A5091475131- Aquaculture disease management and microbiota
- interferon and immune responses
- Parasite Biology and Host Interactions
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Myxozoan Parasites in Aquatic Species
- Animal Virus Infections Studies
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Protist diversity and phylogeny
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- Parasitic Infections and Diagnostics
- Microbial infections and disease research
- Coral and Marine Ecosystems Studies
- Marine Ecology and Invasive Species
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Fish biology, ecology, and behavior
- Virus-based gene therapy research
- Melanoma and MAPK Pathways
- Aquatic Invertebrate Ecology and Behavior
- Vibrio bacteria research studies
- RNA Research and Splicing
- Aquatic Ecosystems and Biodiversity
Musashino University
2017-2024
Hiroshima University
2010-2022
The University of Tokyo
2005-2021
Pukyong National University
2006-2010
Abstract The signal transducer and activator of transcription 1 ( STAT 1), a pivotal factor in Janus kinase JAK )– signaling, regulates the expression wide range immune‐related genes, including interferon (IFN) regulatory IRF 1). In this study, we found that could induce phosphorylation turn activation. When was transiently expressed HEK 293 cells, phosphorylated at Y701, dimerized bound to an oligonucleotide containing gamma‐activated sequence GAS ) derived from promoter. also induced...
Abstract LPS interacts with TLR4, which play important roles in host-against-pathogen immune responses, by binding to MD-2 and inducing an inflammatory response. In this study, our knowledge, we found a novel function of lipoteichoic acid (LTA), TLR2 ligand, that involves suppression TLR4-mediated signaling independently under serum-free conditions. LTA inhibited NF-κB activation induced or synthetic lipid A noncompetitive manner human embryonic kidney 293 cells expressing CD14, MD-2. This...
A dual vector expressing the ghost-inducing PhiX174 lysis E gene and bacterial DNA degrading staphylococcal nuclease (SNA) was constructed to solve problem of remnant antibiotic resistance genes genomic with intact pathogenic islands in final product Edwardsiella tarda ghosts (ETG). The SNA (devoid secretion signal sequence B amino terminus sequence), fused 26 acid N-terminal lambda phage Cro gene, showed successful degradation nucleic acids. Furthermore, activity E. enhanced by codon...
Abstract Background Betanodaviruses, members of the family Nodaviridae , have bipartite, positive-sense RNA genomes and are causal agents viral nervous necrosis in many marine fish species. Recently, viruses were shown to infect a few freshwater species including model medaka ( Oryzias latipes ). Although virological study using cultured cells would provide lot insight into virus-fish interactions molecular aspects, no such yet been tested for virus susceptibility. Results We ten cell lines...
Cryptocaryon irritans has clear daily rhythms in protomont detachment from fish and theront excystment tomonts. While the seem to be regulated by photoperiods, it not been confirmed. We investigated whether of parasite would controlled giving different photoperiods 12 h light dark (06:00–18:00 L 18:00–06:00 D; 15:00–03:00 03:00–15:00 D) infected Protomont theronts mostly occurred last 3 period 6 before end period, respectively, indicating that are photoperiods.
Cryptocaryon irritans Brown 1951 is a parasitic ciliate of marine teleosts, which causes cryptocaryoniasis ('white spot disease'), and was first described in the Aquarium Tokyo Imperial University Japan (Sikama, 1937).The parasite invades epithelial layer skin gills teleosts disturbs osmotic control respiratory activity its host, often causing mass mortalities heavily infected fish (Colorni Burgess, 1997).This major threat to aquaculture tropical subtropical waters 1997).The life cycle C....