A5091670158- Veterinary Oncology Research
- Infectious Diseases and Mycology
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Virus-based gene therapy research
- Ethics and Legal Issues in Pediatric Healthcare
- Yersinia bacterium, plague, ectoparasites research
- Vector-borne infectious diseases
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Oropharyngeal Anatomy and Pathologies
- Cancer, Hypoxia, and Metabolism
- Zebrafish Biomedical Research Applications
- TGF-β signaling in diseases
- Neurofibromatosis and Schwannoma Cases
- High Altitude and Hypoxia
- Polyomavirus and related diseases
- Plant Stress Responses and Tolerance
- Medical Imaging Techniques and Applications
- Surgical Simulation and Training
- Cerebral Venous Sinus Thrombosis
- Cerebral Palsy and Movement Disorders
- Mesenchymal stem cell research
- HIV Research and Treatment
- T-cell and B-cell Immunology
Colorado State University
2017-2024
MedStar Washington Hospital Center
2023
MedStar Health
2023
Queen's Hospital
2022-2023
Queen's Medical Center
2022
University College London Hospitals NHS Foundation Trust
2022
National Hospital for Neurology and Neurosurgery
2022
University College London
2022
Queen's Hospital
2022
Colorado Department of Public Health and Environment
2019
The aim of this single case study was to determine the effectiveness a modified version constraint-induced movement therapy (mCIMT) on child less than one year age with diagnosis hemiplegic cerebral palsy. A single-subject ABAB design
T-cell lymphomas (TCL) are a diverse group of neoplasms with variable diagnostic features, pathophysiologies, therapeutic responses and clinical outcomes. In dogs, TCL includes indolent aggressive tumours such as T-zone lymphoma (TZL) peripheral (PTCL), respectively. Delineation molecular subtypes investigation into underlying pathophysiologies TCLs remains inadequate. We investigate the correlations between flow cytometry histopathology 73 cases nodal TCL. The majority (82.2%) were...
Canine T‐zone lymphoma ( TZL ) is a subtype of T‐cell characterized by unique histologic pattern and cytomorphology, immunophenotypic loss CD45 expression, an indolent clinical behaviour. Dogs with typically present 1 or more enlarged lymph nodes and/or lymphocytosis. We describe novel extranodal presentation involving the tongue. Twelve dogs tongue masses were diagnosed lingual based on variable combination immunophenotyping via flow cytometry, cytology, histopathology, immunohistochemistry...
Abstract Canine T‐cell lymphoma (TCL) encompasses a heterogeneous group of diseases with variable clinical presentation, cytomorphology, immunophenotype, and biologic behaviour. The most common types TCL in dogs involving peripheral lymph nodes include indolent T‐zone (TZL) biologically aggressive (PTCL). phenotypes can be categorized by expression the surface antigen molecules CD4 CD8. majority cases are + , far fewer being CD8 or − . features TCLs have been previously described. less...
The most common subtype of lymphoma in the dog is diffuse large B-cell (DLBCL). remaining forms dogs are categorized as small-to-intermediate size and include marginal zone, follicular, mantle cell, small-cell lymphocytic lymphoma. Marginal zone follicular have readily identifiable unique histologic features while other small poorly described by histopathology. Forty-seven cases nodal identified flow cytometry (small cell based on forward scatter) with concurrent histopathology were...
In December 2017, a dog that had pneumonic plague was brought to veterinary teaching hospital in northern Colorado, USA. Several factors, including signalment, season, imaging, and laboratory findings, contributed delayed diagnosis resulted potential exposure of >116 persons 46 concurrently hospitalized animals Yersinia pestis.
The wheat transcription factor TaABF1 physically interacts with the protein kinase PKABA1 and mediates both abscisic acid (ABA)-induced ABA-suppressed gene expression. In bombarded aleurone cells of imbibing grains, effect in down-regulating gibberellin (GA)-induced Amy32b promoter was stronger presence exogenous ABA. As these grains contained low levels endogenous ABA, may also be mediated by ABA-induced activation even absence Levels decreased slightly during imbibition afterripened...
Abstract Background Plague caused by Yersinia pestis is a highly infectious and potentially fatal zoonotic disease that can be spread wild domestic animals. In endemic areas of the northern hemisphere plague typically cycles from March to October, when flea vectors are active. Clinical forms include bubonic, septicemic, pneumonic plague. All clinical uncommon in dogs form exceedingly rare. Case presentation Two mixed breed young-adult male presented Colorado veterinarians with fever vague...
Abstract Background Peripheral T-cell lymphoma (PTCL) refers to a heterogenous group of neoplasms with poor treatment responses and survival times. Canine PTCL clinically immunophenotypically resembles the most common human subtype, PTCL-not otherwise specified (PTCL-NOS), leading interest in this canine disease as naturally occurring model for PTCL. Gene expression profiling PTCL-NOS has helped characterize ambiguous diagnosis into distinct subtypes, but similar gene is lacking. Methods...
Abstract Purpose Post-operative MRI is used to assess extent of resection, monitor treatment response and detect progression in high-grade glioma. However, compliance with accepted guidelines for follow-up MRI, impact on management/outcomes unclear. Methods Multi-center, retrospective observational cohort study patients confirmed WHO grade 4 glioma (August 2018-February 2019) receiving oncological treatment. Primary objective: investigate surveillance practice recommendations from NICE...
The occurrence of hyperostotic bilateral spheno-orbital meningiomas (BSOMs) is very rare. Patients present with symptoms and require treatment. This series describes 6 patients presenting to 2 UK neurosurgical units includes a literature review. To the best authors' knowledge, this largest documented.This retrospective review BSOMs between 2006 2023. Six females, whose mean age was 43 (range: 36-64) years, presented features visual disturbance. Bilateral sphen-oorbital were identified. All...
Background: The role played by the non-dominant parietal lobe in motor cognition, attention and spatial awareness networks has potentiated use of awake surgery. When this is not feasible, asleep monitoring mapping techniques should be used to achieve an onco-functional balance. Objective: This study aims assess feasibility a dual-strip method obtain direct cortical stimulation for continuous real-time subcortical visual pathways simultaneously tumour Methods: Single-centre prospective...
Abstract A 5‐year‐old, 0.92‐kg (2‐lb), spayed female Dwarf Hotot rabbit was evaluated for a 1‐day duration of lethargy and anorexia. Survey radiographs revealed evidence gastrointestinal stasis. Abdominal ultrasonography characterized multiple small, round, anechoic structures embedded in the mesentery. These were thin walled with hyperechoic strands/septations. Most contained well‐defined, eccentric, nodule adherent to intraluminal wall. Mesenteric cysticercosis confirmed via exploratory...
Abstract Pediatric low-grade glioma (pLGG) is the most common brain tumor in children. We and others have recently identified constitutive activation of mTOR MEK-pathway pLGG. This led us to investigate antitumor activity TAK228, a second generation mTORC1/2-inhibitor, FDA approved MEK-inhibitor, trametinib, mono- combination therapy examined five different patient-derived pLGG cell models treated with combination: JHH_NF1_PA1NF1mut, BT66_SV40BRAF:KIAA1549, BT40BRAFV600E, Res186PTEN-/-...
We report a case of 61-year-old lady presenting with several weeks progressive left-sided weakness, and found to have foramen magnum meningioma. She was counselled on surgical resection the tumour, preoperative computed tomography angiogram (CTA) obtained for operative planning purposes. CTA demonstrated incidental bilateral internal jugular vein (IJV) stenosis, enlarged extracranial collateral vessels elongated styloid processes. The main concern potential injury during exposure, which may...