A5046404259- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- Statistical Methods in Clinical Trials
- Cancer, Lipids, and Metabolism
- Genital Health and Disease
- AI in cancer detection
- Neonatal and fetal brain pathology
- Urinary Bladder and Prostate Research
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
- Fetal and Pediatric Neurological Disorders
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Health Systems, Economic Evaluations, Quality of Life
- Renal and Vascular Pathologies
- Advanced X-ray Imaging Techniques
- Neonatal Respiratory Health Research
- Medical Imaging and Analysis
- Protease and Inhibitor Mechanisms
- Clinical practice guidelines implementation
- Reconstructive Surgery and Microvascular Techniques
- Hemodynamic Monitoring and Therapy
- Advanced Neuroimaging Techniques and Applications
Maasstad Ziekenhuis
2020-2024
Erasmus MC Cancer Institute
2014-2022
The Prostate Centre
2022
Erasmus MC
2014-2020
University Health Network
2020
Erasmus University Rotterdam
2010-2020
University of Tennessee Health Science Center
2019
Meertens Institute
2017
Codarts Rotterdam
2016
Bloomberg (United States)
2014
Five years after the last prostatic carcinoma grading consensus conference of International Society Urological Pathology (ISUP), accrual new data and modification clinical practice require an update current pathologic guidelines. This manuscript summarizes proceedings ISUP meeting for held in September 2019, Nice, France. Topics brought to included following: (1) approaches reporting Gleason patterns 4 5 quantities, minor/tertiary patterns, (2) agreement report presence invasive cribriform...
Invasive cribriform and intraductal carcinoma in radical prostatectomy specimens have been associated with an adverse clinical outcome. Our objective was to determine the prognostic value of invasive pre-treatment biopsies on time disease-specific death. We pathologically revised diagnostic 1031 patients from first screening round European Randomized Study Screening for Prostate Cancer (1993–2000). Ninety percent all (n=923) had received active treatment, whereas 10% (n=108) followed by...
Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with adverse outcome of prostate cancer patients. The aim this study was to determine the molecular aberrations CR/IDC in primary cancer, focusing on genomic instability somatic copy number alterations (CNA). Whole-slide images Cancer Genome Atlas Project (TCGA, N = 260) Canadian Prostate Network (CPC-GENE, 199) radical prostatectomy datasets were reviewed for Gleason score (GS) presence CR/IDC. Genomic assessed by...
To assess the interobserver reproducibility of individual Gleason grade 4 growth patterns.Twenty-three genitourinary pathologists participated in evaluation 60 selected high-magnification photographs. The selection included 10 cases 3, 40 (10 per pattern), and 5. Participants were asked to select a single predominant case (3, 4, or 5), indicate pattern, if present. 'Consensus' was defined as at least 80% agreement, 'favoured' 60-80% agreement. Consensus on grading reached 47 (78%) cases, 35...
Microscopic evaluation of prostate specimens for both clinical and research purposes is generally performed on 5-μm-thick tissue sections. Because cross-sections give a two-dimensional (2D) representation, little known about the actual underlying three-dimensional (3D) architectural features benign cancer (PCa). The aim this study was to show that combination tissue-clearing protocols confocal microscopy can successfully be applied investigate 3D architecture human tissue.Optical clearing...
Nerve-sparing (NS) radical prostatectomy (RP) results in better functional outcomes. Intraoperative neurovascular structure-adjacent frozen section examination (NeuroSAFE) significantly increases the frequency of NS surgery. The effect NeuroSAFE on postoperative erectile function (EF) and continence is not yet clear.
Objectives To assess the metastasis‐free survival ( MFS ) and disease‐specific DSS in men with Gleason score ≤6 prostate cancer at radical prostatectomy RP ). Patients Methods We included 1101 consecutive patients operated between March 1985 to July 2013 a single institution. The outcome variables were . postoperative was estimated by Kaplan–Meier method. Results distribution of study population (1101 patients) (449, 41%), 3 + 4 = 7 (436, 40%), (99, 9%) 8–10 (117, 11%). median (interquartile...
// René Böttcher 1, 3 , A. Marije Hoogland 2 Natasja Dits 1 Esther I. Verhoef Charlotte Kweldam Piotr Waranecki Chris H. Bangma Geert J.L.H. van Leenders Guido Jenster Dept. of Urology, Erasmus MC, Rotterdam, The Netherlands Pathology, Bioinformatics, Technical University Applied Sciences Wildau, Germany Correspondence to: Jenster, e-mail: g.jenster@erasmusmc.nl Keywords: Long non-coding RNA, prostate cancer, in situ hybridization, exon array, biomarkers Received: August 22, 2014 Accepted:...
Intraductal carcinoma of the prostate (IDC-P) has been recently recognized by World Health Organization classification prostatic tumors as a distinct entity, most often occurring concurrently with invasive adenocarcinoma (PCa). Whether documented admixed PCa or in its rare pure form, numerous studies associate this entity clinical aggressiveness. Despite increasing experience and requirement IDC-P documentation protocols for synoptic reporting, specifics potential contribution to assessment...