Patricia Taik
A5039819375- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Protist diversity and phylogeny
- Renal cell carcinoma treatment
- Soft tissue tumor case studies
- Aquaculture disease management and microbiota
- Urinary and Genital Oncology Studies
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Genomics and Phylogenetic Studies
- Chronic Lymphocytic Leukemia Research
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
Sema4 (United States)
2019-2023
Icahn School of Medicine at Mount Sinai
2019-2021
Hamilton College
2017
We previously reported a characterisation of the hepatocellular carcinoma (HCC) immune contexture and described an immune-specific class. now aim to further delineate immunogenomic classification HCC incorporate features that explain responses/resistance immunotherapy.
A novel Drosophila -based approach resulted in a significant response by patient with KRAS-mutant colorectal cancer.
Abstract Context Pituitary corticotroph adenomas are rare tumors that can be associated with excess adrenocorticotropin (ACTH) and adrenal cortisol production, resulting in the clinically debilitating endocrine condition Cushing disease. A subset of behave aggressively, genomic drivers behind development these largely unknown. Objective To investigate at risk for aggressive behavior. Design Whole-exome sequencing patient-matched tumor normal deoxyribonucleic acid (DNA) from a patient cohort...
Adenoid cystic carcinoma (ACC) is a rare cancer type that originates in the salivary glands. Tumors commonly invade along nerve tracks head and neck, making surgery challenging. Follow-up treatments for recurrence or metastasis including chemotherapy targeted therapies have shown limited efficacy, emphasizing need new therapies. Here, we report Drosophila-based therapeutic approach patient with advanced ACC disease. A patient-specific Drosophila transgenic line was developed to model five...
Abstract Purpose: Mongolia has the world's highest incidence of hepatocellular carcinoma (HCC), with ∼100 cases/100,000 inhabitants, although reasons for this have not been thoroughly delineated. Experimental Design: We performed a molecular characterization Mongolian (n = 192) compared Western 187) HCCs by RNA sequencing and whole-exome to unveil distinct genomic transcriptomic features associated environmental factors in population. Results: patients were younger, higher female prevalence,...
Abstract Ossifying fibromas are very rare tumors that sometimes seen as part of the hyperparathyroidism-jaw tumor syndrome (HPT-JT), which is caused by inactivating mutations HRPT2/CDC73 suppressor gene. CDC73 have been identified in a subset sporadic cases but aberrant expression encoded protein, parafibromin, has not demonstrated ossifying fibroma. We sought to determine if loss parafibromin regularly contributes development sporadic, nonsyndromic examined series 9 fibromas, including...
Abstract Background Treatment options have been historically limited for cisplatin-ineligible patients with advanced urothelial carcinoma (UC). Given the need alternatives to platinum-based chemotherapy, including non-chemotherapy regimens both impaired renal function and borderline functional status, in 2010 (prior immune checkpoint blockade era metastatic UC), we initiated a phase II trial test activity of everolimus or plus paclitaxel setting. Methods This was an open-label conducted...
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Data from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Data from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents
Supplementary Figure from Hepatocellular Carcinoma in Mongolia Delineates Unique Molecular Traits and a Mutational Signature Associated with Environmental Agents