A5089743879- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Veterinary Oncology Research
- Ocular Surface and Contact Lens
- Connective tissue disorders research
- Cardiovascular Conditions and Treatments
- Microbial infections and disease research
- Biomedical Research and Pathophysiology
- Ocular Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Ocular Infections and Treatments
- Research on Leishmaniasis Studies
- Connexins and lens biology
- Retinal and Optic Conditions
- Gestational Trophoblastic Disease Studies
- Cardiovascular Issues in Pregnancy
- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Cervical Cancer and HPV Research
- Fermentation and Sensory Analysis
- Rabbits: Nutrition, Reproduction, Health
- Dysphagia Assessment and Management
- T-cell and Retrovirus Studies
- Ocular Diseases and Behçet’s Syndrome
University of California, Davis
2020-2025
Universidade do Porto
2020
Universitat Autònoma de Barcelona
2015-2017
Centre de Recerca en Sanitat Animal
2015
Abstract Purpose Corneal dysmorphologies (CDs) are typically classified as either regressive degenerative corneal dystrophies (CDtrs) or defective growth and differentiation-driven dysplasias (CDyps). Both eye disorders have multifactorial etiologies. While previous work has elucidated many aspects of CDs, such presenting symptoms, epidemiology, pathophysiology, the genetic mechanisms remain incompletely understood. The purpose this study was to analyze phenotype data from 8,707 knockout...
Although biomechanical changes of the trabecular meshwork (TM) are important to pathogenesis glucocorticoids-induced ocular hypertension (GC-OHT), there is a knowledge gap in underlying molecular mechanisms development it. In this study, we performed intravitreal triamcinolone injection (IVTA) one eye 3 rhesus macaques. Following IVTA, assessed TM stiffness using atomic force microscopy and investigated proteomic miRNA expression profiles. One macaques developed GC-OHT with difference...
Congenital Zika syndrome (CZS) is associated with microcephaly and various neurological, musculoskeletal, ocular abnormalities, but the long-term pathogenesis postnatal progression of defects in infants are not well characterized. Rhesus macaques superior to rodents as models CZS because they natural hosts virus share similar immune characteristics, including blood–retinal barrier characteristics unique presence a macula. Using previously described model CZS, we infected pregnant rhesus...
Foveoschisis involves the pathologic splitting of retinal layers at fovea, which may occur congenitally in X-linked retinoschisis (XLRS) or as an acquired complication myopia. XLRS is attributed to functional loss adhesion protein retinoschisin 1 (RS1), but pathophysiology myopic foveoschisis unclear due lack animal models. Here, we characterized a novel nonhuman primate model through clinical examination and multimodal imaging followed by morphologic, cellular, transcriptional profiling...
Domestic rabbits ( Oryctolagus cuniculus) are commonly kept as pets or bred for laboratory investigation, meat, fur production, a combination of these purposes. We conducted retrospective study to assess the prevalence diseases in domestic according purpose. retrieved results autopsies, biopsies, and cytologies from 2,583 cases received at 4 diagnostic laboratories California 2013–2022. Rabbits were classified (2,241; 86.8%), animals (92; 3.6%), meat-production (60; 2.3%), multipurpose (190;...
This study evaluated the tolerability and efficacy of topical rho-kinase inhibitor netarsudil for canine primary corneal endothelial degeneration (PCED). Twenty-six eyes 21 client-owned dogs with PCED were enrolled in a prospective, randomized, vehicle control clinical trial received 0.02% (Rhopressa®) or twice daily (BID) first 4 months. Then, all patients next 8 Complete ophthalmic examination, ultrasonic pachymetry, Fourier-domain optical coherence tomography, vivo confocal microscopy...
Abstract Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG most of canine breeds epidemiologically similar with older female patients overrepresented condition. American Cocker Spaniel (ACS) among common observed development This study initially sought identify genetic risk factors explain high prevalence ACSs by using case–control breed-matched genome-wide...
Objectives The aim of this study was to retrospectively evaluate the signalment, treatment, surgical technique and outcomes for feline symblepharon. Methods A retrospective medical record review standardized grading clinical descriptions photographs undertaken. Results Forty kittens (54 eyes) aged 3–46 weeks had symblepharon five types in various combinations: eyelid deformation (24 kittens; 32 eyes); ankyloblepharon (four four conjunctiva-to-conjunctiva (11 12 third eyelid-to-conjunctiva 29...
Abstract Background Imaging features obtained with Fourier-domain optical coherence tomography (FD-OCT) and in vivo confocal microscopy (IVCM) for corneal stromal disorders have been sparsely reported dogs. This case report is a compilation of imaging three cases different the canine cornea which not yet elsewhere. Case presentation Lipid deposition 1 appeared as needle-shaped hyperreflective lines along collagen lamellae, correlated histologically lipid clefts. In 2, glycosaminoglycan...
Purpose: The purpose of this study was to evaluate the tolerability and efficacy topical rho-kinase inhibitor ripasudil in treatment primary corneal endothelial degeneration (PCED) dogs. Methods: Twenty-one eyes 12 client-owned, PCED-affected dogs received 4 times daily. Ophthalmic examination, ultrasonic pachymetry (USP), Fourier-domain optical coherence tomography (FD-OCT), vivo confocal microscopy were performed at baseline 1, 3, 6, months. Effects on thickness, edema extent, cell density...
Purpose: To define the normal range of central corneal thickness (CCT) and endothelial cell density (ECD) in rhesus macaques (Macaca mulatta) effects age, body weight, sex, intraocular pressure (IOP) on these parameters. Methods: Ophthalmic examinations were performed 144 without anterior segment pathology. The CCT was measured via ultrasound pachymetry (USP) specular microscopy, ECD semiautomatically manually counted using microscopy. Rebound tonometry used to measure IOP. Linear regression...
Corneal wound healing is integral for resolution of corneal disease or post-operative healing. However, scarring that may occur secondary to this process can significantly impair vision. Tissue transglutaminase 2 (TGM2) inhibition has shown promising antifibrotic effects and thus holds promise prevent treat scarring. The commercially available ocular solution treatment manifestations Cystinosis, Cystaran®, contains the TGM2 inhibitor cysteamine hydrochloride (CH). purpose study assess safety...
Feline chronic enteropathy is a poorly defined condition of older cats that encompasses enteritis to low-grade intestinal lymphoma. The histological evaluation lymphocyte numbers and distribution in small biopsies crucial for classification grading. However, conventional methods quantification have low interobserver agreement, resulting diagnostic reliability. This study aimed develop validate an artificial intelligence (AI) model detect intraepithelial lamina propria lymphocytes hematoxylin...
To describe the clinical findings, multimodal corneal imaging features and treatment in canine patients diagnosed with endotheliitis.Four met inclusion criteria for bilateral disease endothelial inflammation secondary edema that responded to topical anti-inflammatory treatment.The selected underwent a complete ophthalmic examination emphasis on cornea including ultrasound pachymetry (USP), Fourier-domain optical coherence tomography (FD-OCT), vivo confocal microscopy (IVCM), digital slit...
To identify genetic associations with primary glaucoma (PG) in American Cocker Spaniels using a genome-wide association study (GWAS).A nationwide ambidirectional case-control cohort was performed that had an ophthalmic examination by veterinarian. Ninety-four dogs PG (cases) and 111 without (controls) met phenotypic criteria blood sample collected after receiving informed owner consent.Genomic DNA extracted from whole samples genotyped (CanineHD BeadChip, Illumina Inc). A GWAS linear mixed...
Abstract This report describes the clinical and histological findings, genetic study, treatment in a 1.3‐year‐old rhesus macaque with bilateral cataracts unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased intraocular pressure from 56 to <2 mm Hg. A putative cause was not identified.