A5010534530- Adipose Tissue and Metabolism
- Effects of Radiation Exposure
- Diet and metabolism studies
- Telomeres, Telomerase, and Senescence
- Gut microbiota and health
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Genetics, Aging, and Longevity in Model Organisms
- FOXO transcription factor regulation
- Preterm Birth and Chorioamnionitis
- MRI in cancer diagnosis
- Electromagnetic Fields and Biological Effects
- Ultrasound and Hyperthermia Applications
- Biochemical effects in animals
- Periodontal Regeneration and Treatments
- Advanced MRI Techniques and Applications
- Cholesterol and Lipid Metabolism
- Wound Healing and Treatments
- Muscle metabolism and nutrition
Wake Forest University
2019-2025
University of Massachusetts Chan Medical School
2008
Fibrosis is a pathological process with few therapeutic options. Experimental molecules are being developed to counteract the fibrotic effects through TGFβ receptor inhibition. Additionally, phosphodiesterase 5 (PDE5) inhibitors also have anti-fibrotic effects; however, mechanism of action remains unresolved. IPW5371 an example experimental TGFβ-mediated compound, and tadalafil PDE5 inhibitor. Irradiation increases frequency lesions, driven by activation pathway. We hypothesized that...
As the number of cancer survivors increases and risk accidental radiation exposure rises, there is a pressing need to characterize delayed effects develop medical countermeasures. Radiation has been shown damage adipose progenitor cells increase liver fibrosis, such that it predisposes patients developing metabolic-associated fatty disease (MAFLD) insulin resistance. The these conditions compounded by global rise diets rich in carbohydrates fats. persistently signaling cascade transforming...
Age-related changes in gut microbiome impact host health. The interactive relationship between the and physiological systems an aged body system remains to be clearly defined, particularly context of inflammation. Therefore, we aimed evaluate systemic inflammation, microbial translocation (MT), differences fecal mucosal microbiomes. Ascending colon biopsies, samples, blood samples from healthy young old female vervet monkeys were collected for 16S rRNA gene sequencing, MT, cytokine analyses,...
Type 2 diabetes (T2D) development may be mediated by skeletal muscle (SkM) function, which is responsible for >80% of circulating glucose uptake. The goals this study were to assess changes in global- and location-level gene expression, remodeling proteins, fibrosis, vascularity SkM with worsening glycemic control, through RNA sequencing, immunoblotting, immunostaining. We evaluated samples from health-diverse African green monkeys (Cholorcebus aethiops sabaeus) investigate these...
Abstract Recent evidence suggests that gut microbiome changes occur with age impact the health of host. While it is known and physiological systems interact, relationship between in an aged body system remains to be clearly defined, particularly context inflammation. Therefore, we aimed evaluate systemic inflammation mucosal young old female vervet monkeys. Ascending colon biopsies blood samples from healthy monkeys were collected for 16S rRNA gene sequencing cytokine analyses, respectively....
Abstract Amniotic fluid was collected from pregnant female African green monkeys (n = 20). Analyses indicate microbial translocation into amniotic during pregnancy is typical, and load reduces across gestation. Microbial does not relate to infant outcome or maternal factors. Lastly, we demonstrate that sample contamination easily introduced detectable.
Diabetic disease progression, resulting in diabetic kidney (DKD) increases the risk of failure and is a strong predictor for patient mortality. Early detection DKD could mitigate risks associated with but currently there are no well-established markers that serve this purpose. Healthy, insulin-resistant, non-human primates (vervets) were imaged using contrast enhanced ultrasound (CEUS) to quantify perfusion evaluate CEUS as an early method. Time-intensity curve (TIC) data generated by...
Abstract Ageing conveys the greatest risk for cardiovascular disease (CVD) development, which is dominant cause of mortality in developed nations. High density lipoprotein (HDL) particles mediate reverse cholesterol transport, are anti-inflammatory and their function predicts CVD. We observed lower plasma efflux capacity geriatric vervet monkeys (p=0.03) when consuming either healthy or Western diets. Adult (n=16) (n=19) were stratified into groups fed diet on ad libitum (Ad Lib) early time...
Abstract Context The trend to delay pregnancy in the United States has resulted number of advanced maternal age (AMA) pregnancies also increase. In humans, AMA is associated with a variety pregnancy-related pathologies such as preeclampsia (PE). While known be factor which contributes development pregnancy-induced diseases, molecular and cellular mechanisms giving rise this phenomenon are still very limited. This due part lack pre-clinical model physiologic relevance human while allowing...
The role of proteases in chronic wounds has been the subject many investigations recent years. These studies have reported biochemical differences between and acute wound fluids shown that elevated levels proteases, particular matrix metalloproteinases are abundant wounds. While this led to hypothesis environment is hostile not conducive repair, it still unknown whether due a direct or indirect defect protease regulation their inhibitors. We hypothesize an excess specifically serine present...