A5044136846- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Mast cells and histamine
- Dermatology and Skin Diseases
- Microbial infections and disease research
- Autoimmune Bullous Skin Diseases
- Retinoids in leukemia and cellular processes
- Oral and Maxillofacial Pathology
- Immunotoxicology and immune responses
- Psoriasis: Treatment and Pathogenesis
- Pesticide Exposure and Toxicity
- Hair Growth and Disorders
- Bird parasitology and diseases
- Turtle Biology and Conservation
- Nail Diseases and Treatments
- Veterinary Pharmacology and Anesthesia
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Infection Control and Ventilation
- Antimicrobial agents and applications
- Virus-based gene therapy research
- melanin and skin pigmentation
- Amphibian and Reptile Biology
- Biotin and Related Studies
- Contact Dermatitis and Allergies
Michigan State University
2018-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022
Freie Universität Berlin
2022
University of Bern
2022
University of Veterinary Medicine Vienna
2022
North Carolina State University
2022
Technische Hochschule Ingolstadt
2022
Roche (Switzerland)
2022
Ludwig-Maximilians-Universität München
2022
IDEXX Laboratories (Germany)
2022
Mitotic count (MC) is an important element for grading canine cutaneous mast cell tumors (ccMCTs) and determined in 10 consecutive high-power fields with the highest mitotic activity. However, there variability area selection between pathologists. In this study, MC distribution effect of on were analyzed ccMCTs. Two pathologists independently annotated all figures whole-slide images 28 ccMCTs (ground truth). Automated image analysis was used to examine ground truth throughout tumor section...
The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intraobserver discrepancies due to difficulties in selecting the region interest (MC-ROI) identifying or classifying figures (MFs). Recent progress field artificial intelligence allowed development high-performance algorithms that may improve standardization MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists ensure...
The majority of primary intestinal lymphomas in dogs are T-cell lymphomas, with enteropathy-associated lymphoma (EATL) large cell type (type 1) being the most common. While express marker CD3, there is increasing evidence that some human and canine coexpress B-cell CD20. We describe 3 cases CD3 + , CD20 Pax5 - EATL 1 dogs. All had clonal rearrangement receptor gamma. Initial clinical signs included weight loss, inappetence, diarrhea, and/or vomiting. mean age was 9 years (range 3–12)....
Canine oral malignant melanomas (OMMs) exhibit a variety of morphologic phenotypes, including spindloid variant. The microscopic diagnosis OMMs is based on junctional activity and/or the presence melanin pigment. In absence these features, are difficult to differentiate from soft tissue sarcomas (STS). An antibody cocktail (MDX) that includes Melan-A, PNL2, and tyrosinase-related proteins 1 2 (TRP-1 TRP-2) current gold standard for identifying amelanotic by immunohistochemistry (IHC)....
Summary An 11‐year‐old Trakehner gelding was presented for evaluation of lethargy, decreased appetite, mild icterus, and elevated hepatic enzyme activities. Physical examination, serum chemistry results, liver biopsy histopathologic findings were supportive Theiler's disease. Polymerase chain reaction ( PCR ) testing results tissue positive nonprimate (equine) hepacivirus NPHV a novel equine parvovirus‐hepatitis virus (Eq PV ‐H). the lot tetanus antitoxin administered to 3 months previously...
Canine nonepitheliotropic cutaneous T-cell lymphomas (NECTCL) are poorly characterized. In humans, a number of distinct subtypes NECTCL have been recognized, including subcutaneous panniculitis-like lymphoma (SPTCL). Five dogs with histologically similar to SPTCL in humans herein described. The mean age was 8.5 years (5.5 12 years). No breed or sex predilection identified this small cohort. Two presented an acute onset multiple skin masses and 3 had solitary subsequent development smaller...
Preparing the skin of rodents for surgery often involves multiple applications antiseptic agents. However, fewer may achieve same outcome. We evaluated antimicrobial efficacy and effects on intraoperative body temperature various surgical scrub agents, including novel waterless alcohol-based (WAB) options. Prior to ventral laparotomy, female C57BL/6 mice were treated with 0.9% saline (control); 70% ethanol; 10% povidone-iodine alternated or 2% chlorhexidine digluconate 1 3 WAB...
To evaluate the effect of a proprietary Manuka honey essential oil hydrogel on healing acute, full-thickness wounds in dogs.Prospective, controlled, randomized, experimental study.Purpose-bred, adult, female beagles (n = 10).Two 2 × cm surgical were created bilaterally trunk each dog; side was randomized to receive HoneyCure® (HOC) or standard-of-care (CON) dressings. Cranial for histopathological analysis and caudal culture planimetry. Total open wound areas measured with digital image...
Concurrent vasculopathic lesions in dogs with pemphigus foliaceus (PF) have been observed anecdotally yet not reported the literature. Any association prognosis is unclear.To compare clinical features and outcome of PF without lesions.Archived, formalin-fixed, paraffin-embedded biopsy samples 41 PF.Archived, a histological diagnosis were selected re-evaluated independently. Dogs assigned to groups following evaluation: Group 1 (no lesions) 2 (vasculopathic present). was subdivided into 2a...
A histopathologic study of free-ranging hummingbirds found in California, US was performed to identify mortality trends. Tissues from 61 wild representing five native California species collected by the San Diego Zoo 1996 2016 or Lindsay Wildlife Experience 2015 2017 were histologically examined. Birds either dead moribund at time submission euthanized due unresolvable health issues. Long-term rehabilitated birds excluded this study. Lesions sorted organ, etiology, and gender. The most...
<b>Abstract ID 101872</b> <b>Poster Board 214</b> Exposure to mustard vesicating, or blister, agents can lead severe and acute long-term injuries such as blistering, systemic toxicity, secondary infections, chronic inflammation. Sulfur (SM) exposure has caused long-lasting cutaneous respiratory complications in Iranian veterans of the Iran-Iraq War may be a contributing factor development Gulf Illness War. SM was first used weapon during World I (WWI) been number conflicts since, possibly...
Abstract Background Despite the common use of topical ophthalmic corticosteroids in dogs, detailed reports on systemic and dermatologic adverse effects are limited. Results Nine purpose-bred research Beagles were treated with difluprednate 0.05% emulsion one or both eyes 2–3 times daily. Some dogs developed mild to severe alopecia periocular region, face, distal pinna (5/9). The median duration treatment prior onset signs for was 550 days (453–1160 days). Diagnostic testing included complete...
Cairn terriers with ocular melanosis (OM) accumulate large, heavily pigmented melanocytes in the anterior uvea. Darkly plaques develop within sclera, leading us to hypothesize that OM uveal may have an abnormal migratory capacity.Globes from OM-affected and unaffected control eyes enucleated for reasons unrelated this study were used immunohistochemistry culture vitro cell behavior assays.The scleral of six dogs immunolabeled HMB-45, MelanA, PNL2, CD18, CD204, Iba-1 compared pigment cells...
Abstract Purpose The aim of this study was to describe normal ocular morphology and establish parameters for select diagnostics in a population Panamanian Golden Frogs ( PGF ) Atelopus zeteki maintained at the Detroit Zoo. Method A total 22 toads free disease were included study. Ophthalmic diagnostic tests as follows: endodontic absorbent paper point tear test EAPPTT ), assessment intraocular pressures IOP Rose Bengal stain, palpebral fissure width, blink rate corneal cultures. Histology...
A rapid increase in the global prevalence of skin inflammatory diseases like psoriasis cannot be attributed to genetics alone. Environmental factors including major ubiquitous organic pollutants polycyclic aromatic hydrocarbons (PAHs) could contribute their pathophysiology. Benzo[a]pyrene (BaP) is one PAH that generated mainly from cigarette smoke, wood‐burning, automobile exhaust etc. The molecular mechanisms lead following exposure BaP are not well elucidated, though there suggestions...
CASE DESCRIPTION A client-owned 2-year-old 1.8-kg (4-lb) male pet Rouen duck (Anas platyrhynchos domesticus) was evaluated because of severe swelling around the left eye following traumatic injury to upper and lower eyelids 2 associated surgeries that resulted in removal entire eyelid margins. CLINICAL FINDINGS At initial evaluation, ankyloblepharon observed, with no or margins a large, round, fluctuant subcutaneous mass over orbit. Orbital exploration histologic examination revealed benign...
Phosgene Oxime (dichloroform oxime; CX), an urticant or nettle agent categorized as a vesicant, is potential chemical threat agent. Its exposure causes rapid toxicity, severe pain with dermal symptoms including erythema (redness), urticaria, blanching, itching hives, necrosis and systemic effects. Due to its fast penetration, injury, instant lethal toxic effects resulting in high mortality, CX could be weaponized other agents enhance their deleterious Skin damage erythema, inflammation...
Abstract The mitotic count (MC) is an important histological parameter for prognostication of malignant neoplasms. However, it has inter- and intra-observer discrepancies due to difficulties in selecting the region interest (MC-ROI) identifying/classifying figures (MFs). Recent progress field artificial intelligence allowed development high-performance algorithms that may improve standardization MC. As algorithmic predictions are not flawless, computer-assisted review by pathologists ensure...
Emerging evidence suggests that environmental chemicals, mainly the organic pollutants like polycyclic hydrocarbons (PAHs), could contribute to pathophysiology of several chronic inflammatory skin diseases atopic dermatitis and psoriasis. Benzo[a]pyrene (BaP), main source atmospheric PAH, is generated from cigarette smoke, wood-burning automobile exhaust. Several reports suggest effects exerted by BaP be mediated via aryl hydrocarbon receptor (AhR) signaling pathway. AhR ligands exert...
Phosgene Oxime (CX) is a potent chemical warfare agent. It grouped with vesicants; however, its effect resembles of an urticant or nettle CX has faster penetration compared to other vesicating agents and causes erythema, urticaria, blanching, itching hives, necrosis, systemic toxic effects upon exposure. The mechanism induced toxicity not known there are no approved therapies. We have shown that dermal exposure in SKH-1 hairless mice clinical lesions, epidermal cell death, mast...
The purpose of this study was to investigate the antimicrobial efficacy a novel activated zinc solution against meticillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa after one hour, evaluate any untoward effect on local wound tissue at 24 hours exposure in pig model.A pathogen-free, commercially raised, Yorkshire-cross female acquired 12 days prior procedure. Within week procedure, small loopful test bacteria, (pig-isolate) MRSA (ATCC-6538), were streaked cultured...
Phosgene Oxime (dichloroform oxime; CX), an urticant classified as a vesicating agent, is potential chemical threat agent. With faster cutaneous penetration, corrosive properties, and more potent toxicity compared to other agents, CX causes immediate painful dermal systemic injuries. However, its mechanism of action not well studied. To explore the underlying CX-induced toxicity, we exposed dorsal skin SKH-1 hairless mice vapor for 0.5 or 1.0 min using two 12 mm caps. Our clinical findings...