus B19 Infection Studies
- Pregnancy-related medical research
- Neonatal and fetal brain pathology
- Maternal and fetal healthcare
- Tracheal and airway disorders
- Ectopic Pregnancy Diagnosis and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiovascular Issues in Pregnancy
- Cardiac Structural Anomalies and Repair
- Pediatric Urology and Nephrology Studies
- Pelvic floor disorders treatments
Wayne State University
1999-2024
University of Michigan
2015-2024
Michigan Medicine
2011-2023
Women's Hospital
2012-2023
Beijing Obstetrics and Gynecology Hospital
2021
C. S. Mott Children's Hospital
2009-2020
University of North Carolina at Chapel Hill
2010-2020
Hutzel Women's Hospital
1995-2019
Michigan United
2017
Island Institute
2016
OBJECTIVE: The purpose of this study was to determine the prevalence and clinical significance microbial invasion amniotic cavity in patients presenting with cervical dilatation midtrimester pregnancy. STUDY DESIGN: Amniocentesis for studies performed women admitted ≥2 cm, intact membranes, without active labor between 14 24 weeks gestation. Amniotic fluid cultured aerobic anaerobic bacteria, as well mycoplasmas. Gram stain on all samples. RESULTS: 51.5% (17/33). most common isolates were...
To investigate the influence of physicians' practice styles on rate deliveries by cesarean section, we studied 1533 affluent women at low risk obstetrical complications who were cared for 11 obstetricians in a single community hospital. The mean delivery section was 26.9 percent, but ranged from 19.1 to 42.3 according physician. primary (i.e., without previous deliveries) 17.2, with range 9.6 31.8 percent. A stepwise logistic-regression model determinants including individual physician,...
Endocrine disrupting chemicals (EDCs) pose a public health risk through disruption of normal biological processes. Identifying toxicoepigenetic mechanisms developmental exposure-induced effects for EDCs, such as phthalates or bisphenol A (BPA), is essential. Here, we investigate whether maternal exposure to EDCs predictive infant DNA methylation at candidate gene regions. In the Michigan Mother-Infant Pairs (MMIP) cohort, was extracted from cord blood leukocytes analysis by pyrosequencing (n...
Abstract Objective The aims of this study were to determine if there is a relationship between middle cerebral artery (MCA) peak systolic velocity (PSV) and perinatal mortality in preterm intrauterine growth‐restricted (IUGR) fetuses, compare the performance MCA pulsatility index (PI), MCA‐PSV umbilical (UA) absent/reversed end‐diastolic (ARED) predicting mortality, longitudinal changes that occur MCA‐PI these test hypothesis can provide additional information on prognosis hypoxemic IUGR...
Objectives The purpose of this study was to determine whether a repeated antenatal ultrasound examination improves fetal cardiac visualization for the obese and nonobese population. Methods A computerized database (October 1999–June 2003) used identify singleton pregnancies undergoing prenatal examinations because initial suboptimal ultrasonographic (SUV) 4-chamber view, outflow tracts, or both. Women with maternal diabetes, abnormal serum screening results, known anomalies at were excluded....
Although fetal ultrasound, MRI and postnatal CT are now widely used in the evaluation of congenital lung malformations (CLM), their diagnostic accuracy remains undefined.To correlate prenatal imaging studies with pathological data after CLM resection.Retrospective, descriptive case series study.A North American tertiary care centre.One hundred three consecutive resections for a suspected between 1 January 2005 31 December 2015.Diagnostic diagnosis compared evaluation.Pathological diagnoses...
Exposures to endocrine disrupting chemicals and metals are near ubiquitous worldwide, their potential impact on children is a major public health concern. This pilot study was designed characterize exposures phthalates, phenols among pregnant women in the first trimester, examine associations with fetal biometrics birth weight. A total of 41 elements were analyzed urine from 56 mothers full-term newborns Michigan Mother-Infant Pairs study. Bivariate analyses identified predictors exposure...
Abstract The purpose of this study was to determine in what percentage cases the assessment placental localization using transabdominal sonography (TAS) changed after transvaginal (TVS) applied. TVS prospectively performed on all pregnant women at least 1.5 weeks' gestation, when edge TAS appeared be over or within 2 cm (low‐lying) internal cervical OS. time required for scan and distance from maternal OS were recorded. Of 168 patients entered into study, 131 analyzed. Landmarks poorly seen...
Preterm premature rupture of membranes (PROM) is associated with one-third preterm births. In about 50% PROM cases, the fetuses will elicit a fetal inflammatory response syndrome (FIRS). FIRS impending onset labor, periventricular leukomalacia, neonatal sepsis, and long-term handicap, including development bronchopulmonary dysplasia cerebral palsy. The myocardium potential target organ proinflammatory cytokines released during FIRS. objective this study was to determine whether functional...
Congenital airway obstruction poses a life-threatening challenge to the newborn. We present first case of three-dimensional (3D) modeling and 3D printing complex fetal maxillofacial anatomy after prenatal ultrasound indicated potential upper from midline mass maxilla. Using MRI patient-specific computer-aided modeling, craniofacial fetus was manufactured using printer. This model demonstrated be isolated lip maxilla, suggesting oral patent. The decision made deliver infant without planned ex...
Abstract Major alterations in metabolism occur during pregnancy enabling the mother to provide adequate nutrients support infant development, affecting birth weight (BW) and potentially long-term risk of obesity cardiometabolic disease. We classified dynamic changes maternal lipidome identified lipids associated with Fenton BW z-score umbilical cord blood (CB) lipidome. Lipidomics was performed on first trimester plasma (M1), delivery (M3), CB 106 mother-infant dyads. Shifts were consistent...
<b><i>Introduction:</i></b> A critical component of an evidence-based reassessment in-utero intervention for fetal aqueductal stenosis (fetal AS) is determining if the prenatal diagnosis can be accurately made at a gestational age amenable to intervention. <b><i>Methods:</i></b> multicenter, prospective, observational study was conducted through North American Fetal Therapy Network (NAFTNet). Pregnancies complicated by severe central nervous...