A5008500496- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Radiopharmaceutical Chemistry and Applications
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
- Reconstructive Surgery and Microvascular Techniques
- Hormonal and reproductive studies
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ureteral procedures and complications
- Ethics and Legal Issues in Pediatric Healthcare
- 3D Printing in Biomedical Research
- PARP inhibition in cancer therapy
- Lung Cancer Research Studies
- Hemophilia Treatment and Research
- Tissue Engineering and Regenerative Medicine
Sint Franciscus Gasthuis
2022-2024
Erasmus MC
2012-2023
Erasmus MC Cancer Institute
2019-2023
Maasstad Ziekenhuis
2020-2023
The Prostate Centre
2022
Erasmus University Rotterdam
2008-2021
Rotterdam University of Applied Sciences
2011-2017
University Hospital and Clinics
2017
University Medical Center
2017
In-Q-Tel
2000
Nerve-sparing (NS) radical prostatectomy (RP) results in better functional outcomes. Intraoperative neurovascular structure-adjacent frozen section examination (NeuroSAFE) significantly increases the frequency of NS surgery. The effect NeuroSAFE on postoperative erectile function (EF) and continence is not yet clear.
European Association of Urology guidelines recommend a risk-adjusted biopsy strategy for early detection prostate cancer in biopsy-naïve men. It remains unclear which is most effective. Therefore, we evaluated two risk assessment pathways commonly used clinical practice.To compare the diagnostic performance risk-based ultrasound (US)-directed pathway (Rotterdam Prostate Cancer Risk Calculator [RPCRC] #3; US volume assessment) and magnetic resonance imaging (MRI)-directed pathway.This was...
FGFR3 mutations occur in 70% of nonmuscle invasive bladder tumors. Although urine based mutation analysis can detect recurrence, its sensitivity may be limited if samples have few or no tumor cells. We determined whether test depends on size and the time point collection, how to increase sensitivity.A total 440 from 18 patients with a suspicious lesion at cystoscopy were collected during 6 days before surgery. Eight (300 samples) had an mutant tumor, including 4 each greater than 3 less 1.5...
The gastrin-releasing peptide receptor (GRPr) is overexpressed in prostate cancer (PCa) cells, making it an excellent tool for targeted imaging. <sup>68</sup>Ga-labeled GRPr antagonist SB3 has shown results preclinical and clinical studies was selected further investigation. aims of this phase I study were to investigate <sup>68</sup>Ga-SB3 PET/CT imaging primary PCa tumors assess safety. More included investigation biodistribution dosimetry a comparison with pathology expression....
Study Type – Diagnostic (cohort) Level of Evidence 2b What's known on the subject? and What does study add? So far, few publications have shown that a prediction model influences behaviour both physicians patients. To our knowledge, it was unknown whether urologists patients are compliant with recommendations prostate cancer risk calculator their reasons for non‐compliance. Recommendations European Randomized Screening Prostate Cancer (ERSPC RC) about need biopsy were followed in most In...
Aims Radical prostatectomy for prostate cancer is frequently complicated by urinary incontinence and erectile dysfunction. Nerve‐sparing surgery reduces the risk of postoperative complications can be optimised use intraoperative frozen sections adjacent neurovascular structure (NeuroSAFE). The aims this study were to evaluate pathological outcomes NeuroSAFE technique develop a comprehensive algorithm clinical decision‐making. Methods results Between September 2018 May 2019, 491 procedures...
Study Type - Prognosis (cohort series). Level of Evidence 2a. What's known on the subject? and What does study add? The present is one first to investigate urologists' patients' compliance with recommendations based a risk calculator that calculates probability indolent prostate cancer. A threshold was set for recommendation active surveillance vs treatment. Active cancer were followed by most patients, but 30% treatment chose instead. This indicates may be too high urologists patients.• To...
Radical prostatectomy (RP) for prostate cancer is frequently complicated by erectile dysfunction and urinary incontinence. However, sparing of the nerve bundles adjacent to posterolateral sides reduces number complications at risk positive surgical margins. Preoperative selection men eligible safe, nerve-sparing surgery therefore needed. Our aim was identify pathological factors associated with margins in undergoing bilateral RP.Prostate patients RP standardised intra-operative margin...
To identify parameters to predict upgrading in biopsy Grade Group (GG) 2 prostate cancer patients without cribriform and intraductal carcinoma (CR/IDC) on biopsy.Preoperative biopsies from 657 men undergoing radical prostatectomy (RP) for were reviewed GG, presence of CR/IDC, percentage Gleason pattern 4, tumor length. In with GG2 CR/IDC (n = 196), clinicopathologic features compared between those GG1 or RP (GG ≤ 2-) any GG > ≥ 2+). Logistic regression analysis was used the cohort.In total...
On the basis of previous analyses incidence urinary incontinence (UI) after radical prostatectomy (RP), hospital RP volume threshold in Netherlands was gradually increased from 20 per year 2017, to 50 2018 and 100 2019 onwards.To evaluate impact volumes on risk UI (RP-UI).Patients who underwent during 2016-2020 were identified claims database largest health insurance company Netherlands. Incontinence defined as an claim for ≥1 pads/d.The relationship between (HV) RP-UI assessed via...