Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies diseases caused by several RNA viruses in people other species indicate that antiviral therapy may be effective against FIP The small molecule nucleoside analog GS-441524 molecular precursor to pharmacologically active triphosphate molecule. These analogs act as an alternative substrate RNA-chain terminator viral dependent polymerase. We determined was non-toxic feline cells...

Feline infectious peritonitis (FIP) is caused by a mutant biotype of the feline enteric coronavirus. The resulting FIP virus (FIPV) commonly causes central nervous system (CNS) and ocular pathology in cases noneffusive disease. Over 95% cats with will succumb to disease days months after diagnosis despite variety historically used treatments. Recently developed antiviral drugs have shown promise treatment nonneurological FIP, but data from neurological are limited. Four naturally occurring...

Feline infectious peritonitis (FIP) is a multisystemic, generally lethal immuno-inflammatory disease of domestic cats caused by an infection with genetic variant feline coronavirus, referred to as the FIP virus (FIPV). We leveraged data from four different antiviral clinical trials performed at University California, Davis. Collectively, total 60 client-owned cats, each confirmed diagnosis naturally occurring FIP, were treated variety compounds. The tested therapies included compounds...

Summary A 14‐year‐old Warmblood gelding presented for septic arthritis of the tarsocrural joint and tarsometatarsal post corticosteroid injection. Both joints were treated with arthroscopic needle lavage, respectively. Additional treatments included systemic antimicrobials, intravenous regional limb perfusions intra‐articular antimicrobials. Walking comfort significantly decreased 9 days lavage. Persistent synovial infection was confirmed through repeat arthrocentesis, necessitating a second...

Background Pancreatitis is a common disorder in dogs for which the antemortem diagnosis remains challenging. Objectives To compare sensitivity and specificity of serum markers pancreatitis with histopathologic evidence or lack thereof. Animals Seventy necropsied variety reasons pancreas was removed within 4 hours euthanasia serological were evaluated 24 death. Methods Prospective study: Serum analyzed amylase lipase activities, concentrations canine trypsin‐like immunoreactivity ( cTLI )...

During the development of antibacterial and antiviral materials for personal protective equipment (PPE), daylight active functional polymeric containing vitamin K compounds (VKs) impacts polymer structures to functions were investigated. As examples, hydrophobic polyacrylonitrile (PAN) hydrophilic poly(vinyl alcohol-co-ethylene) (PVA-co-PE) polymers directly blended with three VK electrospun into VK-containing nanofibrous membranes (VNFMs). The prepared VNFMs exhibited robust photoactivity...

Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and affordable vaccines or antiviral therapeutics. The has spectrum clinical presentations including an effusive (“wet”) form non-effusive (“dry”) form, both which may be complicated by neurologic ocular involvement. feline coronavirus (FCoV) biotype, termed virus (FIPV), the etiologic agent FIP. objective this study was to determine compare in vitro efficacies viral protease inhibitors GC376...

Summary Background Early and accurate detection of stress remodelling in racehorses is utmost importance to prevent catastrophic injuries. Current imaging techniques have limitations assessing early changes predisposing breakdowns. Positron emission tomography (PET) using 18 F‐sodium fluoride ( F‐NaF) a sensitive method for the bone turnover may improve recognition subtle Objectives To validate clinical use F‐NaF PET Thoroughbred racehorses, assess value lesions compare results with findings...

Nucleoside analogs GS-441524 and remdesivir (GS-5734) are effective in treating cats with feline infectious peritonitis (FIP). However, no studies have compared the efficacy between antiviral medications. The objective of this study was to evaluate orally administered GS-442514 (12.5–15 mg/kg) (25–30 a double-blinded non-inferiority trial. Eighteen effusive FIP were prospectively enrolled randomly assigned receive either or remdesivir. Cats treated daily for 12 weeks evaluated at week 0, 12,...

To identify risk factors associated with survival in dogs nontonsillar oral squamous cell carcinoma (OSCC) that were and not treated curative-intent surgery.Retrospective case series.31 OSCC.Medical records for OSCC treated, or surgery only between January 1990 December 2010 reviewed. For each dog, data regarding signalment, clinical stage, treatment, tumor recurrence, time obtained from the medical record, archived biopsy specimens evaluated to histologic subtype of extent tumor-associated...

Mesenchymal stem cells (MSCs) are a promising therapeutic option for various immune-mediated and inflammatory disorders due to their potent immunomodulatory trophic properties. Naturally occurring diseases in large animal species may serve as surrogate models of human disease, they better reflect the complex genetic, environmental, physiologic variation present outbred populations. We work with naturally understand how MSCs facilitate optimal translation MSC-based therapies. investigating...

In early 2003, an outbreak of malignant catarrhal fever (MCF) occurred in a bison feedlot southern Idaho. The resulted 51.2% (n = 825) mortality rate among bison, which had been exposed to sheep for 19 days. Diagnosis was made by detection ovine herpesvirus 2 (sheep-associated MCF virus) DNA tissues or peripheral blood polymerase chain reaction (PCR), and histological examination tissue lesions. Peak losses between 41 55 days postmean exposure time (PME), reached maximum head per day. No...

A multiorgan infection with a Coxiella-like organism was determined to be the cause of death female eclectus parrot( Eclectus roratus). The diagnosis based on gross lesions, histopathology, Gimenez and Gram special stains, immunohistochemistry, electron microscopy, polymerase chain reaction amplification sequencing bacterial 16s rRNA gene fragment isolated from hepatic cardiac tissue. Gross postmortem examination revealed multifocal coalescing foci necrosis. most significant histologic...

Canine distemper is a severe and lethal viral disease of dogs wild carnivores with an urgent need for the identification effective antiviral agents against canine virus (CDV). We assessed multiple their ability to block replication three different lineages CDV isolated from in United States. Six compounds were selected after preliminary experiments that excluded ribavirin, hesperidin rutin: protease inhibitor (nirmatrelvir), polymerase (favipiravir) four nucleoside analogs (remdesivir,...

SUMMARY Blood concentrations of thiamin, biotin, nicotinates, pantothenates, folates, riboflavin, vitamins A, B 6 , 12 C, E, β-carotene and choline were analyzed in healthy animals (23 horses, 25 dogs, 29 cats). B-Complex also the liver dogs cats. Vitamin blood livers similar; however, vitamin A lower cat than dog. Horses had a higher concentration did These data can be useful for detecting overt hidden deficits these species due to various conditions.