A5057852995- Veterinary Oncology Research
- Reproductive tract infections research
- Bacterial Infections and Vaccines
- Microbial infections and disease research
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Veterinary Equine Medical Research
- Respiratory viral infections research
- Reproductive System and Pregnancy
- Vector-Borne Animal Diseases
- Reproductive Physiology in Livestock
- Adolescent Sexual and Reproductive Health
- Tendon Structure and Treatment
- Environmental Toxicology and Ecotoxicology
- Toxoplasma gondii Research Studies
- Ear Surgery and Otitis Media
- Veterinary Pharmacology and Anesthesia
- Viral gastroenteritis research and epidemiology
- Aquaculture disease management and microbiota
- Viral Infections and Immunology Research
- Hedgehog Signaling Pathway Studies
- Cell death mechanisms and regulation
- Herpesvirus Infections and Treatments
- Vector-borne infectious diseases
- Ovarian function and disorders
University of Georgia
2015-2025
Georgia College & State University
2010-2022
Australia Zoo
2017
Australian Veterinary Association
2017
Taronga Conservation Society Australia
2017
UNSW Sydney
2017
Clearwater Christian College
2016
NOAA National Marine Fisheries Service
2016
Walsh College
2016
University of Florida
2016
ABSTRACT Nineteen natural cases of etiologically undetermined encephalitides in free-ranging cetaceans were studied retrospectively. Histological examination the brains revealed variable degrees nonsuppurative encephalitis or meningoencephalitis, characterized predominantly by perivascular lymphohistiocytic infiltrates. A PCR assay was used on brain and other available tissues to detect presence morbillivirus, herpesvirus, West Nile virus, Toxoplasma gondii , Brucella spp. In addition,...
The influenza neuraminidase (NA) is a promising target for next-generation vaccines. Protection induced by vaccination with the computationally optimized broadly reactive NA antigen (N1-I COBRA NA) was characterized in both serologically naive and pre-immune ferret models following H1N1 (A/California/07/2009, CA/09) or H5N1 (A/Vietnam/1203/2004, Viet/04) challenges. N1-I vaccine elicited antibodies neutralizing ELLA activity against seasonal pandemic influenza, as well virus. In models,...
Influenza A viruses cause severe morbidity and mortality during each influenza virus season. The emergence of SARS-CoV-2 infection in the human population offers opportunity to potential coinfections both viruses.
The pathogenesis and virulence of Bovine enterovirus-1 (BEV-1) in cattle is largely unknown. Reports concerning its suggest that there might be an association between BEV-1 infections a range diseases vary from respiratory to enteric reproductive disease infertility. In the current study, associated with acute infection calves experimentally inoculated Oklahoma isolate was described. Although interpretation study limited by lack effective control group, results inoculation BEV-1, virus...
Interleukin-10 (IL-10) has been implicated in susceptibility to genital chlamydial infection and the development of tubal pathologies. IL-10 limitation also resulted rapid elicitation immune responses against Chlamydia, decreased levels correlated with protective anti-Chlamydia immunity. To investigate molecular basis for these effects, we compared reproductive pathologies fertility rates Chlamydia-infected wild-type (WT) IL-10-knockout (IL-10(-/-)) mice; analyzed expression Toll-like...
Fibrosis is a pathological process with few therapeutic options. Experimental molecules are being developed to counteract the fibrotic effects through TGFβ receptor inhibition. Additionally, phosphodiesterase 5 (PDE5) inhibitors also have anti-fibrotic effects; however, mechanism of action remains unresolved. IPW5371 an example experimental TGFβ-mediated compound, and tadalafil PDE5 inhibitor. Irradiation increases frequency lesions, driven by activation pathway. We hypothesized that...
A juvenile offshore bottlenose dolphin (Tursiops truncatus) was found stranded with neurological signs and unable to swim or float unassisted. It subsequently died, succumbing a combination of severe pneumonia encephalitis. Morbillivirus serum neutralisation test serology positive (titre 1:16) for cetacean morbillivirus negative both phocine distemper virus canine virus. There concurrent thymic lymph node lymphoid depletion necrosis, together intranuclear intracytoplasmic acidophilic viral...
A recently deceased juvenile male bottlenose dolphin (Tursiops truncatus) was found floating in the Gulf of Mexico, off Sand Key Clearwater, Florida. At autopsy, we identified pneumonia and a focus malacia right cerebrum. Cytologic evaluation tissue imprints from cerebrum revealed fungal hyphae. Fungal cultures lung brain yielded Aspergillus fumigatus, which confirmed by amplification portion nuclear ribosomal internal transcribed spacer 2 region sequence. Microscopic pulmonary lesions...
Well-adapted pathogens must evade clearance by the host immune system and study of how they do this has revealed myriad complex strategies mechanisms. Classical bordetellae are very closely related subspecies that known to modulate adaptive immunity in a variety ways, permitting them either persist for life or repeatedly infect same host. Exploring hypothesis exposure cells would cause induce expression important immunomodulatory mechanisms, we identified putative regulator an pathway. The...
Infection and inflammation of the middle ears that characterizes acute chronic otitis media (OM), is a major reason for doctor visits antibiotic prescription, particularly among children. Nasopharyngeal pathogens are commonly associated with OM in humans do not naturally colonize rodents, experimental models most cases involve directly injecting large numbers human into ear bullae where they induce short-lived but fail to persist. Here we report Bordetella pseudohinzii, respiratory pathogen...
The brain from a 15-month-old, black female Angus, with 48-hour history of central nervous system disease, was submitted to the Oklahoma Animal Disease Diagnostic Laboratory. Microscopic findings consisted acute, multifocal meningoencephalitis, neuronal degeneration and necrosis gliosis. Viral isolation yielded noncytopathic bovine viral diarrhea virus (BVDV). Virus genotyping classified as BVDV type 2. Immunohistochemical labeling for antigens BVD MAb 3.12F1 clone prominent in cytoplasm...
One 2-year-old, 7.5 months pregnant Aberdeen Angus out of a herd 100 apparently healthy cows, died within 10 hours hospitalization. At necropsy, multiple foci mucosal hemorrhage and ulceration were observed in the spiral colon cecum. Virus isolation from intestinal lesions yielded cytopathic virus, which was revealed by electron microscopy to be an approximately 27 nm, nonenveloped virus. Further characterization reverse transcription-polymerase chain reaction (RT-PCR), sequencing 5′UTR...
Herpesviruses have been recognized in marine mammals, but their clinical relevance is not always easy to assess. A novel otarine herpesvirus-3 (OtHV3) was detected a geriatric California sea lion (Zalophus californianus), and using newly developed quantitative PCR assay paired with histology, OtHV3 associated esophageal ulcers B cell lymphoblastic lymphoma this animal. The prevalence quantities of were then determined among buffy coats from 87 stranded managed collection lions. Stranded...
In this study, we tested the hypothesis that rectal immunization with a VCG-based chlamydial vaccine would cross-protect mice against heterologous genital Chlamydia trachomatis infection and Chlamydia-induced upper tract pathologies in mice. Female were immunized C. serovar D-derived subunit or control live D elementary bodies (EBs) antigen-specific mucosal systemic immune responses characterized. Vaccine efficacy was determined by evaluating intensity duration of shedding following...
Genital C. trachomatis infection may cause pelvic inflammatory disease (PID) that can lead to tubal factor infertility (TFI). Understanding the pathogenesis of chlamydial complications including pathophysiological processes within female host genital tract is important in preventing adverse pathology. MicroRNAs regulate several infectious and non-infectious etiologies. In this study, we tested hypothesis miRNA profile single repeat infections will be different these differences time...
Recent findings revealed pivotal roles for eosinophils in protection against parasitic and viral infections, as well modulation of adaptive immune responses the gastric mucosa. However, known effects within respiratory tract remain predominantly pathological, associated with allergy asthma. Simulating natural infections mice, we examined how efficient well-adapted pathogens can block eosinophil functions that contribute to response. Bordetella bronchiseptica, a pathogen mouse, uses sigma...
Background Due to the technical difficulties with endotracheal intubation of rabbits, a prospective, randomised, controlled study was performed compare rabbit‐specific supraglottic airway device (SGAD), v‐gel, endoscopic (EEI) in spontaneously breathing rabbits undergoing ovariohysterectomy. Methods Fourteen adult female New Zealand white were randomly allocated one two groups based on method establishment: EEI or v‐gel SGAD. Anaesthesia induced ketamine and xylazine maintained using...
The increased susceptibility of neonates to specific pathogens has previously been attributed an underdeveloped immune system. More recent data suggest have effective protection against most but are particularly susceptible those that target functions neonates. Bordetella pertussis (Bp), the causative agent "whooping cough", causes more serious disease in infants its production toxin (PTx), although neonate-specific it targets remain unknown. Problematically, rapid development adult immunity...
Abstract Objective —To establish a safe and effective technique for the endoscopic examination biopsy of snake lungs by use 2.7-mm rigid endoscope system. Design —Clinical trial. Animals —17 adult ball pythons ( Python regius ). Procedures —The right lung each anesthetized was transcutaneously penetrated at predetermined site. Endoscopic objectively scored, 3 biopsies were performed. Tissue samples evaluated histologically diagnostic quality. One year later, 11 17 snakes again underwent...