Jure Murgić
A5063690225- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Advanced Radiotherapy Techniques
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Healthcare professionals’ stress and burnout
- Multiple and Secondary Primary Cancers
- Cancer survivorship and care
- Thyroid Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Heterotopic Ossification and Related Conditions
- Thyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
Sisters of Charity Hospital
2012-2024
Catholic University of Croatia
2024
University Hospital Centre Zagreb
2011-2023
University of Zagreb
2012-2023
Princess Margaret Cancer Centre
2015-2022
University of Toronto
2015-2020
University Health Network
2016-2020
Sunnybrook Health Science Centre
2017-2019
Health Sciences Centre
2019
University of Michigan
2012-2014
Background Immune checkpoint inhibitors (ICIs) represent an appealing treatment for patients with advanced urothelial cancer (aUC) and a poor performance status (PS). However, the benefit of ICIs PS remains unknown. It was hypothesized that Eastern Cooperative Oncology Group (ECOG) (≥2 vs 0‐1) would correlate shorter overall survival (OS) in receiving ICIs. Methods In this retrospective cohort study, clinicopathologic, treatment, outcome data were collected aUC who treated at 18 institutions...
The study aimed at identifying patient-specific dosimetric and nondosimetric factors predicting outcome of non-Hodgkin lymphoma patients after <sup>131</sup>I-tositumomab radioimmunotherapy for potential use in treatment planning. <b>Methods:</b> Tumor-absorbed dose measures were estimated 130 tumors 39 relapsed or refractory by coupling SPECT/CT imaging with the Dose Planning Method (DPM) Monte Carlo code. Equivalent biologic effect was calculated to assess effects nonuniform absorbed...
Urinary tract cancer can be pure urothelial carcinoma, nonurothelial carcinoma or variant (defined here as mixed carcinoma). Little is known regarding outcomes for patients with receiving immune checkpoint inhibitors. We hypothesized that does not compromise inhibitor efficacy in advanced carcinoma.We performed a retrospective cohort study across 18 institutions. Demographic, clinicopathological, treatment and data were collected who received Patients divided into vs subgroups, further by...
The National Comprehensive Cancer Network (NCCN) has recently endorsed the stratification of intermediate-risk prostate cancer (IR-PCa) into favorable and unfavorable subgroups recommend addition androgen deprivation therapy (ADT) to radiation (RT) for IR-PCa. Recently, more accurate prognostication was demonstrated by integrating a 22-feature genomic classifier (GC) NCCN system. Here, we test utility GC better identify patients with IR-PCa who are sufficiently treated RT alone.We identified...
Objectives To compare clinical outcomes between patients with locally advanced (unresectable) or metastatic urothelial carcinoma (aUC) in the upper and lower urinary tract receiving immune checkpoint inhibitors (ICIs). Patients Methods We performed a retrospective cohort study collecting clinicopathological, treatment, outcome data for aUC ICIs from 2013 to 2020 across 24 institutions. compared objective response rate (ORR), overall survival (OS), progression‐free (PFS) UC (UTUC, LTUC). Uni‐...
The aberrant overexpression of alpha satellite DNA is characteristic many human cancers including prostate cancer; however, it not known whether the change in RNA amount occurs peripheral tissues cancer patients, such as blood. Here, we analyse level intracellular whole blood patients at different stages disease and compare with levels found healthy controls. Our results reveal a significantly increased metastatic particularly those castration-resistant relative to In localised tumour, no...
PURPOSE: Burnout is defined as a three-dimensional syndrome—emotional exhaustion (EE), depersonalization (DP), and reduced personal accomplishment (PA)—caused by chronic occupational stress. The aim of the current study was to investigate prevalence burnout among oncologists in Eastern Europe identify contributing factors. METHODS: conducted an online survey between October 2017 March 2018. Oncologists (including medical, radiation, clinical, surgical oncologists) from 19 countries were...
Objectives: The objective of the study was to investigate prostate-specific antigen (PSA) nadir (nPSA) and time nPSA (TnPSA) as prognostic variables for outcomes after definitive high-dose (>75 Gy) external beam radiation therapy (RT) without androgen deprivation while correcting immortal-time bias. Methods: TnPSA were available 410 patients. TnPSA’s impact on freedom from biochemical failure, metastasis, prostate cancer–specific survival assessed univariate multivariate analysis using...
The choice of therapy for muscle-invasive bladder cancer (MIBC) could be influenced by the tumor’s molecular subtype. Currently, well-defined consensus subtypes are based on tumor microarray mRNA data. Clearly defined and easy-to-use surrogate subtypes, immunohistochemistry (IHC) performed whole slides, needed to make subtyping cost-effective useful in routine work future research. To aid development a simple immunohistochemical classifier, retrospective single-center series 92 cases...
To address the challenge of finding new combination therapies against castration-sensitive prostate cancer, we introduce Vini, a computational tool that predicts efficacy drug combinations at intracellular level by integrating data from KEGG, DrugBank, Pubchem, Protein Data Bank, Uniprot, NCI-60 and COSMIC databases. Vini is drugs their level. It addresses problem comprehensively considering all known target genes, proteins small molecules mutual interactions involved in onset development...