A5041992853- Veterinary Oncology Research
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Animal Genetics and Reproduction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Human-Animal Interaction Studies
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- Microbial infections and disease research
- Genetic factors in colorectal cancer
- Veterinary Orthopedics and Neurology
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Global Cancer Incidence and Screening
- Air Quality and Health Impacts
- Odor and Emission Control Technologies
- Cancer survivorship and care
- Breast Cancer Treatment Studies
- Animal Behavior and Welfare Studies
- Childhood Cancer Survivors' Quality of Life
- Biomedical and Chemical Research
- Lipid metabolism and disorders
- Bone fractures and treatments
Morris Animal Foundation
2021-2025
Fred Hutch Cancer Center
2020-2022
Colorado State University
2016-2021
University of Washington
2020-2021
Emory University
2013
American Cancer Society
2012
Abstract In this study, we investigated age‐related changes in clinical laboratory data and their association with mortality dogs from the Golden Retriever Lifetime Study. By analyzing complete blood count (CBC) biochemistry 2′412 Retrievers over 16,678 visits, observed significant during first 2 years of life throughout aging. Based on these observations, developed a biological aging clock using LASSO model to predict age based markers, achieving an accuracy R = 0.78. Although pace did not...
Canine multicentric lymphoma (CML) is one of the most common malignancies in dogs. Although breed risk important, environmental factors such as herbicides have also been implicated. The objective this study was to determine whether genotoxic exposures 2,4-D and glyphosate are associated with CML, using dogs from Golden Retriever Lifetime Study cohort. We measured urinary concentrations golden retrievers CML matched unaffected controls at two time points: diagnosis 1 year prior diagnosis. To...
The aim of this article is to provide a detailed description the Golden Retriever Lifetime Study (GRLS), prospective cohort study investigating nutritional, environmental, lifestyle, and genetic risk factors for cancer other common diseases in dogs. Primary outcomes interest include hemangiosarcoma, lymphoma, osteosarcoma, high-grade mast cell tumors. Secondary cancers, hypothyroidism, epilepsy, atopy, otitis externa, hip dysplasia, heart failure, renal failure. A total 3,044 United States...
Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common haematopoietic malignancy in dogs. Recently, MYC and BCL2 expression levels determined with immunohistochemistry (IHC) were found to be prognostic people DLBCL. We hypothesized that canine DLBCL can similarly subdivided into subtypes based on of BCL2. Cases treated CHOP chemotherapy retrospectively collected 43 dogs had available histologic tissue complete clinical follow‐up. Median values percent immunoreactive versus...
Cherry eye is the common name for prolapse of nictitans gland, a tear-producing gland situated under third eyelid dogs. characterized by red fleshy protuberance in corner eye, resembling cherry. This protrusion displacement normal eyelid, thought to be caused defect connective tissue that secures place. Options treatment may include anti-inflammatory medications mild cases, but surgical replacement usually indicated. most often seen dogs age two years, with certain breeds having higher...
Abstract Background B‐cell chronic lymphocytic leukemia (BCLL) in dogs generally is considered an indolent disease, but previous studies indicate a wide range survival times. Objectives We hypothesized that BCLL has heterogeneous clinical course, similar to humans. aimed assess presentation and outcome with evaluate the prognostic relevance of flow cytometric factors. Animals One hundred twenty‐one diagnosed by cytometry. Three breed groups were represented: small (n = 55) because increased...
T-cell lymphomas (TCL) are a diverse group of neoplasms with variable diagnostic features, pathophysiologies, therapeutic responses and clinical outcomes. In dogs, TCL includes indolent aggressive tumours such as T-zone lymphoma (TZL) peripheral (PTCL), respectively. Delineation molecular subtypes investigation into underlying pathophysiologies TCLs remains inadequate. We investigate the correlations between flow cytometry histopathology 73 cases nodal TCL. The majority (82.2%) were...
Canine T‐zone lymphoma ( TZL ) is a subtype of T‐cell characterized by unique histologic pattern and cytomorphology, immunophenotypic loss CD45 expression, an indolent clinical behaviour. Dogs with typically present 1 or more enlarged lymph nodes and/or lymphocytosis. We describe novel extranodal presentation involving the tongue. Twelve dogs tongue masses were diagnosed lingual based on variable combination immunophenotyping via flow cytometry, cytology, histopathology, immunohistochemistry...
Identification of new genetic markers may improve the prediction colorectal cancer prognosis. Our objective was to examine genome-wide associations germline variants with disease-specific survival in an analysis 16,964 cases cancer. We analyzed genotype and cancer-specific data from a consortium 15 studies. Approximately 7.5 million SNPs were examined under log-additive model using Cox proportional hazards models, adjusting for clinical factors principal components. Additionally, we ran...
T zone lymphoma ( TZL ) is characterized by the clonal expansion of cells lacking expression pan‐leukocyte antigen CD45 TZ cells). A strong breed predisposition observed in Golden retrievers. This study aimed to confirm aberrant mRNA and determine if retrievers without clinical have an increased frequency circulating cells. Gene analysis on confirmed cases showed a significant decrease compared normal dogs. Peripheral blood samples from senior dogs, 242 42 non‐Golden retrievers, evidence...
Abstract Canine T‐cell lymphoma (TCL) encompasses a heterogeneous group of diseases with variable clinical presentation, cytomorphology, immunophenotype, and biologic behaviour. The most common types TCL in dogs involving peripheral lymph nodes include indolent T‐zone (TZL) biologically aggressive (PTCL). phenotypes can be categorized by expression the surface antigen molecules CD4 CD8. majority cases are + , far fewer being CD8 or − . features TCLs have been previously described. less...
T zone lymphoma (TZL), a histologic variant of peripheral cell lymphoma, represents about 12% all canine lymphomas. Golden Retrievers appear predisposed, representing over 40% TZL cases. Prior research found that asymptomatic aged frequently have populations zone-like cells (phenotypically identical to TZL) undetermined significance (TZUS), potentially pre-clinical state. These findings suggest genetic risk factor for this disease and caused us investigate potential genes interest using...
Postmenopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC heterogeneous disease, we evaluated whether the association of HT and differs across etiologically relevant, molecularly defined tumor subtypes location.
Abstract Background English bulldogs disproportionally develop an expansion of small B‐cells, which has been interpreted as B‐cell chronic lymphocytic leukemia (BCLL). However, clonality testing in these cases often not supportive neoplasia. Hypothesis have a syndrome nonneoplastic expansion. Animals Eighty‐four with small‐sized CD21 + lymphocytosis the blood determined by flow cytometry. Methods This is retrospective study. We characterized this assessing clonality, clinical presentation,...
Sleep quality in relation to anatomic site among colorectal cancer (CRC) patients is not well understood, though discerning the relationship could contribute improved survivorship care.We ascertained sleep (Pittsburgh Quality Index) and other personal characteristics within an ongoing population-based study of CRC identified through a registry (N = 1453). Differences by were analyzed using chi-square ANOVA tests. We used logistic regression estimate odds ratios (ORs) 95% confidence intervals...
Abstract Urothelial cell carcinoma (UCC) has been linked to environmental chemical exposures in people, but these risk factors are not well understood dogs with UCC. We hypothesised that household contribute the of UCC pet dogs. This prospective cross‐sectional case–control study included 37 and unaffected breed‐, sex‐, age‐matched controls. Dog owners completed an questionnaire samples were collected analysed for arsenic (in tap water room dust) acrolein air). Urine from dogs, control...
Lymphocytosis is relatively common in cats, but few studies describe lymphocyte populations or the clinical course associated with different immunophenotypic expansions.We hypothesized that cats frequently develop non-neoplastic lymphocytosis and neoplastic immunophenotypes have variable prognoses. We aimed to characterize expansions a large population of assess presentation outcome subset.Three cohorts older than 1 year (>6000/μL) were examined define categories (n = 146), evaluate 94),...
Abstract Background Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies, but current evidence on smoking association survival after CRC diagnosis is limited. Methods We pooled data from 12 345 patients stage I-IV 11 epidemiologic studies the International Survival Analysis Colorectal Cancer Consortium. Cox proportional hazards regression models were used to evaluate associations of prediagnostic behavior overall, CRC-specific, non-CRC-specific...
Background T‐zone lymphoma (TZL), an indolent disease in older dogs, comprises approximately 12% of lymphomas dogs. TZL cells exhibit activated phenotype, indicating the may be antigen‐driven. Prior research found that asymptomatic aged Golden Retrievers (GLDRs) commonly have populations T‐zone‐like (phenotypically identical to TZL) undetermined significance (TZUS). Objective To evaluate associations inflammatory conditions, and TZUS, using a case‐control study GLDRs. Animals cases (n =...
Lymphoma is the second most common cancer affecting Golden Retrievers and hypothesized to arise through a complex interaction of genetic environmental factors. The aim this nested case-control study was investigate association between potential pollutant sources lymphoma risk among participating in Retriever Lifetime Study. Forty-nine with non-cutaneous 98 without history matched by age, sex neuter status were selected from Study cohort. Geographic proximity each dog's primary residence nine...
Human chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease, and immunoglobulin heavy variable region (IGHV) gene mutational status an important prognostic marker. IGHV has not been previously examined in canine CLL. We sequenced the IGHV-D-J rearrangements from 55 patients with CLL, including 36 non-Boxer 19 Boxer dogs. The majority of non-Boxers (75%) had mutated genes, whereas Boxers (79%) unmutated genes. IGHV3-41 IGHV3-67 usage was significantly higher CLL compared to...