A 2-tiered histologic grading scheme for canine cutaneous mast cell tumors (MCTs) is based on morphologic characteristics of neoplastic cells, including karyomegaly, multinucleation, nuclear pleomorphism, and mitotic figures. Aspirates from MCTs may provide the same information more quickly, inexpensively, less invasively. This study used these criteria to develop a cytologic predict outcome. Three anatomic pathologists graded samples 152 MCTs. clinical evaluated aspirates masses using...

A 2-year-old spayed female Greater Swiss Mountain Dog was evaluated because of a 1-to 2-month history urinary incontinence and licking at the vulva.Treatment with phenylpropanolamine partially successful, but some remained.The only known surgical procedure dog had undergone ovariohysterectomy 6 months age. Clinical Gross FindingsPhysical examination revealed possible mass in caudal portion dog's abdomen.Important abnormalities were not detected via clinicopathologic analyses...

Marine turtle fibropapillomatosis (FP) is a debilitating, infectious neoplastic disease that has reached epizootic proportions in several tropical and subtropical populations of green turtles (Chelonia mydas). FP represents an important health concern sea rehabilitation facilities. The objectives this study were to describe the observed epidemiology, biology, survival rates affected by (FP turtles) environment; evaluate clinical parameters as predictors rehabilitating turtles; provide...

Abstract Canine lymphoma is a common spontaneous tumor with many similarities to human lymphoma, and thus has potential be an important animal model of lymphomagenesis. This study determined that microRNA (miRNA) expression in canine tumors can assessed using commercially available cancer miRNA qPCR array. six different lymphoid cell lines naturally occurring B‐ T‐cell lymphomas was compared RNA harvested from normal peripheral blood mononuclear cells (PBMC) lymph nodes (LN) as controls. We...

Background Anecdotal accounts and limited research suggest that dogs with spontaneous hyperadrenocorticism ( HAC ) are at risk of developing thromboembolic complications. Detailed description coagulation status identification subsets greatest would impact therapeutic recommendations for these patients. Hypothesis/Objectives Hypothesis: A subset will have a hypercoagulable tendency as identified by increased procoagulant activity, decreased fibrinolysis, or both. Objective 1: To document the...

Beta-gamma bridging (β-γ bridging) on serum protein electrophoresis is touted as being virtually pathognomonic for hepatic disease. However, the criteria β-γ are not defined, and few publications support a relationship between liver The goal of this retrospective study was to evaluate prevalence pathology in animals with bridging. All electrophoretograms from clinical patients generated at University Georgia 1994 2008 were evaluated presence bridging, defined (1) an albumin:globulin ratio...

Abstract Objective To establish a standard protocol for analysis of canine whole blood and generate reference intervals healthy dogs using the Sonoclot analyzer, to compare values viscoelastic coagulation tests. Design Prospective study. Setting Veterinary University research facility teaching hospital. Animals Twelve random source 52 from general veterinary school population. Interventions: Blood sampling testing. Measurements Main Results was collected 12 adult by jugular venipuncture....

Abstract Background Studies evaluating the potential impact of photographer experience or number images evaluated using “store‐and‐forward” method telecytology are not reported. Objectives This study aimed to determine diagnostic sensitivity (Se) and specificity (Sp) static when were taken by experienced inexperienced cytologists varied. Clinical agreement between diagnoses was compared. Methods Fifty archived cytology cases randomly chosen. A board‐certified clinical pathologist a recent...

Although neurological signs have been reported sporadically in dogs with systemic Lyme disease, it is unknown if neuroborreliosis occurs dogs. The current study systematically evaluates canine brains for evidence of Borrelia burgdorferi infection. Twelve Beagles were experimentally challenged B. burgdorferi–infected ticks at 18 weeks age, and 2 unexposed served as controls. One the uninfected 6 infected each given 5 daily immunosuppressive doses dexamethasone starting 153 days...

Four healthy adult dogs (Golden Retrievers aged 6 years and 9 years, Dalmatian 13 Mastiff 5 years) developed clinical signs of acute respiratory disease died within 2 to 7 days onset signs. The lungs the 3 submitted for necropsy were diffusely severely reddened due hyperemia hemorrhage. Microscopic lesions in all suggestive viral or toxic damage varied from severe fibrinonecrotic hemorrhagic bronchopneumonia fibrinous necrotizing bronchointerstitial pneumonia. Necropsied also had rhinitis...

The World Health Organization characterizes human choroid plexus tumor (CPT) as papilloma (CPP), atypical CPP (ACPP), and carcinoma (CPC). CPCs can disseminate via cerebrospinal fluid be mistaken for metastatic carcinoma, creating a diagnostic challenge. Kir7.1 immunohistochemistry (IHC) is highly reliable tool confirmation of CPTs their differentiation from carcinomas in beings dogs. This study describes the neuropathology, staining profile, immune cell population within microenvironment 11...

Abstract Case Description —A 5-year-old 38.3-kg (84.5-lb) mixed-breed dog was examined because of acute onset lethargy and anorexia. Four days later, a raised, firm, warm 15 × 10-cm lesion detected in the right caudal paralumbar area. Clinical Findings —Cephalexin treatment yielded poor response. Formalin-fixed tissue fluid samples from cystic areas were submitted for cytologic histologic examinations, routine bacterial mycobacterial culture, genus identification 16S partial sequencing via...

All male and female New Zealand white rabbits in a limbal cell graft study developed marked generalized mammary gland hypertrophy. Postprocedural medications included ophthalmic 0.1% dexamethasone, 0.5% cyclosporine, subcutaneous cyclosporine A. Cytologic examination revealed epithelial clusters with minimal malignant criteria. On histologic evaluation, there was diffuse glandular hyperplasia mild cellular atypia ductal ectasia separated by abundant hypercellular fibrous stroma, consistent...

This report describes the clinical and pathologic characteristics of cystic myxomatous lesions synovial joints in 16 cats. The average age was 13.4 years. elbow most commonly affected (12/16), all were unilateral. Degenerative joint disease a frequent concurrent but bilateral condition. consisted fluid-filled cysts lined by synoviocytes (3 cases), solid foci stellate cells matrix (2 or combination two (11 cases). In some cases there areas transition between lesions. Mitoses other features...

The cell count and differential of cerebrospinal fluid (CSF) cytologic examination classify CSF as inflammatory or not. cytospin yield is related to count, but our knowledge a relationship has not been characterized precision undocumented in any species. objective study was calculate intra-assay cellular on cytocentrifuged canine CSF, determine the factors that may affect precision, predict number cytospins necessary confirm mild neutrophilic pleocytosis. Ten concurrent replicate were...

Abstract Background Mycoleptodiscus indicus is a dematiaceous hyphomycete fungus found on plant leaves. It has been rarely reported as cause of human or animal disease, possibly because it difficult to culture and identify from clinical specimens. Infections are presumably acquired by traumatic implantation. Case presentation An 8-year-old non-immunosuppressed cat Georgia, USA, presented with left front leg swelling without lameness. Cytology fine needle aspirate revealed pyogranulomatous...

ABSTRACT Dry reagent strip evaluation of urine is a standard screening and diagnostic test used to assess overall health help detect or rule out specific disease conditions. A commercial at-home urinalysis kit using smartphone app evaluate free-catch being marketed directly dog cat owners. We compared agreement between simultaneous the reference methods in 48 canine urines submitted our referral laboratory. Agreement was defined by analyte based on clinical impact. Sensitivity, specificity,...

The study evaluated leukocyte esterase (LE) and nitrite reagent pad usefulness in canine urine using multiple time endpoints decision thresholds. Whole sedimented samples from 116 client-owned dogs were analyzed with strips four manufacturers. Results for LE recorded every 30 s up to 150 "trace" "+" positive thresholds compared microscopic sediment analysis culture results. Sedimented assessed at a threshold had significantly or trending higher sensitivity (brand dependent) pyuria detection...

Abstract OBJECTIVE To determine clinical signs, case fatality rate, and factors associated with positive results of PCR testing for canine influenza virus (CIV) in dogs during an H3N2 CIV outbreak the Atlanta area. DESIGN Cross-sectional study. ANIMALS 220 a nasal swab specimen submitted to Atlanta-area diagnostic laboratory between May 1 July 2, 2015, assay detection specifically or 5 other respiratory pathogens. PROCEDURES Veterinarians tested were surveyed by various means collect...

Blood smears from a 24-year-old male rhesus macaque ( Macaca mulatta) used for cognitive function studies were evaluated. The had an 8-month history of gradual weight loss and increasing lymphocytosis. Most the lymphocytes present small to medium mature morphology. Based on degree duration lymphocytosis, appearance lymphocytes, diagnosis chronic lymphocytic leukemia was made. animal tested negative 4 viral diseases that are commonly associated with lymphoproliferative disorders in Old World...