A5087062738- Electronic Health Records Systems
- Biomedical Text Mining and Ontologies
- Cancer Immunotherapy and Biomarkers
- Health Literacy and Information Accessibility
- Mobile Health and mHealth Applications
- Healthcare Technology and Patient Monitoring
- Health Sciences Research and Education
- CAR-T cell therapy research
- Technology Use by Older Adults
- Immunotherapy and Immune Responses
- Clinical Reasoning and Diagnostic Skills
- Patient Safety and Medication Errors
- Data Quality and Management
- HIV Research and Treatment
- Educational Games and Gamification
- Telemedicine and Telehealth Implementation
- Virus-based gene therapy research
- Healthcare Systems and Technology
- Online and Blended Learning
- Education and Critical Thinking Development
- Immune Cell Function and Interaction
- Semantic Web and Ontologies
- Innovations in Medical Education
- Misinformation and Its Impacts
- HIV/AIDS Research and Interventions
SUNY Downstate Health Sciences University
2020-2024
Simon Fraser University
2009-2021
Arizona State University
2011-2020
Gates Foundation
2018-2020
State University of New York
2020
Marymount University
2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2015-2018
Mayo Clinic
2018
Mayo Clinic in Florida
2018
Mayo Clinic Hospital
2016-2017
Programmed death-1–directed (PD-1–directed) immune checkpoint blockade results in durable antitumor activity many advanced malignancies. Recent studies suggest that IFN-γ is a critical driver of programmed death ligand-1 (PD-L1) expression cancer and host cells, baseline intratumoral T cell infiltration may improve response likelihood to anti–PD-1 therapies, including pembrolizumab. However, whether quantifying cell–inflamed microenvironment useful pan-tumor determinant PD-1–directed therapy...
Programmed cell death protein-1 (PD-1) and programmed ligand-1 (PD-L1) checkpoint blockade immunotherapy elicits durable antitumor effects in multiple cancers, yet not all patients respond. We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) a T cell-inflamed gene expression profile (GEP) exhibited joint predictive utility identifying responders nonresponders to PD-1 antibody pembrolizumab. TMB GEP were...
IL-33 is an IL-1 family member recently identified as the ligand for T1/ST2 (ST2), a of receptor family. ST2 stably expressed on mast cells and T(h)2 effector T its function has been studied in context T(h)2-associated inflammation. Indeed, induces cytokines from polarized mouse leads to pulmonary mucosal inflammation when administered vivo. To better understand how this pathway modulates inflammatory responses, we examined activity variety human immune cells. Human blood-derived basophils...
The effects of many protease inhibitor (PI)-selected mutations on the susceptibility to individual PIs are unknown. We analyzed in vitro test results 2,725 HIV-1 isolates. More than 2,400 isolates had been tested for fosamprenavir, indinavir, nelfinavir, and saquinavir; 2,130 lopinavir; 1,644 atazanavir; 1,265 tipranavir; 642 darunavir. applied least-angle regression (LARS) 200 most common data set identified a 46 associated with decreased PI which 40 were not polymorphic eight group M...
Background: Consumer eHealth interventions are of a growing importance in the individual management health and behaviors. However, range access, resources, skills barriers prevent care consumers from fully engaging benefiting spectrum interventions. Consumers may engage tasks, such as participating discussion forums entering information into personal record. literacy names set knowledge that essential for productive interactions with technology-based tools, proficiency retrieval strategies,...
Chronic diseases, endemic in the rapidly aging population, are stretching capacity of healthcare resources. Increasingly, individuals need to adopt proactive health attitudes and contribute management their own health. We investigate existing diabetes self-management practices ways which reflection on prior actions impacts future lifestyle choices. The findings suggest that generate evaluate hypotheses regarding implications actions. Thus, health-monitoring applications can assist making...
Despite the proliferation of consumer health sites, lay individuals often experience difficulty finding information online. The present study attempts to understand users' seeking difficulties by drawing on a hypothesis testing explanatory framework. It also addresses role user competencies and their interaction with internet resources.Twenty participants were interviewed about understanding hypothetical scenario family member suffering from stable angina then searched MedlinePlus portal for...
Mobile phones and tablets currently represent a significant presence in people's everyday lives. They enable access to different information services independent of current place time. Such widespread connectivity offers potential app areas including health care.Our goal was evaluate the usability Connect app. The mobile enables system, an online system that supports cancer patients managing health-related issues. Along with symptom management, promotes better patient-provider communication,...
9568 Background: T-VEC is a herpes simplex virus (HSV)-1 -based oncolytic immunotherapy designed to selectively replicate in tumors, produce GM-CSF and stimulate antitumor immune responses melanoma. significantly improved durable response rate vs stage IIIB-IV melanoma patients (pts) with injectable tumors. Pembro inhibits programmed cell death protein 1 improves survival advanced The combination may further improve clinical benefit. Here we report phase 1b efficacy, safety biomarker data...
Critical evaluation of online health information has always been central to consumer informatics. However, with the emergence new Web media platforms and ubiquity social media, issue taken on a dimension urgency. At same time, many established existing quality guidelines address characteristics other than content (eg, authority currency), target creators rather users as their main audience, or do not presented via novel technologies.The aim this formative study was (1) develop methodological...
Because scientific research is guided by concerns for uncovering "fundamental truths," its time frame differs from that of design, development, and practice, which are driven immediate needs practical solutions. In medicine, however, as in other disciplines, basic scientists, developers, practitioners being called on increasingly to forge new alliances work toward common goals. The authors propose medical informatics be construed a local science design. A seeks explain aspects domain rather...
Meeting abstracts Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolizing enzyme that expressed in many cancers and induces immune tolerance by suppressing T cell responses. Epacadostat potent, selective oral inhibitor of IDO1. A dose-escalation study epacadostat with
ABSTRACT The innate immune pathways that contribute to the potent immunogenicity of recombinant adenovirus (rAd) vaccine vectors remain largely undefined. Previous studies assessing immunity triggered by have focused on in vitro involving antigen-presenting cells and early vivo inflammatory responses. Here, we systematically explore Toll-like receptor (TLR) signaling requirements for generation cellular responses intramuscular immunization with common alternative serotype rAd mice....
Plus disease is the most important parameter that characterizes severe treatment-requiring retinopathy of prematurity, yet diagnostic agreement among experts imperfect and precise factors involved in clinical diagnosis are unclear. This study designed to address these gaps knowledge by analyzing cognitive aspects plus process experts.To examine reasoning for prematurity using qualitative research techniques.Cognitive walk-through, with analysis videotaped expert responses quantitative...