A5083448400- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- 3D Printing in Biomedical Research
- DNA Repair Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Radiomics and Machine Learning in Medical Imaging
- Global Health and Surgery
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Diversity and Career in Medicine
- Radiation Dose and Imaging
- Cancer Genomics and Diagnostics
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Medical Imaging Techniques and Applications
- Ubiquitin and proteasome pathways
- Surgical site infection prevention
- Brain Metastases and Treatment
- Dental Education, Practice, Research
- RNA Research and Splicing
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Ultrasound in Clinical Applications
Sheffield Teaching Hospitals NHS Foundation Trust
2018-2025
University of Sheffield
2018-2025
Royal Hallamshire Hospital
2020-2025
University of Birmingham
2020-2021
Weston Park Cancer Centre
2020-2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
Molecular Oncology (United States)
2018-2021
Africa has the second highest neurosurgical workforce deficit globally and many medical students in lack exposure to field. This study aims assess impact of a rotation during school shaping perception interest toward career neurosurgery.Cross-sectional study.A Google form e-survey was disseminated African clinical between February 21st March 20th, 2021. Data on length of, in, neurosurgery were collected. analyzed using descriptive statistics adjusted logistic regression modeling.Data...
Cancer cells undergo morphological changes and phenotype switching to promote invasion into healthy tissues. Manipulating the transitional states in cancer prevent tumor dissemination may enhance survival improve treatment response. We describe two members of RhoGTPase activating protein (ARHGAP) family, ARHGAP12 ARHGAP29, as regulators glioma via Src kinase signaling events, leading that correspond switching. Moreover, we establish a link between glycogen synthase 3 (GSK-3) inhibition...
Developing and providing the right therapy for patient (or personalized targeted treatments) is key to reducing side-effects improving survival in childhood cancers. Most efforts aiming personalize cancer treatment use genomic analysis of malignancies identify potentially targetable genetic events. But it becoming clear that not all patients will have an actionable change, those do there no additional way determine if treatments be effective. Ex vivo drug screening a laboratory technique...
INTRODUCTION: Glioblastoma is the most common malignant primary brain tumor in adults. Post-operative MRI used to assess extent of resection, monitor treatment response and detect progression. However, compliance with accepted guidelines for follow-up MRI, impact on patient management outcomes unclear. METHODS: Multi-center, international, retrospective observational cohort study patients confirmed WHO grade 4 glioma (Operated August 2018-February 2019) receiving oncological treatment, May...
Objectives Pressures on healthcare systems due to COVID-19 has impacted patients without with surgery disproportionally affected. This study aims understand the impact initial management of brain tumours by measuring changes normal multidisciplinary team (MDT) decision making. Design A prospective survey performed in UK neurosurgical units from 23 March 2020 until 24 April 2020. Setting Regional outside London (as pandemic was more advanced at time study). Participants Representatives all...
Brain tumours kill more children and adults under 40 than any other cancer, with approximately half of primary brain being diagnosed as high-grade malignancies known glioblastomas. Despite de-bulking surgery combined chemo-/radiotherapy regimens, the mean survival for these patients is only around 15 months, less 10% surviving over 5 years. This dismal prognosis highlights urgent need to develop novel agents improve treatment tumours. To address this need, we carried out a human kinome siRNA...
With diminishing returns and high clinical failure rates from traditional preclinical animal-based drug discovery strategies, more emphasis is being placed on alternative platforms. Ex vivo approaches represent a departure both models clinical-based strategies aim to address intra-tumoural inter-patient variability at an earlier stage of discovery. Additionally, these could also offer precise treatment stratification for patients within week tumour resection in order direct tailored therapy....
Abstract Background High-grade gliomas are primary brain cancers with unacceptably low and persistent survival rates of 10–16 months for WHO grade 4 over the last 40 years, despite surgical resection DNA-damaging chemo-radiotherapy. More recently, tumour-treating fields therapy (TTFields) has demonstrated modest benefit been clinically approved in several countries. TTFields is thought to mediate anti-cancer activity by primarily disrupting mitosis. However, recent data suggest that may also...
Abstract Background The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of on decision making and resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors. Methods We performed a multicenter prospective study all adult discussed in weekly neuro-oncology skull base multidisciplinary team meetings who had (excluding pituitary) tumor between 01 April 31 May 2020. All at least 30-day follow-up data. Descriptive...
In this perspective, we congratulate the international efforts to highlight critical challenges in brain tumor research through a recent Consensus Statement. We also illustrate importance of developing more accurate and clinically relevant early translational vitro models—a perspective given limited emphasis Statement, despite models being widely used prioritize candidate therapeutic strategies prior vivo studies subsequent clinical trials. argue that successful translation effective novel...
Introduction Glioblastoma is the most common malignant primary brain tumour with a median overall survival of 12–15 months (range 6–17 months), even maximal treatment involving debulking neurosurgery and adjuvant concomitant chemoradiotherapy. The use postoperative imaging to detect progression high importance clinicians patients, but currently, optimal follow-up schedule yet be defined. It also unclear how adhering National Institute for Health Care Excellence (NICE) guidelines—which are...
Glioblastoma is an aggressive, incurable brain cancer with poor five-year survival rates of around 13% despite multimodal treatment surgery, DNA-damaging chemoradiotherapy and the recent addition Tumour Treating Fields (TTFields). As such, there urgent need to improve our current understanding cellular responses TTFields using more clinically surgically relevant models, which reflect profound spatial heterogeneity within glioblastoma, leverage these biological insights inform rational design...
<ns3:p>Background Glioblastoma is a highly infiltrative, currently incurable brain cancer. To date, translation of novel therapies for glioblastoma from the laboratory into clinical trials has relied heavily on <ns3:italic>in vitro</ns3:italic> cell culture and murine (subcutaneous orthotopic) xenograft models using cells derived main bulk patient tumours. However, it residual left-behind after surgery that are responsible disease progression death in clinic. A lack substantial improvements...
Colorectal cancer most often presents with a change in bowel habit, weight loss or bleeding per rectum. Much less commonly, colorectal may present as part of paraneoplastic syndrome. Polymyositis is rare disease considered complement-mediated idiopathic inflammatory myopathy manifested by proximal muscle weakness. However, polymyositis also be syndrome associated an underlying malignancy. The relationship between and malignancy well known, but it has been suggested that tumours the large are...
Delivering therapies to deeply seated brain tumours (BT) is a major clinical challenge.Magnetic drug targeting (MDT) could overcome this by rapidly transporting magnetised drugs directly into BT.We have developed magnetic device for application in murine BT models using an array of neodymium magnets with combined strength 0.7T.In closed fluidic system, the trapped nanoparticles (MNP) up distances 0.8cm.In mice, guided intravenously administered MNP (<50nm) from circulation where they...
Abstract Background Glioblastomas (GBM) have highly infiltrative growth patterns that contribute to recurrence and poor survival. Despite infiltration being a critical therapeutic target, no clinically useful therapies exist which counter GBM invasion. Here, we report inhibition of Ataxia telangiectasia Rad 3 related kinase (ATR) reduces invasion cells through dysregulation cytoskeletal networks subsequent integrin trafficking. Methods motility was assessed both in vitro vivo response ATR...
### What you need to know Nearly 35 000 children in the United Kingdom present emergency departments with head injuries each year.1 These are largely minor normal or minimally impaired consciousness level. Around 5% have intracranial complications approximately 1% having clinically important traumatic brain (box 1).12 Box 1 ### Definitions #### TBI-CT—Traumatic injury on CT2 Head any of following signs CT: #### ci-TBI — Clinically injury2 Traumatic resulting following:RETURN TO...