A5014701433- Retinal Diseases and Treatments
- Gut microbiota and health
- Retinal Imaging and Analysis
- Viral gastroenteritis research and epidemiology
- Glaucoma and retinal disorders
- Connexins and lens biology
- Child Nutrition and Water Access
- Retinal Development and Disorders
- Dermatology and Skin Diseases
- Genetic and phenotypic traits in livestock
- RNA regulation and disease
- Infant Health and Development
- Cytomegalovirus and herpesvirus research
- Spinal Cord Injury Research
- Ocular Infections and Treatments
- Transcranial Magnetic Stimulation Studies
- Fish Ecology and Management Studies
- RNA Research and Splicing
- Genetics and Physical Performance
- Ophthalmology and Visual Impairment Studies
- RNA and protein synthesis mechanisms
- Veterinary Pharmacology and Anesthesia
- Infant Nutrition and Health
- Cellular transport and secretion
- Clostridium difficile and Clostridium perfringens research
University of California, Davis
2017-2024
The Ohio State University
2010-2012
Michigan State University
2003
Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 10,000 individuals, respectively. A major limitation to the development effective therapies is lack availability animal models that fully replicate human condition. Particularly for disorders, rodent, canine, feline no true macula have substantive limitations. By contrast, cone-rich nonhuman primate (NHP) closely mirrors retina....
Diarrhea is the second leading cause of death in children under 5 years age. Enhanced understanding causal pathways, pathogenesis, and sequelae diarrhea urgently needed. Although gut microbiota believed to play a role susceptibility diarrheal diseases, our this association remains incomplete. Infant rhesus macaques (Macaca mulatta) are susceptible making them an ideal model address question. The maturation infant macaque microbiome throughout first 8 months life occurs similar pattern as...
To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) histologic analysis.Enhanced-depth imaging-OCT images from 25 30 were evaluated for choriocapillaris choroidal-scleral junction (CSJ) visibility the central macula based on OCT reflectivity profiles, compared with age-matched sections. Semiautomated segmentation of CSJ was used to measure choriocapillary thickness, respectively. Multivariate...
Nonhuman primates are the only mammals to possess a true macula similar humans, and spontaneously develop drusenoid lesions which hallmarks of age-related macular degeneration (AMD). Prior studies demonstrated similarities between human nonhuman primate drusen based on clinical appearance histopathology. Here, we employed fundus photography, spectral domain optical coherence tomography (SD-OCT), autofluorescence (FAF), infrared reflectance (IR) characterize in aged rhesus macaques. Of 65...
Despite the impact of childhood diarrhea on morbidity and mortality, our understanding its sequelae has been significantly hampered by lack studies that examine samples across entire intestinal tract. Infant rhesus macaques are naturally susceptible to human enteric pathogens recapitulate hallmarks diarrheal disease such as inflammation growth faltering. Here, we examined biopsies, lamina propria leukocytes, luminal contents, fecal from healthy infants those experiencing faltering with...
Populations of wild lake trout Salvelinus namaycush have been extirpated from nearly all their historical habitats across the Great Lakes. Efforts to restore self-sustaining populations in U.S. waters emphasized stocking coded-wire-tagged juveniles six hatchery strains (Seneca Lake, Lewis Green Apostle Islands, Isle Royale, and Marquette) into vacant habitats. Strain-specific success has historically based on estimates survival catch rates adults returning spawning sites. However,...
Abstract Environmental enteric dysfunction is associated with malnutrition as well infant growth stunting and has been classically defined by villous blunting, decreased crypt-to-villus ratio, inflammation in the small intestine. Here, we characterized environmental among rhesus macaques that are naturally exposed to pathogens commonly linked human stunting. Remarkably, despite atrophy histological abnormalities observed intestine, poor trajectories low serum tryptophan levels were...
Lymphoproliferative disorders of natural killer (NK)-cell lineage are well documented in humans but have yet to be non-human primates (NHPs). Here we describe a case NK-cell lymphoproliferative disorder/leukemia 20-y-old captive female rhesus macaque ( Macaca mulatta). The animal clinically had mild splenomegaly and marked lymphocytosis with small-to-medium lymphocytes blood smears. By flow cytometry cluster differentiation, the were CD3-negative, CD8-positive, CD4-negative, CD20-negative...
Abstract A female rhesus macaque developed two episodes of generalized convulsions during transcutaneous spinal cord stimulation ( TSCS ) and urodynamic studies under ketamine anesthesia. The seizures took place in the absence active bladder pressure elevation. Ketamine anesthesia remains primary risk factor for these experimental procedures.
Treating and monitoring type 2 diabetes mellitus (T2DM) in NHP can be challenging. Multiple insulin hypoglycemic therapies management tools exist, but few studies demonstrate their benefits a clinical setting. The insulins glargine degludec are long-acting insulins; duration of action humans exceeds 24 42 h, respectively. In the first this study's components, we evaluated whether could dosed daily at equivalent units to achieve comparable blood glucose (BG) reduction diabetic rhesus macaques...
Abstract This report describes the clinical and histological findings, genetic study, treatment in a 1.3‐year‐old rhesus macaque with bilateral cataracts unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased intraocular pressure from 56 to <2 mm Hg. A putative cause was not identified.
Decreased appetite is a common clinical problem in captive rhesus macaques ( Macaca mulatta ). Mirtazapine, tetracyclic antidepressant originally developed for humans, has shown promise as safe and effective promoter of weight gain several veterinary species including cynomolgus macaques. Although mirtazapine available oral formulations, transdermal delivery with reduced would allow quick, painless, topical application. Here we describe the pharmacokinetics single application widely...
This report describes a spontaneous prostate fibromyxoid sarcoma with smooth muscle differentiation in an approximately 136-week-old intact male F344xBNF1 rat on diet study for 2 weeks. At necropsy, the was markedly distorted and enlarged by firm white multinodular mass (6.0 × 4.5 3.5 cm). Histopathologically, consisted of solid sheets interlacing mesenchymal spindle cells indistinct cell borders. Nuclei were separated variable amounts hyaline to fibrillar eosinophilic and/or myxomatous...