A5043721847- Ovarian function and disorders
- Hypothalamic control of reproductive hormones
- Diabetes Management and Research
- Reproductive Biology and Fertility
- Thyroid Cancer Diagnosis and Treatment
- Growth Hormone and Insulin-like Growth Factors
- Estrogen and related hormone effects
- Trauma and Emergency Care Studies
- Diabetes Management and Education
- Childhood Cancer Survivors' Quality of Life
- Economic and Environmental Valuation
- Health Systems, Economic Evaluations, Quality of Life
- BRCA gene mutations in cancer
- Medication Adherence and Compliance
- Chronic Disease Management Strategies
- Menopause: Health Impacts and Treatments
- Diabetes Treatment and Management
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Genetics and Neurodevelopmental Disorders
- Pancreatic and Hepatic Oncology Research
- Child and Adolescent Health
- Adolescent and Pediatric Healthcare
- Cancer Risks and Factors
- Cancer Cells and Metastasis
University of British Columbia
2013-2025
Dayanand Medical College & Hospital
2025
St. Paul's Hospital
2005-2023
British Columbia Children's Hospital
2012-2023
Florida International University
2021
Regional Medical Center
2020-2021
University of South Florida
2021
University of New Mexico
2021
St. Paul's Hospital
2016-2020
Hauptman-Woodward Medical Research Institute
2012-2016
Context: Patients with polycystic ovarian syndrome (PCOS) have increased LH relative to FSH, but is modified by body mass index (BMI). Objective: The objective of the study was determine whether impact BMI on neuroendocrine dysregulation in PCOS mediated at hypothalamic or pituitary level. Participants/Interventions/Setting: Twenty-four women across a spectrum BMIs underwent frequent blood sampling, iv administration GnRH (75 ng/kg), and sc NAL-GLU antagonist (5 μg/kg) General Clinical...
Studies of the effects gonadal steroid negative feedback and age on hypothalamic-pituitary axis in postmenopausal women (PMW) have identified significant but inconsistent changes gonadotropin dynamics. In current study, we investigated effect replacement overall GnRH secretion estimated by using submaximal receptor blockade. Twenty-four healthy PMW, 45–55 yr (n = 13) 70–80 11), were studied. Subjects studied at baseline (BL) no hormone therapy, after 1 month transdermal estrogen (50 μg/d; E)...
Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. Despite initial responsiveness, 80% of EOC patients recur and present with chemoresistant a more aggressive disease. This suggests an underlying biology that results in modified recurrent disease, which distinct from primary tumor. Unfortunately, management similar to disease does not parallel molecular changes may have occurred during process rebuilding We describe characterization unique vitro vivo models study...
There is now evidence for alterations in the neuroendocrine control of reproductive axis with aging, but its sensitivity to gonadal steroid negative feedback remains controversial. To examine independent effect age and feedback, younger (45–55 yr; n = 7) older (70–80 6) postmenopausal women (PMW) were studied at baseline on no HRT, after 1 month transdermal estrogen (50 μg/d; E) again a further E 7 d transvaginal progesterone (P) (100 mg bid; + P). At each admission, blood was sampled every...
Objectives: The aim of this study was to determine the insulin-delivery system and attributes insulin therapy that best meet patients' preferences, estimate willingness-to-pay (WTP) for them. Methods: This a cross-sectional discrete choice experiment (DCE) involving 378 Canadian patients with type 1 or 2 diabetes. Patients were asked choose between two hypothetical treatment options made up different combinations attribute levels. Regression coefficients derived using conditional logit...
To evaluate patients' preferences for various attributes of insulin treatment, including route delivery.We used a discrete choice experiment (DCE) to quantify preferences. The (and levels) included in the DCE questionnaire were: glucose control, frequency hypoglycemic events, weight gain, administration long-acting and short-acting insulin, out-of-pocket cost. Data were analyzed using conditional logit regression segmented models also developed differences between subgroups.Two hundred...
Digital health programs may have the potential to prevent hospitalizations among patients with chronic diseases by supporting patient self-management, symptom monitoring, and coordinated care.To compare effect of an internet-based self-management monitoring program targeted 2 or more (internet disease management [CDM]) usual care on over a 2-year period.This single-blinded randomized clinical trial included multiple from 71 primary clinics in small urban rural areas throughout British...
Background: An evaluation of patients' preferences is necessary to understand the demand for different insulin delivery systems. The aim this study was investigate association between socioeconomic status (SES) and willingness pay (WTP) various attributes administration diabetes management. Methods: We conducted a discrete choice experiment (DCE) determine patients` their WTP hypothetical treatments. Both self-reported annual household income education completed were used explore differences...
Abstract A common property of Cu/Zn superoxide dismutase 1 ( SOD 1), harboring mutations associated with amyotrophic lateral sclerosis, is a high propensity to misfold and form abnormal aggregates. The aggregation mutant has been demonstrated in vitro , purified proteins, mouse models, human tissues, cultured cell models. In translation studies have determined that sclerosis slower mature, thus perhaps vulnerable off‐pathway folding could generate living cells can be monitored by tagging the...
Management of recurrent differentiated thyroid cancer (DTC) may include surgery, radioactive iodine (RAI), and external beam radiotherapy (EBRT). Systemic therapy also be offered for RAI-refractory DTC. The study objective was to review patterns practice in British Columbia (BC) treatment DTC, assess rates disease, evaluate outcomes.BC Cancer provides care a population 4.6 million. A retrospective all patients with DTC stage I-IVB disease referred BC from 2009 2013 conducted. Patient...
Objective: To explore which attributes of insulin therapy drive patients' preferences for management in Canada and Brazil. Methods: A qualitative design was implemented a total 32 patients with type 2 diabetes from Brazil, were interviewed one the 4 focus groups, or 16 individual interviews. Eighteen participants (56%) women fourteen (44%) men (15 nonusers 17 users). Two groups each 9 interviews conducted In Canada, 7 conducted. framework analysis used to analyse all data. Results: Brazilian...
There is dramatic slowing of GnRH pulse frequency during sleep in the early follicular phase menstrual cycle, but it unknown whether this represents a primary effect or dependent upon sex steroid environment.
Grp94 and Hsp90 are the ER cytoplasmic paralog members, respectively, of hsp90 family molecular chaperones. The structural biochemical differences between that allow each to efficiently chaperone its particular set clients poorly understood. two paralogs exhibit a high degree sequence similarity, yet also display significant in their quaternary conformations ATPase activity. In order identify elements distinguish from Hsp90, we characterized similarities proteins by testing ability...