A5100347217- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
- Retinal Development and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Dental Protein Studies
- Sperm and Testicular Function
- RNA modifications and cancer
Yidu Central Hospital of Weifang
2023
North Sichuan Medical University
2022
Zhejiang University
2022
Guangdong Medical College
2021
Xiangya Hospital Central South University
2021
Baogang Group (China)
2021
Central South University
2021
Jilin Province Tumor Hospital
2021
First Affiliated Hospital of Zhengzhou University
2020
Case Western Reserve University
2007
Allergic rhinitis (AR) is a common allergic disease which characterized by the promotion of Th2 differentiation CD4+ T cells. However, mechanisms underlying remain unclear. Non-coding RNAs play critical role in differentiation, whereas few studies have revealed interactions among long non-coding RNAs, circular and microRNAs. In this study, differential expressions several circRNAs lncRNAs were compared nasal mucosa samples AR patients mice with experimentally induced as to healthy controls....
Circular RNAs (circRNAs) are a recently discovered noncoding RNA isoform capable of regulating neurological disease incidence. The present study was designed to characterize the circRNA expression profiles in large-artery atherosclerosis (LAA)-type acute ischemic stroke patients and detect biomarkers suitable for LAA-stroke detection. Using RNA-seq-based approach, we characterized five four controls. We confirmed differential target circRNAs through quantitative real-time polymerase chain...
Clear cell renal carcinoma (ccRCC) is a primary kidney cancer with high aggressive phenotype and extremely poor prognosis.Accumulating evidence suggests that circular RNAs (circRNAs) play pivotal roles in the occurrence development of various human cancers.However, expression, clinical significance regulatory role circRNAs ccRCC remain largely unclear.Here we report circDVL1 to be reduced serums tissues from patients, negatively correlate malignant features.Overexpression inhibits...
Ulcerative colitis (UC) is a chronic with unknown etiology. Circular RNA (circRNA) has shown regulatory effect in many diseases, but the role of circRNA UC barely known. This study uncovers function and mechanism HECTD1 (circHECTD1) UC.Colonic mucosal tissues 60 patients active 30 healthy controls were collected for H&E staining. Lipopolysaccharide (LPS) dextran sulfate sodium (DSS) used to induce inflammation Caco-2 cells C57BL/6 mice where modification circHECTD1, miR-182-5p and/or human...
Cerebral ischemia/reperfusion (CI/R) injury results in serious brain tissue damage, thereby leading to long-term disability and mortality. It has been reported that dexmedetomidine (DEX) exerted neuroprotective effects CI/R injury. Herein, we intended investigate whether how circular RNA (circRNA) cerebellar degeneration-related protein 1 antisense (circ-CDR1as) was involved the DEX-mediated protection on hippocampal neurons. In our work, mouse neuronal cells (HT-22) were used construct a...
Background: Oral squamous cell carcinoma (OSCC) has become a widely concerned social problem. Circular RNA spermatogenesis-associated protein 6 (circSPATA6) exhibited low expression in OSCC tissues, yet the regulatory mechanism of circSPATA6 remains vague. Methods: Levels circSPATA6, linear SPATA6, microRNA-182 (miR-182), and tumor necrosis factor receptor-associated (TRAF6) were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Migration, invasion, cycle arrest,...
<p>Differentially expressed microRNAs in Pan-Gyn cohort EA vs AA</p>
Rac2 is a Rho-family small GTPase thought to be expressed only by hematopoietic cells. It participates in activating signaling cascades regulate cellular functions. Studies chimeric wild type mice with Rac2−/− stem cells show that deficiency recipient lungs results increased permeability. These data suggest may non-hematopoietic Our studies determined if pulmonary endothelial Lungs were enzymatically digested isolate single lung Three cell populations isolated using anti-rat IgG magnetic...
Abstract Purpose Exploring the role of activity-regulated cytoskeleton-associated (Arc) in visual cortex development, and studying its expression changes amblyopia kittens. Methods Fifteen 3-week-old kittens were randomly selected from deprivation group control group, raised natural environment. Black opaque covering cloth was used to cover right eye deprived Pattern evoked potentials (PVEP) detected at 3rd, 4th, 6th 8th weeks age, 5 each euthanized after detection. The Arc both mRNA protein...