A5100785510- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Vibrio bacteria research studies
- Influenza Virus Research Studies
- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Genomics and Phylogenetic Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Research and Treatments
- Protist diversity and phylogeny
- Parasite Biology and Host Interactions
- Invertebrate Immune Response Mechanisms
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- Myxozoan Parasites in Aquatic Species
- Complement system in diseases
- RNA modifications and cancer
- Viral Infections and Vectors
- Animal Genetics and Reproduction
- COVID-19 epidemiological studies
- Pharmacological Effects of Natural Compounds
- Cleft Lip and Palate Research
- Cancer-related Molecular Pathways
Fujian Academy of Agricultural Sciences
2016-2025
Shenzhen University
2023-2024
Animal Science Research Institute
2021-2023
Shenzhen Sixth People's Hospital
2023
Fudan University
2021-2022
Ningbo University
2020-2022
Central South University
2016-2021
Nanjing Maternity and Child Health Care Hospital
2009-2021
Xiangya Hospital Central South University
2021
Nanjing Medical University
2021
Abstract Background The contributive role of the microbiome in tumor progression has been reported multiple studies, such as Fusobacterium nucleatum ( F. ) breast cancer (BC). This study aimed to explore -derived small extracellular vesicles (Fn-EVs) BC and preliminarily uncover mechanism. Methods Ten normal 20 cancerous tissues were harvested investigate gDNA expression its relation with clinical characteristics patients. After isolating Fn-EVs by ultracentrifugation from (ATCC 25,586),...
Introduction The prevalence of viral diseases has posed significant challenges to the sustainable development large yellow croaker ( Larimichthys crocea ) aquaculture, with megalocytivirus being one primary pathogens affecting this species. There have been two proteomic and genomic studies regarding members genus Megalocytivirus : spotted knifejaw iridovirus (SKIV) infectious spleen kidney necrosis virus (ISKNV). However, both were conducted more than 10 years ago. To further investigate...
Triptolide (TP), an active ingredient of Tripterygium wilfordii Hook f., possesses a wide range biological activities. Oxidative stress likely plays role in TP‐induced hepatotoxicity. Isoliquiritigenin (ISL) and glycyrrhetinic acid (GA) are potent hepatoprotection agents. The aim the present study was to investigate whether Nrf2 pathway is associated with protective effects ISL GA against oxidative or not. HepG2 cells were treated TP (50 nM) for 24 h after pretreatment (5, 10, 20 μ M) 12 h,...
Objective: To estimate the health impact and economic burden of seasonal influenza in mainland China. Methods: From systematic literature reviews, we collected influenza-associated excess influenza-like-illness (ILI) outpatient consultation rates, hospitalization rates severe acute respiratory infections (SARI) mortality, 2006-2017. Using these data, as well demographic data (2019), number ILI consultations, SARI hospitalizations deaths were estimated. Then using per capita consultations...
Lipolytic enzymes are essential biocatalysts in food processing as well pharmaceutical and pesticide industries, catalyzing the cleavage of ester bonds a variety acyl chain substrates. Here, we report crystal structure an esterase from deep-sea hydrothermal vent East Pacific Rise (EprEst). The X-ray EprEst complex with ligand, acetate, has been determined at 2.03 Å resolution. reveals unique spatial arrangement orientation helix cap domain α/β hydrolase domain, which form substrate pocket...
Ulcerative colitis (UC) is a chronic with unknown etiology. Circular RNA (circRNA) has shown regulatory effect in many diseases, but the role of circRNA UC barely known. This study uncovers function and mechanism HECTD1 (circHECTD1) UC.Colonic mucosal tissues 60 patients active 30 healthy controls were collected for H&E staining. Lipopolysaccharide (LPS) dextran sulfate sodium (DSS) used to induce inflammation Caco-2 cells C57BL/6 mice where modification circHECTD1, miR-182-5p and/or human...
To investigate the potential role of nuclear factor erythroid 2-related 2 (Nrf2) in licorice ethanol extract (LEE) against triptolide- (TP-) induced hepatotoxicity, HepG2 cells were exposed to LEE (30, 60, and 90 mg·L-1) for 12 h then treated with TP (50 nM) 24 h. Besides, an acute liver injury model was established ICR mice by a single dose (1.0 mg·kg-1, i.p.). Relevant oxidant antioxidant mediators analyzed. led obvious oxidative stress as evidenced increasing levels ROS decreasing GSH...
The development of effective vaccines and delivery systems in aquaculture is a long-term challenge for controlling emerging reemerging infections. Cost-efficient advanced nanoparticle are tremendous applicability prevention infectious diseases fish. In this study, dihydrolipoamide dehydrogenase (DLDH) antigens Vibrio alginolyticus were loaded into mesoporous silica nanoparticles (MSN) to compose the vaccine system. Hydroxypropyl methylcellulose phthalate (HP55) was coated provide protection...
Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts action of complement at critical stages cascade reaction. The cooperative effect DAF MCP on survival human cervical cancer (ME180) has not been demonstrated. In this study we applied, for first time, short hairpin RNA (shRNA) to knock down expression with aim exploiting more effectively tumor damage. Meanwhile, investigated...
A new cell line derived from the kidney of European eel, Anguilla anguilla, has been established and characterized. This line, designated as EK (eel kidney), maintained in Leibovitz's L-15 supplemented with 10% fetal bovine serum for over 24 months, subcultured more than 60 times. consists predominantly fibroblast-like cells, can grow at 15-37°C under an optimum temperature 26°C. The origin this was confirmed by polymerase chain reaction (PCR) amplification 18s recombinant (r)RNA sequencing....
The ciliated protozoan Cryptocaryon irritans infects a wide range of marine fish and causes the highly lethal white spot disease. This parasite possesses three morphologically physiologically distinct life stages: an infectious theront, parasitic trophont, asexually reproductive tomont. In past few years, several attempts have been made to help elucidate how C. transforms from one stage another using transcriptomic or proteomic approaches. However, there has no research studying changes in...
In the present study, a new hepatic tissue-origin cell line from European eel Anguilla anguilla has been developed and characterized. This designated EL maintained in Leibovitz L-15 supplemented with 10% fetal bovine serum over 72 months, subcultured more than 90 times. The consisted predominantly of fibroblast-like cells, which could survive 100 days vitro, grow at 15-32°C. optimum temperature for growth was 27°C. chromosome analysis revealed modal diploid karyotype 2n = 38. origin this...