A5060005820- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Statistical Methods in Clinical Trials
- Cancer, Lipids, and Metabolism
- AI in cancer detection
- MRI in cancer diagnosis
- Urologic and reproductive health conditions
- Artificial Intelligence in Healthcare and Education
- Advanced Radiotherapy Techniques
- Global Cancer Incidence and Screening
- Medical Imaging and Analysis
- Cardiovascular Health and Disease Prevention
- Delphi Technique in Research
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Cell Adhesion Molecules Research
- Cancer Cells and Metastasis
- Proteoglycans and glycosaminoglycans research
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Hemodynamic Monitoring and Therapy
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Galectins and Cancer Biology
Erasmus MC Cancer Institute
2018-2024
Erasmus MC
2019-2023
Erasmus University Rotterdam
2019-2020
Radboud University Nijmegen
2019
Radboud University Medical Center
2019
Radboud Institute for Molecular Life Sciences
2019
Elisabeth-TweeSteden Ziekenhuis
2016-2019
Artificial intelligence (AI) is rapidly fuelling a fundamental transformation in the practice of pathology. However, clinical integration remains challenging, with no AI algorithms to date routine adoption within typical anatomic pathology (AP) laboratories. This survey gathered current expert perspectives and expectations regarding role AP from those first-hand computational experience.Perspectives were solicited using Delphi method 24 subject matter experts between December 2020 February...
Invasive cribriform and intraductal carcinoma are associated with adverse clinical outcome in patients Gleason score 7 prostate cancer. It is yet unclear whether invasive of the both have independent prognostic value, or field size has impact on disease outcome. Our objective was to determine cancer histological subtypes radical prostatectomies. We reviewed 420 prostatectomy specimens ISUP grade 2 cancer, assessed percentages 4 tertiary 5, performed immunohistochemistry for basal cells...
The Gleason score is an important parameter for clinical outcome in prostate cancer patients. 8 a heterogeneous disease including 3 + 5, 4 4, and 5 tumors, encompasses broad range of tumor growth patterns. Our objective was to characterize individual patterns identify prognostic parameters We reviewed 1064 radical prostatectomy specimens, recorded as well presence intraductal carcinoma, evaluated biochemical recurrence- metastasis-free survival. identified 140 (13%) patients, whom 76 (54%)...
To investigate the expression of MMP-14 and CD44 as well epithelial-to-mesenchymal transition(EMT)-like changes in ovarian cancer to determine correlations with clinical outcome.In 97 patients cancer, determined by immunohistochemistry was investigated relation EMT-like changes. this, immunohistochemical staining E-cadherin vimentin performed.Patients both their tumors had a poor prognosis despite complete debulking. Serous histology advanced-stage (FIGO IIB-IV) correlated (rho .286, p <...
Aims Invasive cribriform and/or intraductal carcinoma have been identified as independent adverse parameters for prostate cancer outcome. Little is known on biopsy undersampling of architecture. Our aim was to determine the extent architecture and find predictive factors identifying false cribriform‐negative cases. Methods results We reviewed 186 matched biopsies radical prostatectomy specimens. Of 97 grade group 2 (Gleason score 3 + 4 = 7) patients, 22 (23%) had true (TN), 39 (40%)...
Abstract The Grade group is an important parameter for clinical decision-making in prostate cancer. Recently, percent Gleason pattern 4 and presence of invasive cribriform and/or intraductal carcinoma (CR/IDC) have been recognized their independent predictive value cancer outcome. There sparse data on the inter-observer agreement these pathologic features practice. Our objectives were to investigate variability CR/IDC relate individual tumour scores cohort included 80 consecutive radical...
Postoperative biochemical recurrence occurs in up to 40% of prostate carcinoma patients treated with radical prostatectomy. Primary tumor grade and cribriform architecture are important parameters for clinical outcome; however, their relevance at positive surgical margins has not been completely elucidated yet. We reviewed 835 prostatectomy specimens recorded pT-stage, margin status, Grade Group, the primary margins. Clinicopathologic recurrence-free survival (BCRFS) were used as endpoints....
Invasive cribriform and intraductal carcinoma are associated with aggressive disease in Grade Group 2 (GG2) prostate cancer patients. However, the characteristics clinical outcome of patients GG2 without architecture (GG2-) as compared those 1 (GG1) unknown. The aim this study was to investigate pathological GG1 GG2- radical prostatectomy specimens.We reviewed 835 specimens for Group, pT stage, surgical margin status, presence architecture. Biochemical recurrence-free survival metastasis...
Cribriform growth patterns in prostate carcinoma are associated with poor prognosis. We aimed to introduce a deep learning method detect such automatically. To do so, convolutional neural network was trained cribriform on 128 needle biopsies. Ensemble taking into account other tumor during training used cope heterogeneous and limited tissue occurrences. ROC FROC analyses were applied assess performance regarding detection of biopsies harboring pattern. The analysis yielded mean area under...
Intraductal carcinoma (IDC) is an adverse histopathological parameter for prostate cancer outcome, but not incorporated in current tumour grading. To account its dismal prognosis and to omit basal cell immunohistochemistry, it has been proposed grade IDC on the basis of underlying architectural pattern. The aim this study was determine impact assignment biopsy radical prostatectomy
Individual growth patterns and cribriform architecture are increasingly considered in risk stratification clinical decision-making men with prostate cancer. Our objective was to establish the prognostic value of individual Gleason 5 a radical prostatectomy (RP) cohort. We reviewed 1064 RPs recorded Grade Group (GG), pT-stage, surgical margin status, 4 as well intraductal carcinoma. The endpoints were biochemical recurrence post-operative distant metastasis. pattern present 339 (31.9%) RPs,...
Gleason pattern 4 (GP4) percentage, invasive cribriform and/or intraductal carcinoma (IC/IDC) and the presence of tertiary 5 (TP5) in radical prostatectomy (RP) specimens all aid risk stratification Grade Group (GG) 2 prostate cancer patients. However, it is unclear to what extent these pathological features are mutually related their individual values if they investigated simultaneously. The aims this study were: (i) determine mutual relationships GP4 IC/IDC TP5 GG2 RP specimens; (ii)...
PurposeCribriform pattern has recently been recognized as an important independent risk factor for prostate cancer (PCa) outcome. This study aimed to identify the association of quantifiable magnetic resonance imaging (MRI) parameters with any and large cribriform at radical prostatectomy (RP) specimens.MethodsPreoperative MRI's from 188 men undergoing RP between 2010 2018 were retrospectively acquired. specimens patients revised Gleason score (GS), presence pattern. MRI such visibility,...
Glomeruloid architecture is the least common Gleason 4 growth pattern in prostate adenocarcinoma. Its clinicopathological features and relation with cribriform architecture, which has been recognized as an adverse feature, remains to be established. Our objective was investigate of glomeruloid radical prostatectomies. We reviewed 1064 prostatectomy specimens recorded Grade Group, pT-stage, margin status, percentages, patterns. Simple complex glomerulations were distinguished by gland size...
Percentage Gleason pattern 4, invasive cribriform and/or intraductal carcinoma (IC/IDC) and minor 5 are recognized as independent parameters for prostate cancer outcome, but not incorporated in current grade groups (GGs). Two proof-of-principle studies have proposed alternative grading schemes based on percentage 4/5 (integrated quantitative score; IQ-Gleason) IC/IDC presence (cribriform grade; cGrade). Our objective was to compare the performance of GG, IQ-Gleason cGrade predicting...
The risk on biochemical recurrence (BCR) after radical prostatectomy (RP) is usually estimated using PSA and pathological stage grading including the presence of positive surgical margins (PSM). Objective was to investigate whether cribriform growth in primary tumor, Grade Group (GG) at PSM, length PSM have added value prognostication. We analyzed data 835 patients initially treated with RP between 2000 2017. Cox regression models were developed compare baseline model (PSA, pT-stage,...
To investigate the surgical margin status in patients with prostate cancer who underwent robot-assisted radical prostatectomy (RARP) intraoperative neurovascular structure-adjacent frozen-section analysis (NeuroSAFE) and evaluate differences compared to without NeuroSAFE.
Lymphogenic and hematogenic metastases are uncommon in ovarian cancer, especially at presentation. We hypothesized that MMP-14 MMP-2, CD44, highly sulfated chondroitin sulfate (CS-E) may be overexpressed tumors with these metastatic patterns. These molecules all present the tumor microenvironment, wherein they interact. In an cancer cohort of 44 patients lymph nodes, spleen, and/or liver, presence MMP-14, CS-E both primary was determined immunohistochemistry related to clinical...
ABSTRACT Background Artificial intelligence (AI) is rapidly fueling a fundamental transformation in the practice of pathology. However, AI’s clinical integration remains challenging, with no AI algorithms to date enjoying routine adoption within typical anatomic pathology (AP) laboratories. This survey gathered current expert perspectives and expectations regarding role AP from those first-hand computational experience. Methods Perspectives were solicited using Delphi method 24 subject...